clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Paffetti A et al. | [Clarithromycin in pediatric age. Personal experience]. | 1994 | Minerva Pediatr. | pmid:8084327 |
Saran BR et al. | Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin. | 1994 | Arch. Ophthalmol. | pmid:8085960 |
Ohgaki N | Bacterial biofilm in chronic airway infection. | 1994 | Kansenshogaku Zasshi | pmid:8138670 |
Yew WW et al. | Cholestatic hepatitis in a patient who received clarithromycin therapy for a Mycobacterium chelonae lung infection. | 1994 | Clin. Infect. Dis. | pmid:8086541 |
Zahid MA et al. | Mycobacterium chelonae (M. chelonae subspecies chelonae): report of a patient with a sporotrichoid presentation who was successfully treated with clarithromycin and ciprofloxacin. | 1994 | Clin. Infect. Dis. | pmid:8086568 |
Nishimura M et al. | [Therapeutic study on biofilm of the urinary tract using a severely complicated bladder model (biofilm model of the urinary tract)--experimental study using an automatic simulator of urinary antimicrobial agent concentration, and clinical study]. | 1994 | Kansenshogaku Zasshi | pmid:7909830 |
Labenz J | [Helicobacter pylori therapy with omeprazole and clarithromycin: current status]. | 1994 | Leber Magen Darm | pmid:7968179 |
Oteo JA et al. | Clarithromycin-induced thrombocytopenic purpura. | 1994 | Clin. Infect. Dis. | pmid:7888564 |
Mor N et al. | Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. | 1994 | Antimicrob. Agents Chemother. | pmid:7695255 |
Calì G et al. | [Clarithromycin in the treatment of oral infections]. | 1994 | Minerva Stomatol | pmid:7700226 |
Jones RN et al. | Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7924221 |
Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
Scaglione F et al. | Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. | 1994 May-Jun | Chemotherapy | pmid:7515782 |
O'Connor NK and Fris J | Clarithromycin-carbamazepine interaction in a clinical setting. | 1994 Nov-Dec | J Am Board Fam Pract | pmid:7847111 |
Cama VA et al. | Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. | 1994 Sep-Oct | J. Eukaryot. Microbiol. | pmid:7804227 |
Adamek RJ et al. | Modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of Helicobacter pylori infection. | 1995 | Am. J. Gastroenterol. | pmid:7801936 |
FDA approves Biaxin for MAC prophylaxis. Food and Drug Administration. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11363096 | |
Jaup BH and Norrby A | Low dose, short-term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcers. | 1995 | Am. J. Gastroenterol. | pmid:7771426 |
Musher DM | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778830 |
van der Meer JT and Danner SA | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778831 |
Burette A and Glupczynski Y | Helicobacter pylori: the place of the new macrolides in the eradication of the bacteria in peptic ulcer disease. | 1995 | Infection | pmid:7782116 |
Savarino V et al. | Helicobacter pylori eradication and reinfection. | 1995 | Lancet | pmid:7783564 |
Comley JC and Sterling AM | Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785975 |
Odenholt-Tornqvist I et al. | Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens. | 1995 | Antimicrob. Agents Chemother. | pmid:7695310 |
Struillou L et al. | Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785988 |
Fong IW et al. | Clarithromycin versus cefaclor in lower respiratory tract infections. The Canadian Bronchitis Study Group. | 1995 | Clin Invest Med | pmid:7788958 |
Goddard A and Logan R | One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. | 1995 | Eur J Gastroenterol Hepatol | pmid:7866804 |
Labenz J et al. | One-week low-dose triple therapy for the eradication of Helicobacter pylori infection. | 1995 | Eur J Gastroenterol Hepatol | pmid:7866820 |
Ives DV et al. | Impact of clarithromycin and azithromycin on patterns of treatment and survival among AIDS patients with disseminated Mycobacterium avium complex. | 1995 | AIDS | pmid:7755914 |
Weits J and Sprenger HG | [Surgical treatment of lymphadenitis caused by non-tuberculous mycobacteria in children]. | 1995 | Ned Tijdschr Geneeskd | pmid:8524431 |
Nash KA and Inderlied CB | Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. | 1995 | Antimicrob. Agents Chemother. | pmid:8592991 |
RamÃrez Ramos A | [Treatment of Helicobacter pylori infection: current status]. | 1995 | Rev Gastroenterol Peru | pmid:8520021 |
Savarino V et al. | What is the meaning of ranitidine in successful triple-therapy against Helicobacter pylori infection? | 1995 | Am. J. Gastroenterol. | pmid:8540537 |
Gustavson LE et al. | Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state. | 1995 | Antimicrob. Agents Chemother. | pmid:8540719 |
Gill CJ et al. | In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin. | 1995 | J. Antibiot. | pmid:7490222 |
Gelber RH | Successful treatment of a lepromatous patient with clarithromycin. | 1995 | Int. J. Lepr. Other Mycobact. Dis. | pmid:7730711 |
Spangler SK et al. | Susceptibilities of 201 anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin by oxyrase agar dilution and E test methodologies. | 1995 | J. Clin. Microbiol. | pmid:7615756 |
Midoneck SR and Etingin OR | Clarithromycin-related toxic effects of digoxin. | 1995 | N. Engl. J. Med. | pmid:7477159 |
Forslund T et al. | Disseminated cutaneous infection due to Mycobacterium chelonae in a patient with rheumatoid arthritis, amyloidosis, and renal failure. | 1995 | Nephrol. Dial. Transplant. | pmid:7478131 |
Cavalieri SJ et al. | Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. | 1995 | Antimicrob. Agents Chemother. | pmid:7492101 |
Englishby VL | Case reports of death associated with pseudomembranous colitis and clarithromycin. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496875 |
Schepp W | [Omeprazole + clarithromycin + metronidazole--a new standard for eradication of Helicobacter pylori]. | 1995 | Z Gastroenterol | pmid:7502558 |
Widgerow AD et al. | Atypical Mycobacterium and breast surgery. | 1995 | Ann Plast Surg | pmid:7486746 |
Tamaoki J et al. | Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections. | 1995 | Antimicrob. Agents Chemother. | pmid:7486901 |
Mushatt DM and Witzig RS | Successful treatment of Mycobacterium abscessus infections with multidrug regimens containing clarithromycin. | 1995 | Clin. Infect. Dis. | pmid:7620048 |
Vance E et al. | Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS. | 1995 | Antimicrob. Agents Chemother. | pmid:7574530 |
Singh N and Yu VL | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7632282 |
Fabry W et al. | Comparison of the E test and a proportion dilution method for susceptibility testing of Mycobacterium tuberculosis. | 1995 | Zentralbl. Bakteriol. | pmid:9810662 |
Ishii K et al. | A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. | 1995 | Biol. Pharm. Bull. | pmid:7550125 |
Harris AW et al. | Eradication of Helicobacter pylori with lansoprazole and clarithromycin. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605863 |
Katelaris PH et al. | A randomized prospective comparison of clarithromycin versus amoxycillin in combination with omeprazole for eradication of Helicobacter pylori. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605864 |
Yousfi MM et al. | Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection. | 1995 | Aliment. Pharmacol. Ther. | pmid:7605865 |
Chevalley GF et al. | [Uveitis associated with rifabutin treatment. Apropos of 3 patients]. | 1995 | Klin Monbl Augenheilkd | pmid:7609395 |
Blum AL et al. | [Functional dyspepsia: approaches to Helicobacter pylori eradication therapy]. | 1995 | Leber Magen Darm | pmid:7609589 |
Labenz J et al. | [Short-term triple therapy with pantoprazole, clarithromycin and metronidazole in eradication of Helicobacter pylori]. | 1995 | Leber Magen Darm | pmid:7609590 |
Reppun JI | From prontolyn to biaxin: the half-century of antibiotics. | 1995 | Hawaii Med J | pmid:7628918 |
Chin DP and Hopewell PC | How to treat bacteraemic Mycobacterium avium complex disease. | 1995 | Lancet | pmid:7564723 |
Kuhn SM et al. | Treatment of Mycobacterium marinum facial abscess using clarithromycin. | 1995 | Pediatr. Infect. Dis. J. | pmid:7567299 |
Tamaoki J et al. | Effects of macrolide antibiotics on neurally mediated contraction of human isolated bronchus. | 1995 | J. Allergy Clin. Immunol. | pmid:7722166 |
Conte JE et al. | Intrapulmonary pharmacokinetics of clarithromycin and of erythromycin. | 1995 | Antimicrob. Agents Chemother. | pmid:7726492 |
Forné M et al. | Impact of colloidal bismuth subnitrate in the eradication rates of Helicobacter pylori infection-associated duodenal ulcer using a short treatment regimen with omeprazole and clarithromycin: a randomized study. | 1995 | Am. J. Gastroenterol. | pmid:7733075 |
Tebas P et al. | Rapid development of resistance to clarithromycin following monotherapy for disseminated Mycobacterium chelonae infection in a heart transplant patient. | 1995 | Clin. Infect. Dis. | pmid:7742453 |
Teare JP et al. | Pseudomembranous colitis following clarithromycin therapy. | 1995 | Eur J Gastroenterol Hepatol | pmid:7743311 |
Pollak PT et al. | Delirium probably induced by clarithromycin in a patient receiving fluoxetine. | 1995 | Ann Pharmacother | pmid:7655131 |
Ozmen MM and Johnson CD | Is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for Helicobacter pylori eradication? | 1995 | Am. J. Gastroenterol. | pmid:7661197 |
Savarino V et al. | New insight in the mechanism of omeprazole antimicrobial combinations to eradicate Helicobacter pylori. | 1995 | Am. J. Gastroenterol. | pmid:7717343 |
Saito H et al. | Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice. | 1995 | Tuber. Lung Dis. | pmid:7718848 |
Hedenmo M and Eriksson BM | Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction and electrochemical detection. | 1995 | J Chromatogr A | pmid:7719451 |
Metz DC and Getz HD | Helicobacter pylori gastritis therapy with omeprazole and clarithromycin increases serum carbamazepine levels. | 1995 | Dig. Dis. Sci. | pmid:7720489 |
Schlossberg D | Azithromycin and clarithromycin. | 1995 | Med. Clin. North Am. | pmid:7791424 |
Moayyedi P et al. | Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574714 |
Fujioka T et al. | Peptic ulcer recurrence after Helicobacter pylori eradication: a 5-year follow-up study. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574733 |
Deltenre M et al. | Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574734 |
Fukuda Y et al. | Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574735 |
Rizzato G et al. | Efficacy of a three day course of azithromycin in moderately severe community-acquired pneumonia. | 1995 | Eur. Respir. J. | pmid:7789484 |
Graham DY | Clarithromycin for treatment of Helicobacter pylori infections. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574737 |
Takimoto T et al. | Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574739 |
Uemura N et al. | Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574740 |
Ishii K et al. | In vitro dissolution tests corresponding to the in vivo dissolution of clarithromycin tablets in the stomach and intestine. | 1995 | Chem. Pharm. Bull. | pmid:8575034 |
Diehl HG | [One week triple therapy for eradication of Helicobacter pylori infection: simple and effective]. | 1995 | Leber Magen Darm | pmid:8577220 |
Götz JM et al. | Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. | 1995 | Scand. J. Gastroenterol. Suppl. | pmid:8578230 |
Pavlopoulou J et al. | Randomized controlled study of clarithromycin versus cefaclor suspensions in the treatment of acute otitis media in children. | 1995 | J Chemother | pmid:8904139 |
Atkinson BA et al. | Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin. | 1995 | Antimicrob. Agents Chemother. | pmid:8619588 |
Ford A et al. | Clarithromycin-induced digoxin toxicity in a patient with AIDS. | 1995 | Clin. Infect. Dis. | pmid:8645810 |
Gidoh M and Saito H | [Present status of studies on antileprosy drugs]. | 1995 | Nihon Rai Gakkai Zasshi | pmid:8582877 |
Stafstrom CE et al. | Erythromycin-induced carbamazepine toxicity: a continuing problem. | 1995 | Arch Pediatr Adolesc Med | pmid:7827672 |
Gioulekas J and Hall A | Uveitis associated with rifabutin therapy. | 1995 | Aust N Z J Ophthalmol | pmid:11980079 |
Nishi K et al. | [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821993 |
Piersimoni C et al. | Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. | 1995 | J. Antimicrob. Chemother. | pmid:8830013 |
Labenz J et al. | High-dose omeprazole plus amoxicillin or clarithromycin cures Helicobacter pylori infection in duodenal ulcer disease. | 1995 | Digestion | pmid:7895926 |
Van Asselt GJ et al. | Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. | 1995 | J. Med. Microbiol. | pmid:7563004 |
Brown BA et al. | Clarithromycin-induced hepatotoxicity. | 1995 | Clin. Infect. Dis. | pmid:7795060 |
Raffi F et al. | Breakthrough cerebral toxoplasmosis in patients with AIDS who are being treated with clarithromycin. | 1995 | Clin. Infect. Dis. | pmid:7795062 |
Sharma PK and Tami TA | AIDS: lessons from the last decade and prospects for the future. | 1995 | Ear Nose Throat J | pmid:7796740 |
Researchers find new drugs to fight MAC. | 1995 | AIDS Alert | pmid:11362925 |