clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim HY et al. | Allele-specific duplex polymerase chain reaction to differentiate Mycobacterium abscessus subspecies and to detect highly clarithromycin-resistant isolates. | Indian J Med Microbiol | pmid:27514964 | |
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Martins GM et al. | MOLECULAR DETECTION OF CLARITHROMYCIN AND FLUOROQUINOLONES RESISTANCE IN HELICOBACTER PYLORI INFECTION, DIRECTLY APPLIED TO GASTRIC BIOPSIES, IN AN URBAN BRAZILIAN POPULATION. | Arq Gastroenterol | pmid:27305419 | |
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Lage R et al. | Mycobacterium chelonae cutaneous infection in a patient with mixed connective tissue disease. | An Bras Dermatol | pmid:25672306 | |
Jeon JS et al. | Detection of clarithromycin-resistant by polymerase chain reaction using residual samples from rapid urease test. | Indian J Med Microbiol | pmid:29063887 | |
Hu JL et al. | Optimized high-dose amoxicillin-proton-pump inhibitor dual therapies fail to achieve high cure rates in China. | Saudi J Gastroenterol | pmid:28937021 | |
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Horiguchi T et al. | Antibacterial activity and clinical efficacy of sparfloxacin in Mycobacterium avium-intracellulare complex infection. | J. Int. Med. Res. | pmid:15458286 | |
Zhang SH et al. | The effect of virulence genotypes of on eradication therapy in children. | Saudi J Gastroenterol | pmid:29652033 | |
Kempen JH | Medical management of human immunodeficiency virus infection. | Indian J Ophthalmol | pmid:18711266 | |
Christodoulou C et al. | Quetiapine and clarithromycin-induced neuroleptic malignant syndrome. | Clin Neuropharmacol | pmid:25580921 | |
Feng L et al. | Sequential Therapy or Standard Triple Therapy for Helicobacter pylori Infection: An Updated Systematic Review. | Am J Ther | pmid:25569598 | |
Al Majid FM | Peritonitis due to Mycobacterium fortuitum following gastric banding. | Saudi J Gastroenterol | pmid:20339182 | |
Roig J et al. | 13--Antibiotic therapy of community-acquired pneumonia (CAP) caused by atypical agents. | Med Mal Infect | pmid:17095177 | |
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Bachir M et al. | Primary antibiotic resistance and its relationship with cagA and vacA genes in Helicobacter pylori isolates from Algerian patients. | Braz. J. Microbiol. | pmid:29452847 | |
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Arora S et al. | Amoxicillin loaded chitosan-alginate polyelectrolyte complex nanoparticles as mucopenetrating delivery system for h. Pylori. | Sci Pharm | pmid:21886911 | |
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Hasan SR et al. | Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of Helicobacter pylori. | Saudi J Gastroenterol | pmid:20065568 | |
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Mishra A et al. | A rare debilitating neurological adverse effect of ranolazine due to drug interaction with clarithromycin. | Indian J Pharmacol | pmid:25298587 | |
Lew EA | Clarithromycin, lansoprazole, and metronidazole eradicated Helicobacter pylori infection in chronic renal insufficiency. | ACP J. Club | pmid:15122860 | |
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pmid:11817788 | ||||
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Chang NL et al. | Clarithromycin-Induced Torsades de Pointes. | Am J Ther | pmid:25057773 | |
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Moreira C et al. | Symmetrical drug-related intertriginous and flexural exanthema induced by clarithromycin. | An Bras Dermatol | pmid:28954125 | |
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Cavkaytar O et al. | Testing for clarithromycin hypersensitivity: A diagnostic challenge in childhood. | J Allergy Clin Immunol Pract | pmid:26489714 | |
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Pachot JI et al. | Experimental estimation of the role of P-Glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model. | J Pharm Pharm Sci | pmid:12753725 | |
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Chen YI and Fallone CA | A 14-day course of triple therapy is superior to a 10-day course for the eradication of Helicobacter pylori: A Canadian study conducted in a 'real world' setting. | Can J Gastroenterol Hepatol | pmid:26301332 | |
Lin TY et al. | An open-label, randomized comparison of levofloxacin and amoxicillin/clavulanate plus clarithromycin for the treatment of hospitalized patients with community-acquired pneumonia. | Chang Gung Med J | pmid:17939262 | |
Radzikowska E et al. | Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. | Adv Clin Exp Med | pmid:28028949 |