clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Gram-Negative Bacterial Infections D016905 16 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
IgA Deficiency D017098 2 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Tooth, Nonvital D019553 2 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Renal Insufficiency D051437 8 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Sacroiliitis D058566 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Auw-Hädrich C et al. [Clarithromycin for monotherapy of B-cell MALT lymphoma?]. 2013 Ophthalmologe pmid:24231914
Rezvanian E and Watson NF Kleine-levin syndrome treated with clarithromycin. 2013 J Clin Sleep Med pmid:24235906
Cosme A et al. Usefulness of antimicrobial susceptibility in the eradication of Helicobacter pylori. 2013 Clin. Microbiol. Infect. pmid:22512623
Srivastava S et al. Therapeutic drug management: is it the future of multidrug-resistant tuberculosis treatment? 2013 Eur. Respir. J. pmid:24293417
Gui J et al. [Drug sensitivity analysis of Mycobacterium chelonae and Mycobacterium abscessus and evaluation of Etest for susceptibility testing]. 2013 Zhonghua Jie He He Hu Xi Za Zhi pmid:24252731
AvÅŸar E et al. A multicenter, randomized, prospective study of 14-day ranitidine bismuth citrate- vs. lansoprazole-based triple therapy for the eradication of Helicobacter pylori in dyspeptic patients. 2013 Turk J Gastroenterol pmid:24254262
Smiley R et al. Comparative proteomics analysis of sarcosine insoluble outer membrane proteins from clarithromycin resistant and sensitive strains of Helicobacter pylori. 2013 J. Microbiol. pmid:24173641
Ma Y et al. Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo. 2013 Drug Deliv pmid:24032596
Boyanova L et al. Characterization of oral Helicobacter pylori strain by 4 methods. 2013 Diagn. Microbiol. Infect. Dis. pmid:24075629
Morakul B et al. Precipitation-lyophilization-homogenization (PLH) for preparation of clarithromycin nanocrystals: influencing factors on physicochemical properties and stability. 2013 Int J Pharm pmid:24076396
Siamas K and Khachemoune A Mycobacteria infection in an immunocompetent patient with no risk factors: evaluation and management of non-healing majocchi granuloma-type nodule. 2013 Dermatol. Online J. pmid:24021439
Xu Y et al. Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. 2013 Eur J Med Chem pmid:24021890
Ranganathan D et al. Mycobacterium fortuitum peritonitis in a patient receiving continuous ambulatory peritoneal dialysis. 2013 Saudi J Kidney Dis Transpl pmid:24029271
Lally L and Mannion L The potential for antimicrobials to adversely affect mental state. 2013 BMJ Case Rep pmid:23833088
Murai A et al. Mastitis caused by Mycobacterium kansasii infection in a dog. 2013 Vet Clin Pathol pmid:23808608
Berghaus LJ et al. Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi. 2013 Vet. Microbiol. pmid:23915992
Herath SC and Poole P Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD). 2013 Cochrane Database Syst Rev pmid:24288145
Gysel M et al. Torsades de pointes following clarithromycin treatment. 2013 Expert Rev Cardiovasc Ther pmid:24147515
Megraud F et al. Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. 2013 Gut pmid:22580412
[Clarithromycin therapy for patients with cystic fibrosis: a randomized controlled trial]. 2013 Jpn J Antibiot pmid:24930240
Khamraev AA et al. [State of mucosal barrier of the stomach after Helicobacter pylori eradication and ulcer healing in patients with duodenal ulcer disease]. 2013 Eksp Klin Gastroenterol pmid:24933985
Nykula TD and Furleta VV [Rationale for improved treatment of ulcerative disease complicated by chronic pyelonephritis]. 2013 Lik. Sprava pmid:25095689
Avci O et al. A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma. 2013 J Dermatolog Treat pmid:21923567
Jiang JW et al. Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. 2013 Bioorg. Med. Chem. Lett. pmid:23591116
Odagiri T et al. Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. 2013 J. Med. Chem. pmid:23409972
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Kale-Pradhan PB et al. The role of antimicrobials in Crohn's disease. 2013 Expert Rev Gastroenterol Hepatol pmid:23445237
Pasipanodya JG and Gumbo T Drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions. 2013 Am. J. Respir. Crit. Care Med. pmid:23457368
Sasaki H et al. Ten-year trend of the cumulative Helicobacter pylori eradication rate for the 'Japanese eradication strategy'. 2013 Digestion pmid:24356705
Yakoob J et al. Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan. 2013 BMC Gastroenterol pmid:23433429
Yuan Y et al. Optimum duration of regimens for Helicobacter pylori eradication. 2013 Cochrane Database Syst Rev pmid:24338763
Amin M et al. Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants. 2013 Molecules pmid:23434867
Ogata SK et al. High Helicobacter pylori resistance to metronidazole and clarithromycin in Brazilian children and adolescents. 2013 J. Pediatr. Gastroenterol. Nutr. pmid:23403439
Morgan DR et al. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities. 2013 JAMA pmid:23403682
Naserpour Farivar T et al. Prevalence of clarithromycin-resistant Helicobacter pylori in patients with chronic tonsillitis by allele-specific Scorpion real-time polymerase chain reaction assay. 2013 Laryngoscope pmid:23404672
Koh WJ et al. Treatment of refractory Mycobacterium avium complex lung disease with a moxifloxacin-containing regimen. 2013 Antimicrob. Agents Chemother. pmid:23478956
Mikamo H et al. [Infection and host reaction]. 2013 Jpn J Antibiot pmid:24649796
Komatsu S et al. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. 2013 Biochem. Biophys. Res. Commun. pmid:23792097
Zhen-Hua Z et al. Characterization of 23S rRNA gene mutation in primary and secondary clarithromycin-resistant Helicobacter pylori strains from East China. 2013 Turk J Gastroenterol pmid:23794337
Onal IK et al. What is the impact of Helicobacter pylori density on the success of eradication therapy: a clinico-histopathological study. 2013 Clin Res Hepatol Gastroenterol pmid:23796974
de Zeeuw J et al. Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection. 2013 Am. J. Trop. Med. Hyg. pmid:23836576
Janković B et al. Consolidation trend design based on Young's modulus of clarithromycin single crystals. 2013 Int J Pharm pmid:23872226
Lee G et al. Nodular bronchiectatic Mycobacterium avium complex pulmonary disease. Natural course on serial computed tomographic scans. 2013 Ann Am Thorac Soc pmid:23952847
Seyedmajidi S et al. Penbactam for Helicobacter pylori eradication: a randomised comparison of quadruple and triple treatment schedules in an Iranian population. 2013 Arab J Gastroenterol pmid:23622801
Kate V et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a systematic review of recent evidence. 2013 Drugs pmid:23625272
Kato H et al. Addition of clarithromycin to lenalidomide/low-dose dexamethasone was effective in a case of relapsed myeloma after long-term use of lenalidomide. 2013 Ann. Hematol. pmid:23625297
Bolhuis MS et al. Clinical validation of the analysis of linezolid and clarithromycin in oral fluid of patients with multidrug-resistant tuberculosis. 2013 Antimicrob. Agents Chemother. pmid:23689722
Seddik H et al. Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a prospective randomized study. 2013 Eur. J. Clin. Pharmacol. pmid:23695545
Ohe M and Hashino S Successful treatment of recurrent follicular B-cell lymphoma with clarithromycin, prednisolone, and cyclophosphamide. 2013 Korean J. Intern. Med. pmid:23682236
Dib J et al. Efficacy of PPI, levofloxacin and amoxicillin in the eradication of Helicobacter pylori compared to conventional triple therapy at a Venezuelan hospital. 2013 Arab J Gastroenterol pmid:24206741
Sadeghifard N et al. Survey in Iran of clarithromycin resistance in Helicobacter pylori isolates by PCR-RFLP. 2013 Southeast Asian J. Trop. Med. Public Health pmid:23682442
Serelis J et al. Granulomatous infection of the hand and wrist due to Azospirillum spp. 2013 Diagn. Microbiol. Infect. Dis. pmid:23685031
Cerqueira L et al. Validation of a fluorescence in situ hybridization method using peptide nucleic acid probes for detection of Helicobacter pylori clarithromycin resistance in gastric biopsy specimens. 2013 J. Clin. Microbiol. pmid:23596234
Gibbins NE et al. Time to reconsider guidelines on clarithromycin in chronic rhinosinusitis? 2013 BMJ pmid:23635541
Pilcer G et al. Carrier-free combination for dry powder inhalation of antibiotics in the treatment of lung infections in cystic fibrosis. 2013 Int J Pharm pmid:23643509
Rimbara E et al. Helicobacter cinaedi and Helicobacter fennelliae transmission in a hospital from 2008 to 2012. 2013 J. Clin. Microbiol. pmid:23658263
Bismuth + metronidazole + tetracycline. Why risk adding bismuth? 2013 Prescrire Int pmid:23662315
Togami K et al. Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. 2013 Biol. Pharm. Bull. pmid:23995662
Bessa LJ et al. Helicobacter pylori free-living and biofilm modes of growth: behavior in response to different culture media. 2013 APMIS pmid:23237527
Qvist T et al. First report of lung transplantation in a patient with active pulmonary Mycobacterium simiae infection. 2013 Transplant. Proc. pmid:23267789
Fiorini G et al. Culture-based selection therapy for patients who did not respond to previous treatment for Helicobacter pylori infection. 2013 Clin. Gastroenterol. Hepatol. pmid:23267869
Kute VB et al. Bronchiolitis obliterans organizing pneumonia (BOOP) after renal transplantation. 2013 Int Urol Nephrol pmid:22547135
Vu DH et al. Troubleshooting carry-over of LC-MS/MS method for rifampicin, clarithromycin and metabolites in human plasma. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23353809
Kim SG et al. Helicobacter pylori eradication on iatrogenic ulcer by endoscopic resection of gastric tumour: a prospective, randomized, placebo-controlled multi-centre trial. 2013 Dig Liver Dis pmid:23333104
Lim JH et al. Clinical outcomes of two-week sequential and concomitant therapies for Helicobacter pylori eradication: a randomized pilot study. 2013 Helicobacter pmid:23305083
James GD et al. Use of long-term antibiotic treatment in COPD patients in the UK: a retrospective cohort study. 2013 Prim Care Respir J pmid:23839240
Dumpis U et al. Assessment of antibiotic prescribing in Latvian general practitioners. 2013 BMC Fam Pract pmid:23311389
Huang CW et al. Synergistic activities of tigecycline with clarithromycin or amikacin against rapidly growing mycobacteria in Taiwan. 2013 Int. J. Antimicrob. Agents pmid:23312605
Liu X et al. Clarithromycin-loaded liposomes offering high drug loading and less irritation. 2013 Int J Pharm pmid:23337631
Shinde DD et al. Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects. 2013 J Clin Pharmacol pmid:23381968
Singh RP et al. Antimicrobial prophylaxis in open reduction and internal fixation of compound mandibular fractures: a collaborative regional audit of outcome. 2013 Br J Oral Maxillofac Surg pmid:23369782
Prasertpetmanee S et al. Improved efficacy of proton pump inhibitor - amoxicillin - clarithromycin triple therapy for Helicobacter pylori eradication in low clarithromycin resistance areas or for tailored therapy. 2013 Helicobacter pmid:23356886
Chodkiewicz HM and Cohen PR Erythrasma: successful treatment after single-dose clarithromycin. 2013 Int. J. Dermatol. pmid:23046434
Lin KJ et al. Safety of macrolides during pregnancy. 2013 Am. J. Obstet. Gynecol. pmid:23254249
Jouneau S et al. Clarithromycin stops lung function decline in airway-centered interstitial fibrosis. 2013 Respiration pmid:23095475
Higashida A et al. Effectiveness of esomeprazole-based triple therapy of H. pylori in young patients in Japan. 2013 Scand. J. Gastroenterol. pmid:23016956
Kim MS et al. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. 2013 Helicobacter pmid:23066652
Xiong LJ et al. Detection of clarithromycin-resistant Helicobacter pylori by stool PCR in children: a comprehensive review of literature. 2013 Helicobacter pmid:23067446
Kupcinskas L et al. Evolution of Helicobacter pylori susceptibility to antibiotics during a 10-year period in Lithuania. 2013 APMIS pmid:23078193
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Koh WJ et al. Reply: drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions. 2013 Am. J. Respir. Crit. Care Med. pmid:23577353
Schmitt BH et al. PCR detection of clarithromycin-susceptible and -resistant Helicobacter pylori from formalin-fixed, paraffin-embedded gastric biopsies. 2013 Mod. Pathol. pmid:23579617
Tsuji D et al. Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin. 2013 Chemotherapy pmid:25011542
Joosten M et al. Case report: Helicobacter suis infection in a pig veterinarian. 2013 Helicobacter pmid:23551953
Gisbert JP et al. Second-line rescue triple therapy with levofloxacin after failure of non-bismuth quadruple "sequential" or "concomitant" treatment to eradicate H. pylori infection. 2013 Scand. J. Gastroenterol. pmid:23556551
Pilcer G et al. New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients. 2013 J Pharm Sci pmid:23568616
Feng Z et al. Dissociative disorder induced by clarithromycin combined with rabeprazole in a patient with gastritis. 2013 J. Int. Med. Res. pmid:23569151
Gokmen T et al. Clarithromycin treatment in preterm infants: a pilot study for prevention of feeding intolerance. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23570248
Metzler K et al. Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae. 2013 J. Antimicrob. Chemother. pmid:23169894
Semino-Mora C et al. Antibiotic treatment decreases microbial burden associated with pseudomyxoma peritonei and affects β-catenin distribution. 2013 Clin. Cancer Res. pmid:23743566
Cai M et al. Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia. 2013 Immunobiology pmid:23199585
Zullo A et al. Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study. 2013 Clin Res Hepatol Gastroenterol pmid:23747131
Markert C et al. Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1. 2013 Eur. J. Clin. Pharmacol. pmid:23748747
Nishizawa T et al. Delay of second-line eradication therapy for Helicobacter pylori can increase eradication failure. 2013 J. Gastroenterol. Hepatol. pmid:23701705
Lands LC and Stanojevic S Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis. 2013 Cochrane Database Syst Rev pmid:23765216
Kwon HJ et al. Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant. 2013 J. Trop. Pediatr. pmid:22735791
Liu MK et al. Randomized trial comparing rabeprazole- versus lansoprazole-based Helicobacter pylori eradication regimens. 2013 Kaohsiung J. Med. Sci. pmid:23768702
Li XM et al. Telithromycin versus clarithromycin for the treatment of community-acquired respiratory tract infections: a meta-analysis of randomized controlled trials. 2013 Chin. Med. J. pmid:23769580
Asaoka D et al. Trends of second-line eradication therapy for Helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area. 2013 Helicobacter pmid:23773231