clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Gram-Negative Bacterial Infections D016905 16 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
IgA Deficiency D017098 2 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Tooth, Nonvital D019553 2 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Renal Insufficiency D051437 8 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Sacroiliitis D058566 1 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Young A Hold the big MAC. 1996 Notes Undergr pmid:11363450
High-dose clarithromycin should be avoided. 1996 AIDS Alert pmid:11363723
Pot shots. 1996 Notes Undergr pmid:11363915
Bowersox J CPCRA researchers present OI studies at Vancouver. 1996 NIAID AIDS Agenda pmid:11363924
MAC management. 1996 PI Perspect pmid:11363967
Vasquez A et al. Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University. 1996 J. Clin. Microbiol. pmid:8727909
O'Hara K and Yamamoto K Reaction of roxithromycin and clarithromycin with macrolide-inactivating enzymes from highly erythromycin-resistant Escherichia coli. 1996 Antimicrob. Agents Chemother. pmid:8849224
Darouiche RO et al. Recurrent disseminated infection with Mycobacterium avium complex identified in tissues by molecular analysis. 1996 Clin. Infect. Dis. pmid:8729215
Flurer CL Analysis of macrolide antibiotics by capillary electrophoresis. 1996 Electrophoresis pmid:8900943
Gillum JG et al. Effect of clarithromycin on the pharmacokinetics of 2',3'-dideoxyinosine in patients who are seropositive for human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8729217
Dalla Libera M et al. High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication. 1996 Aliment. Pharmacol. Ther. pmid:8730251
Labenz J et al. One-week triple therapy with omeprazole, amoxycillin and either clarithromycin or metronidazole for cure of Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8730252
Vermot D et al. Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis. 1996 Antimicrob. Agents Chemother. pmid:8851620
Craig AM et al. Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin. 1996 Pharmacoeconomics pmid:10160472
Cadranel JF et al. [Acute symptomatic cytolytic hepatitis probably related to clarithromycin]. 1996 Gastroenterol. Clin. Biol. pmid:9119179
Labenz J [Helicobacter pylori eradication: finally clarity]. 1996 Leber Magen Darm pmid:9082109
Hultén K et al. New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. 1996 Antimicrob. Agents Chemother. pmid:9124830
Conte JE et al. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. 1996 Antimicrob. Agents Chemother. pmid:8807050
Xu G et al. Effect of macrolide antibiotics on macrophage functions. 1996 Microbiol. Immunol. pmid:8865152
McCutchan JA Azithromycin in the prophylaxis of opportunistic infections in AIDS. 1996 Int J STD AIDS pmid:8652726
Tursi A et al. Evaluation of the efficacy and tolerability of four different therapeutic regimens for the Helicobacter pylori eradication. 1996 Panminerva Med pmid:9009677
MacFarlane JT et al. Comparison of amoxycillin and clarithromycin as initial treatment of community-acquired lower respiratory tract infections. 1996 Br J Gen Pract pmid:8983255
Hachem CY et al. Antimicrobial susceptibility testing of Helicobacter pylori. Comparison of E-test, broth microdilution, and disk diffusion for ampicillin, clarithromycin, and metronidazole. 1996 Diagn. Microbiol. Infect. Dis. pmid:8988762
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Torresin A et al. Vinca alkaloids and macrolides in human immunodeficiency virus-related malignancies: a safe association. 1996 Cancer Chemother. Pharmacol. pmid:8995518
van Zwet AA et al. Prevalence of primary Helicobacter pylori resistance to metronidazole and clarithromycin in The Netherlands. 1996 Eur. J. Clin. Microbiol. Infect. Dis. pmid:8997557
Drouet M et al. [Unusual clinical form of amoxicillin allergy]. 1996 Allerg Immunol (Paris) pmid:9011169
Thompson D and Oster G Use of terfenadine and contraindicated drugs. 1996 JAMA pmid:8614120
Clarithromycin and omeprazole for Helicobacter pylori. 1996 Med Lett Drugs Ther pmid:8637481
Asnis DS et al. Mycobacterium avium-intracellulare complex pneumonia in a non-HIV-infected individual: an increasingly recognized disease. 1996 South. Med. J. pmid:8638183
Spadaccini A et al. Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers. 1996 Aliment. Pharmacol. Ther. pmid:8899094
Schütze K et al. Clarithromycin or amoxycillin plus high-dose ranitidine in the treatment of Helicobacter pylori-positive functional dyspepsia. 1996 Eur J Gastroenterol Hepatol pmid:8900907
Kondoh K et al. Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa. 1996 Acta Otolaryngol Suppl pmid:8908271
Moreno JA et al. Significant increase in eradication rates of Helicobacter pylori infection with two consecutive dual therapies (omeprazole and amoxycillin or omeprazole and clarithromycin). A randomized study in 450 Spanish patients. 1996 J. Gastroenterol. pmid:8959519
Satoh K et al. Efficacy of clarithromycin in eradicating Helicobacter pylori. 1996 J. Gastroenterol. pmid:8959520
Shimoyama T et al. Ecabet sodium eradicates Helicobacter pylori infection in gastric ulcer patients. 1996 J. Gastroenterol. pmid:8959522
Plemmons RM et al. Otitis media and mastoiditis due to Mycobacterium fortuitum: case report, review of four cases, and a cautionary note. 1996 Clin. Infect. Dis. pmid:8783722
Bagarazzi ML et al. Pulmonary Mycobacterium gordonae infection in a two-year-old child: case report. 1996 Clin. Infect. Dis. pmid:8783736
Santander C et al. Antimicrobial therapy for Helicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: prospective nonrandomized trial on 125 patients. 1996 Am. J. Gastroenterol. pmid:8759659
Tursi A et al. Short-term low-dose triple therapy with lansoprazole plus amoxycillin and clarithromycin for Helicobacter pylori eradication. 1996 Am. J. Gastroenterol. pmid:8759696
Debets-Ossenkopp YJ et al. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori. 1996 FEMS Microbiol. Lett. pmid:8759787
Géhanno P et al. [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. 1996 Pathol. Biol. pmid:8763594
Jordan WC Clarithromycin prophylaxis against Cryptosporidium enteritis in patients with AIDS. 1996 J Natl Med Assoc pmid:8764523
Yousfi MM et al. Resolution of a metaplastic duodenal polyp after cure of Helicobacter pylori infection. 1996 J. Clin. Gastroenterol. pmid:8835902
Yousfi MM et al. Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). 1996 Aliment. Pharmacol. Ther. pmid:8871452
Fisher M et al. The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group. 1996 Int J STD AIDS pmid:8876354
Rastogi N et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. 1996 Curr. Microbiol. pmid:8672093
Blomgren K and Alván G [New guidelines from the Medical Products Agency: the triple regime against Helicobacter pylori is necessary. Treat only if the ulcer is verified]. 1996 Lakartidningen pmid:8656812
Welsh L et al. In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. 1996 Antimicrob. Agents Chemother. pmid:8787907
Bachelez H et al. Disseminated varioliform pustular eruption due to Mycobacterium avium intracellulare in an HIV-infected patient. 1996 Br. J. Dermatol. pmid:8733397
Mehaffey PC et al. Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. 1996 J. Clin. Microbiol. pmid:8789046
Heifets LB Clarithromycin against Mycobacterium avium complex infections. 1996 Tuber. Lung Dis. pmid:8733409
Deltenre M et al. [How to eradicate Helicobacter pylori in 1995? Critical review of available treatments]. 1996 Gastroenterol. Clin. Biol. pmid:8734370
Cayla R [How to eradicate Helicobacter pylori?]. 1996 Gastroenterol. Clin. Biol. pmid:8734380
Koga T et al. In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8737142
Lebrun L et al. Evaluation of the Etest for rapid susceptibility testing of Mycobacterium avium to clarithromycin. 1996 J. Antimicrob. Chemother. pmid:8737150
Markham A and McTavish D Clarithromycin and omeprazole as helicobacter pylori eradication therapy in patients with H. pylori-associated gastric disorders. 1996 Drugs pmid:8741237
Unge P Review of Helicobacter pylori eradication regimens. 1996 Scand. J. Gastroenterol. Suppl. pmid:8722388
Amsden GW Erythromycin, clarithromycin, and azithromycin: are the differences real? 1996 Jan-Feb Clin Ther pmid:8851453
Sander P et al. Ribosomal drug resistance in mycobacteria. 1996 Jan-Feb Res. Microbiol. pmid:8761724
Papp J et al. Efficacy of nizatidine, clarithromycin and bismuth subcitrate therapy for Helicobacter pylori eradication in duodenal ulcer patients--a preliminary report. 1996 Jul-Aug Br J Clin Pract pmid:8794601
Tursi A et al. One-week low-dose triple therapy vs. two-week medium-dose double therapy for H.pylori infection. 1996 Jul-Aug Hepatogastroenterology pmid:8884304
Sketris IS et al. Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction. 1996 Mar-Apr Pharmacotherapy pmid:8820476
Akamatsu H et al. Enhanced effect of clarithromycin on neutrophil function in vitro. 1996 Mar-Apr J. Int. Med. Res. pmid:8737228
Nightingale SL From the Food and Drug Administration. 1996 May 22-29 JAMA pmid:8622234
Prescott LM Clarithromycin for MAC prevention offers additional benefits. 1996 May-Jun Posit Aware pmid:11363431
Mertl SL The role of clarithromycin in the prophylaxis of disseminated Mycobacterium avium-intracellulare infection in patients with AIDS. 1996 May-Jun Pharmacotherapy pmid:8726597
Ono T et al. In vitro and in vivo antibacterial activities of clarithromycin. 1996 May-Jun Chemotherapy pmid:8983882
Peeling RW and Brunham RC Chlamydiae as pathogens: new species and new issues. 1996 Oct-Dec Emerging Infect. Dis. pmid:8969247
Phull PS et al. Lansoprazole plus clarithromycin: evaluation of a new dual therapy for Helicobacter pylori eradication. 1996 Oct-Nov Br J Clin Pract pmid:9015906
Marignani M et al. Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori infection. 1997 Scand. J. Gastroenterol. pmid:9200297
Kato S et al. Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. 1997 Pediatrics pmid:9200377
Woo MS et al. Pediatric transplant grand rounds. A case presentation: skin lesions in a post-lung transplant patient. 1997 Pediatr Transplant pmid:10084776
Gisbert JP et al. [What is the current role of clarithromycin in the eradication of Helicobacter pylori?]. 1997 Rev Esp Enferm Dig pmid:9221019
Taylor DE et al. Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. 1997 Antimicrob. Agents Chemother. pmid:9420030
Spinzi G et al. Randomized study comparing omeprazole plus amoxycillin versus omeprazole plus clarithromycin for eradication of Helicobacter pylori. 1997 Aliment. Pharmacol. Ther. pmid:9146769
Peterson WL The role of antisecretory drugs in the treatment of Helicobacter pylori infection. 1997 Aliment. Pharmacol. Ther. pmid:9146787
Chaisson RE et al. Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. 1997 AIDS pmid:9147422
Lazzaroni M et al. Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer. 1997 Am. J. Gastroenterol. pmid:9128316
Pendland SL et al. Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. 1997 J. Clin. Microbiol. pmid:9350781
Burman WJ et al. A retrospective comparison of clarithromycin versus rifampin in combination treatment for disseminated Mycobacterium avium complex disease in AIDS: clarithromycin decreases transfusion requirements. 1997 Int. J. Tuberc. Lung Dis. pmid:9441082
Brady RC et al. Facial sporotrichoid infection with Mycobacterium marinum. 1997 J. Pediatr. pmid:9042142
Suzuki K et al. Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages. 1997 Int. J. Tuberc. Lung Dis. pmid:9441102
Axon AT et al. Ranitidine bismuth citrate and clarithromycin twice daily in the eradication of Helicobacter pylori. 1997 Aliment. Pharmacol. Ther. pmid:9042977
Zuberi BF et al. Low dose, short-term, triple therapy for helicobacter pylori associated peptic ulcer. 1997 J Pak Med Assoc pmid:9361485
Zullo A et al. Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study. 1997 Am. J. Gastroenterol. pmid:9362185
Buckley MJ et al. Metronidazole resistance reduces efficacy of triple therapy and leads to secondary clarithromycin resistance. 1997 Dig. Dis. Sci. pmid:9365144
Price J and Hamilton W Pragmatic eradication of H. pylori. 1997 Br J Gen Pract pmid:9474836
Cammarota G et al. Regression of a primary gastric MALT lymphoma with extensive antrum lesions by Helicobacter pylori eradication. 1997 Ital J Gastroenterol Hepatol pmid:9476192
Hotz J [Reflux disease of the gastrointestinal tract. Acute therapy and long-term care in daily practice. 2. Therapeutic procedure--diagnosis--therapy-diagram]. 1997 Fortschr. Med. pmid:9480263
Sousa C et al. [Cholestatic hepatitis probably induced by clarithromycin]. 1997 Gastroenterol. Clin. Biol. pmid:9587506
Barry AL et al. In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. 1997 Eur. J. Clin. Microbiol. Infect. Dis. pmid:9405952
Mitsuyama T et al. Neutrophil-induced endothelial cell damage: inhibition by a 14-membered ring macrolide through the action of nitric oxide. 1997 Int. Arch. Allergy Immunol. pmid:9338603
Walsh D et al. One week treatment for Helicobacter pylori infection. 1997 Arch. Dis. Child. pmid:9166031
Suzuki Y et al. [Antimicrobial activities of clarithromycin against recent obtained clinical isolates]. 1997 Jpn J Antibiot pmid:9394238
Ando H et al. [Changes in serum anti-Helicobacter pylori IgG antibody, pepsinogen I, and pepsinogen II after eradication therapy of Helicobacter pylori]. 1997 Nihon Shokakibyo Gakkai Zasshi pmid:9396326
Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. 1997 Gut pmid:9274464
Lam SK et al. Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study. 1997 Gut pmid:9274470
Hirakawa T [Diagnosis and treatment of Helicobacter pylori]. 1997 Nippon Ika Daigaku Zasshi pmid:9283206
Midolo PD et al. Antimicrobial resistance testing of Helicobacter pylori: a comparison of Etest and disk diffusion methods. 1997 Pathology pmid:9423225