clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Hyperemesis Gravidarum D006939 2 associated lipids
Empyema, Pleural D016724 2 associated lipids
Mastoiditis D008417 2 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Scrub Typhus D012612 3 associated lipids
Tuberculosis, Avian D014379 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Splenic Diseases D013158 5 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Leprosy, Lepromatous D015440 2 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
Hypoproteinemia D007019 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Tuberculosis, Ocular D014392 1 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Parotid Diseases D010305 1 associated lipids
Achlorhydria D000126 1 associated lipids
Eye Infections D015817 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Granuloma, Plasma Cell D006104 1 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Parotid Neoplasms D010307 2 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Tuberculosis, Spinal D014399 1 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Empyema, Tuberculous D004654 1 associated lipids
Serositis D012700 1 associated lipids
Glossitis, Benign Migratory D005929 1 associated lipids
Sacroiliitis D058566 1 associated lipids
Pseudomyxoma Peritonei D011553 1 associated lipids
Tooth, Nonvital D019553 2 associated lipids
Myxoma D009232 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Logan RP et al. Clarithromycin and omeprazole for Helicobacter pylori. 1992 Lancet pmid:1353155
Hammerschlag MR et al. In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. 1992 Antimicrob. Agents Chemother. pmid:1324650
Paulsen P et al. Influence of azithromycin and other macrolides on the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes of healthy donors and a patient with Chédiak-Higashi syndrome. 1992 Chemotherapy pmid:1324831
Ruf B et al. Acquired resistance of MAI to clarithromycin. 1992 Am. Rev. Respir. Dis. pmid:1533999
Berk SL New macrolide antibiotics. 1992 Ann. Intern. Med. pmid:1386966
de Lalla F et al. Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS. 1992 Antimicrob. Agents Chemother. pmid:1387303
Sturgill MG and Rapp RP Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. 1992 Ann Pharmacother pmid:1421677
Rastogi N et al. Activity of clarithromycin compared with those of other drugs against Mycobacterium paratuberculosis and further enhancement of its extracellular and intracellular activities by ethambutol. 1992 Antimicrob. Agents Chemother. pmid:1482157
Derouin F et al. Synergistic activity of clarithromycin and minocycline in an animal model of acute experimental toxoplasmosis. 1992 Antimicrob. Agents Chemother. pmid:1482160
Takeda H et al. [A study to clarify the mechanism of the usefulness of the macrolides--the influence of clarithromycin to biofilm with P. aeruginosa]. 1992 Kansenshogaku Zasshi pmid:1363435