clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Braden B | The best and worst treatments for Helicobacter pylori. | 2015 | BMJ | pmid:26290321 |
Li BZ et al. | Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis. | 2015 | BMJ | pmid:26290044 |
Haider RB et al. | A randomized-controlled study to compare the efficacy of sequential therapy with standard triple therapy for Helicobacter pylori eradication in an Irish population. | 2015 | Eur J Gastroenterol Hepatol | pmid:26287955 |
Shallom SJ et al. | New Real-Time PCR Assays for Detection of Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Group. | 2015 | J. Clin. Microbiol. | pmid:26269619 |
Zagari RM et al. | Guidelines for the management of Helicobacter pylori infection in Italy: The III Working Group Consensus Report 2015. | 2015 | Dig Liver Dis | pmid:26253555 |
Sprague J et al. | Cutaneous infection with Mycobacterium kansasii in a patient with myelodysplastic syndrome and Sweet syndrome. | 2015 | Cutis | pmid:26244358 |
Sharara AI et al. | Letter: clarithromycin dose for H. pylori therapy remains unresolved--authors' reply. | 2015 | Aliment. Pharmacol. Ther. | pmid:26238584 |
Matsumoto T et al. | Mycobacterium fortuitum thoracic empyema: A case report and review of the literature. | 2015 | J. Infect. Chemother. | pmid:26139179 |
Losurdo G et al. | Sequential vs. prolonged 14-day triple therapy for Helicobacter pylori eradication: the meta-analysis may be influenced by 'geographical weighting'. | 2015 | Int. J. Clin. Pract. | pmid:26138290 |
Zhang T | Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for atorvastatin and its metabolites. | 2015 | Eur J Pharm Sci | pmid:26116278 |
Fraser LA et al. | Calcium channel blocker-clarithromycin drug interaction did not increase the risk of nonvertebral fracture: a population-based study. | 2015 | Ann Pharmacother | pmid:25429094 |
Lee SJ et al. | Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice. | 2015 | PLoS ONE | pmid:26114656 |
Dimer F et al. | Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections. | 2015 | Pharm. Res. | pmid:26113237 |
Kasai A et al. | Prevalence and molecular analysis of macrolide-resistant Moraxella catarrhalis clinical isolates in Japan, following emergence of the highly macrolide-resistant strain NSH1 in 2011. | 2015 | J. Med. Microbiol. | pmid:25934551 |
Chou HW et al. | Risks of cardiac arrhythmia and mortality among patients using new-generation macrolides, fluoroquinolones, and β-lactam/β-lactamase inhibitors: a Taiwanese nationwide study. | 2015 | Clin. Infect. Dis. | pmid:25409476 |
Mahmoudi A et al. | Microbiological assay for the analysis of certain macrolides in pharmaceutical dosage forms. | 2015 | Int J Pharm | pmid:26112961 |
Flores-Gonzalez JC et al. | [Etiology, clinical presentation and outcome of severe viral acute childhood encephalitis (ECOVE study)]. | 2015 | Rev Neurol | pmid:26108903 |
Hill FJ et al. | From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions. | 2015 | BMJ Case Rep | pmid:26106178 |
Tojima I et al. | Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium. | 2015 | Auris Nasus Larynx | pmid:25769240 |
Nonaka L et al. | Novel macrolide-resistance genes, mef(C) and mph(G), carried by plasmids from Vibrio and Photobacterium isolated from sediment and seawater of a coastal aquaculture site. | 2015 | Lett. Appl. Microbiol. | pmid:25765542 |
Tsunemine H et al. | [Successful treatment of relapsed and refractory multiple myeloma by using clarithromycin-lenalidomide, low-dose dexamethasone(BiRd), and melphalan-prednisolone(MP)]. | 2015 | Gan To Kagaku Ryoho | pmid:25981655 |
Ribaldone DG et al. | Efficacy of amoxycillin and clarithromycin-based triple therapy for Helicobacter pylori eradication: a 10-year trend in Turin, Italy. | 2015 | Panminerva Med | pmid:25971330 |
Thellin O et al. | In vitro approach to study the synergistic effects of tobramycin and clarithromycin against Pseudomonas aeruginosa biofilms using prokaryotic or eukaryotic culture media. | 2015 | Int. J. Antimicrob. Agents | pmid:25963337 |
Hwang JJ et al. | Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease. | 2015 | World J. Gastroenterol. | pmid:25945019 |
Liou JM et al. | The Primary Resistance of Helicobacter pylori in Taiwan after the National Policy to Restrict Antibiotic Consumption and Its Relation to Virulence Factors-A Nationwide Study. | 2015 | PLoS ONE | pmid:25942450 |
Ferreri AJ et al. | High-dose clarithromycin is an active monotherapy for patients with relapsed/refractory extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT): the HD-K phase II trial. | 2015 | Ann. Oncol. | pmid:25935794 |
Ito A et al. | Increase in SCCmec type IV strains affects trends in antibiograms of meticillin-resistant Staphylococcus aureus at a tertiary-care hospital. | 2015 | J. Med. Microbiol. | pmid:25934550 |
Andrianov M et al. | A 15-year-old boy with abdominal pain, growth retardation, and anemia secondary to Helicobacter pylori-associated peptic ulcer. | 2015 | Pediatr Ann | pmid:25806733 |
Zhao C et al. | [Resistance surveillance of major pathogens for adult community-acquired respiratory tract infections in China: a multicenter study 2012]. | 2015 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:25791651 |
Molina-Infante J et al. | Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: the OPTRICON study. | 2015 | Aliment. Pharmacol. Ther. | pmid:25776067 |
Takahashi C et al. | Observation of antibacterial effect of biodegradable polymeric nanoparticles on Staphylococcus epidermidis biofilm using FE-SEM with an ionic liquid. | 2015 | Microscopy (Oxf) | pmid:25757698 |
Metanat HA et al. | Comparison Between 10- and 14-Day Hybrid Regimens for Helicobacter pylori Eradication: A Randomized Clinical Trial. | 2015 | Helicobacter | pmid:25752357 |
Essilfie AT et al. | Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma. | 2015 | Thorax | pmid:25746630 |
Bouilhat N et al. | High-level primary clarithromycin resistance of Helicobacter pylori in Morocco: a prospective multicenter molecular study. | 2015 | Helicobacter | pmid:25735573 |
Guzman Vinasco L et al. | Acute suppurative parotitis caused by Streptococcus pneumoniae in an HIV-infected man. | 2015 | BMJ Case Rep | pmid:25733094 |
Mitsui Y et al. | Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication. | 2015 | Clin J Gastroenterol | pmid:25733031 |
Ben Chaabane N and Al-Adhba HS | Ciprofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: A randomized trial. | 2015 | Indian J Gastroenterol | pmid:25721770 |
Zhou Z et al. | Macrolide-resistant Mycoplasma pneumoniae in adults in Zhejiang, China. | 2015 | Antimicrob. Agents Chemother. | pmid:25451048 |
Winkel P et al. | Clarithromycin for stable coronary heart disease increases all-cause and cardiovascular mortality and cerebrovascular morbidity over 10years in the CLARICOR randomised, blinded clinical trial. | 2015 | Int. J. Cardiol. | pmid:25602299 |
Trespalacios AA et al. | Improved allele-specific PCR assays for detection of clarithromycin and fluoroquinolone resistant of Helicobacter pylori in gastric biopsies: identification of N87I mutation in GyrA. | 2015 | Diagn. Microbiol. Infect. Dis. | pmid:25600075 |
Yoshida S et al. | Investigation of the population structure of Mycobacterium abscessus complex strains using 17-locus variable number tandem repeat typing and the further distinction of Mycobacterium massiliense hsp65 genotypes. | 2015 | J. Med. Microbiol. | pmid:25596119 |
Ontsira Ngoyi EN et al. | Molecular Detection of Helicobacter pylori and its Antimicrobial Resistance in Brazzaville, Congo. | 2015 | Helicobacter | pmid:25585658 |
Spaniol V et al. | Moraxella catarrhalis AcrAB-OprM efflux pump contributes to antimicrobial resistance and is enhanced during cold shock response. | 2015 | Antimicrob. Agents Chemother. | pmid:25583725 |
Chu HS et al. | Nontuberculous mycobacterial ocular infections--comparing the clinical and microbiological characteristics between Mycobacterium abscessus and Mycobacterium massiliense. | 2015 | PLoS ONE | pmid:25581038 |
Lee HJ et al. | Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies. | 2015 | World J. Gastroenterol. | pmid:25574111 |
Brown-Elliott BA et al. | Absence of a functional erm gene in isolates of Mycobacterium immunogenum and the Mycobacterium mucogenicum group, based on in vitro clarithromycin susceptibility. | 2015 | J. Clin. Microbiol. | pmid:25568437 |
Frija-Masson J et al. | [Non-tuberculous mycobacterial infection of a totally implanted perfusion device]. | 2015 | Rev Mal Respir | pmid:25480387 |
Lee H et al. | Comparison of efficacy and safety of levofloxacin-containing versus standard sequential therapy in eradication of Helicobacter pylori infection in Korea. | 2015 | Dig Liver Dis | pmid:25467826 |
Kobayashi M et al. | A sudden cardiac death induced by sildenafil and sexual activity in an HIV patient with drug interaction, cardiac early repolarization, and arrhythmogenic right ventricular cardiomyopathy. | 2015 | Int. J. Cardiol. | pmid:25464498 |
Boltin D et al. | Trends in secondary antibiotic resistance of Helicobacter pylori from 2007 to 2014: has the tide turned? | 2015 | J. Clin. Microbiol. | pmid:25428158 |
Zhang L et al. | [Minocycline quadruple versus tailored therapy in retreatment of Helicobacter pylori infection]. | 2015 | Zhonghua Nei Ke Za Zhi | pmid:26887366 |
Moriya S et al. | Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells. | 2015 | Int. J. Oncol. | pmid:25422130 |
Dierig A et al. | Antibiotic treatment of pertussis: are 7 days really sufficient? | 2015 | Pediatr. Infect. Dis. J. | pmid:25247586 |
Zhang Y et al. | Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China. | 2015 | Carcinogenesis | pmid:26449252 |
Mailleux M et al. | Unusual pulmonary toxicity of ipilimumab treated by macrolides. | 2015 | Acta Clin Belg | pmid:26790556 |
Gisbert JP et al. | Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy. | 2015 | Dig. Dis. Sci. | pmid:25236423 |
Ersal T et al. | Fatal disseminated infection with Fusarium petroliphilum. | 2015 | Mycopathologia | pmid:25234793 |
Tongtawee T et al. | High Prevalence of Helicobacter pylori Resistance to Clarithromycin: a Hospital-Based Cross-Sectional Study in Nakhon Ratchasima Province, Northeast of Thailand. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26745073 |
Baumann M et al. | Aquatic toxicity of the macrolide antibiotic clarithromycin and its metabolites. | 2015 | Chemosphere | pmid:25051235 |
Shin SH et al. | Helicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia. | 2015 | PLoS ONE | pmid:26580072 |
Desai S et al. | The Epidemiology of Invasive Haemophilus influenzae Non-Serotype B Disease in Ontario, Canada from 2004 to 2013. | 2015 | PLoS ONE | pmid:26569613 |
Kakked GA et al. | Pneumobilia with gastric outlet obstruction. | 2015 | BMJ Case Rep | pmid:26552878 |
Kim SE et al. | Trends in Helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy. | 2015 | Korean J. Intern. Med. | pmid:26552455 |
Bang CS and Baik GH | Time to learn from the past and prepare for the future in Helicobacter pylori eradication. | 2015 | Korean J. Intern. Med. | pmid:26552453 |
Alimadadi M et al. | Impact of creatinine clearance on Helicobacter pylori eradication rate in patients with peptic ulcer disease. | 2015 | Iran J Kidney Dis | pmid:26552348 |
Karpiński TM et al. | Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland. | 2015 | Acta Microbiol Immunol Hung | pmid:26551571 |
John A et al. | Does emerging Clarithromycin resistance signal an obituary to empirical standard triple therapy for Helicobacter pylori infection? | 2015 | Indian J Gastroenterol | pmid:26541342 |
Mel-Hennawi D and Ahmed MR | Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion. | 2015 | J Laryngol Otol | pmid:26521817 |
Nishizawa T et al. | Clarithromycin Versus Metronidazole as First-line Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Controlled Study in Japan. | 2015 | J. Clin. Gastroenterol. | pmid:24921211 |
Rubio M et al. | Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Complex. | 2015 | PLoS ONE | pmid:26448181 |
Blair PW et al. | DRESS syndrome presenting after initiation of mycobacterium avium complex osteomyelitis treatment. | 2015 | BMJ Case Rep | pmid:26438676 |
Chen KY et al. | Hybrid vs sequential therapy for eradication of Helicobacter pylori in Taiwan: A prospective randomized trial. | 2015 | World J. Gastroenterol. | pmid:26420970 |
Apiwattankul N et al. | Infections Caused by Rapidly Growing Mycobacteria spp in Children and Adolescents With Cancer. | 2015 | J Pediatric Infect Dis Soc | pmid:26407409 |
Hwang JJ et al. | Efficacy of moxifloxacin-based sequential and hybrid therapy for first-line Helicobacter pylori eradication. | 2015 | World J. Gastroenterol. | pmid:26401089 |
Weiss S et al. | Efficacy of Single and Combined Antibiotic Treatments of Anthrax in Rabbits. | 2015 | Antimicrob. Agents Chemother. | pmid:26392505 |
Hauser G et al. | Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. | 2015 | Medicine (Baltimore) | pmid:25929897 |
Zhi D et al. | The enhancement of cardiac toxicity by concomitant administration of Berberine and macrolides. | 2015 | Eur J Pharm Sci | pmid:25976224 |
Vliegenthart AD et al. | Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. | 2015 | Sci Rep | pmid:26489516 |
Renvoisé A et al. | Assessing primary and secondary resistance to clarithromycin and amikacin in infections due to Mycobacterium avium complex. | 2015 | Antimicrob. Agents Chemother. | pmid:26324275 |
Dingemanse C et al. | Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice. | 2015 | Carcinogenesis | pmid:26320104 |
Obregón-Henao A et al. | Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models. | 2015 | Antimicrob. Agents Chemother. | pmid:26303795 |
Pea F et al. | Everolimus overexposure in a heart transplant patient receiving clarithromycin for the treatment of pneumonia. | 2015 | Transpl Infect Dis | pmid:26296391 |
Picoli SU et al. | Resistance to amoxicillin, clarithromycin and ciprofloxacin of Helicobacter pylori isolated from Southern Brazil patients. | 2014 May-Jun | Rev. Inst. Med. Trop. Sao Paulo | pmid:24878996 |
UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
Skvarc M et al. | Multi locus sequence typing (MLST) used as a tool to confirm the ability of susceptible Helicobacter pylori strains to gain resistance to clarithromycin during eradication therapy. | 2014 Jan-Feb | Hepatogastroenterology | pmid:24895826 |
Yakoob J et al. | Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori. | 2014 | Microb. Drug Resist. | pmid:23844851 |
Khoshnood A et al. | Replacement of clarithromycin with azithromycin in triple therapy regimens for the eradication of Helicobacter pylori: A randomized clinical trial. | 2014 | J Med Life | pmid:25408735 |
Ueda Y et al. | [Obstructive pneumonia and brain abscess due to Nocardia elegans in a patient with systemic lupus erythematosus]. | 2014 | Kansenshogaku Zasshi | pmid:24974451 |
Heo J and Jeon SW | [Changes in the eradication rate of conventional triple therapy for Helicobacter pylori infection in Korea]. | 2014 | Korean J Gastroenterol | pmid:24651586 |
Kang BK et al. | [New therapeutic strategies against Helicobacter pylori]. | 2014 | Korean J Gastroenterol | pmid:24651587 |
Mendu ML and Waikar SS | Drug-drug interactions and acute kidney injury: caveat prescriptor. | 2014 | Am. J. Kidney Dis. | pmid:24820318 |
Furuta T et al. | Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan. | 2014 | J. Gastroenterol. Hepatol. | pmid:24224808 |
Noguchi S et al. | Polymorphic transformation of antibiotic clarithromycin under acidic condition. | 2014 | J Pharm Sci | pmid:24375227 |
Iwanczak B et al. | Genotypic and clinical differences of seropositive Helicobacter pylori children and adults in the Polish population. | 2014 | J. Physiol. Pharmacol. | pmid:25554984 |
Morakul B et al. | Dissolution enhancement and in vitro performance of clarithromycin nanocrystals produced by precipitation-lyophilization-homogenization method. | 2014 | Eur J Pharm Biopharm | pmid:25201298 |
Parekh TM et al. | Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas. | 2014 | JAMA Intern Med | pmid:25179404 |
Lambert D et al. | Gastritis due to Helicobacter pylori, an unusual cause of chronic diarrhoea in HIV infected patients. | 2014 | Med Mal Infect | pmid:25015308 |
Wang Y et al. | Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. | 2014 | Helicobacter | pmid:24826809 |
Mark TM et al. | Thalidomide, clarithromycin, lenalidomide and dexamethasone therapy in newly diagnosed, symptomatic multiple myeloma. | 2014 | Leuk. Lymphoma | pmid:24576165 |
Takazono T et al. | Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report. | 2014 | BMC Infect. Dis. | pmid:24576098 |