clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sugano H et al. | [Helicobacter pylori eradication therapy for gastric ulcer in elderly]. | 2010 | Nippon Rinsho | pmid:21061532 |
Shirai T et al. | [Four kinds of new triple therapy regiments for Helicobacter pylori eradication in patients with peptic ulcer]. | 1999 | Nippon Rinsho | pmid:10036951 |
Nakagawa M et al. | [A comparative study; one week treatment versus two weeks treatment with lansoprazol, amoxycillin and clarythromycin for the eradication of Helicobacter pylori in patient with gastric and duodenal ulcer]. | 1999 | Nippon Rinsho | pmid:10036952 |
Kihira K et al. | [Triple therapy regimens involving H2 blockaders for therapy of Helicobacter pylori infections]. | 1999 | Nippon Rinsho | pmid:10036953 |
Kato M | [Expanded indication of National Health Insurance for H. pylori associated gastritis]. | 2014 | Nippon Rinsho | pmid:24912302 |
Nakajima S et al. | [Effect of probiotics on the prevention of diarrhea in Helicobacter pylori therapy]. | 2005 | Nippon Rinsho | pmid:16363597 |
Hikichi T et al. | [Influence of cytochrome P450 2C19 genetic polymorphism on H. pylori eradication therapy]. | 2005 | Nippon Rinsho | pmid:16363603 |
Take S et al. | [Influence of interleukin-1beta genetic polymorphism on H. pylori eradication therapy]. | 2005 | Nippon Rinsho | pmid:16363604 |
Kodama R et al. | [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. | 1993 | Nippon Rinsho | pmid:8283646 |
Watanabe T and Chiba T | [Clinical features of peptic ulcer disease in the elderly]. | 2002 | Nippon Rinsho | pmid:12187741 |
Nakamura T and Terano A | [Eradication therapy of Helicobacter pylori for elderly patients in Japan]. | 2002 | Nippon Rinsho | pmid:12187752 |
Iwabuchi H and Matsuzaki K | [The treatment of peptic ulcer in elderly CRF patients]. | 2002 | Nippon Rinsho | pmid:12187758 |
Nagai H | [Nontuberculous mycobacteriosis]. | 2003 | Nippon Rinsho | pmid:12722274 |
Asaka M | [Guidelines in the management of Helicobacter pylori infection in Japan]. | 2003 | Nippon Rinsho | pmid:12722304 |
Inoue K and Sugano K | [Eradication therapy for clarithromycin-resistant and metronidazole-resistant Helicobacter pylori infection]. | 2002 | Nippon Rinsho | pmid:11979828 |
Miwa H et al. | [Adverse effects of H. pylori eradication therapy and its measure]. | 2002 | Nippon Rinsho | pmid:11979829 |
Sakaki N | [Acute mucosal lesion of the upper-gastrointestinal tract observed after H. pylori-eradication]. | 2002 | Nippon Rinsho | pmid:11979830 |
Haruma K et al. | [H. pylori eradication therapy and natural history of peptic ulcer]. | 2002 | Nippon Rinsho | pmid:11979833 |
Sawada A | [Gastroduodenal ulcer in childhood]. | 2002 | Nippon Rinsho | pmid:11979854 |
Watanabe T and Chiba T | [Peptic ulcer in the elderly]. | 2002 | Nippon Rinsho | pmid:11979855 |
Sugano K | [Role of proton pump inhibitors in the eradication therapy for Helicobacter pylori (overviews)]. | 2002 | Nippon Rinsho | pmid:11979859 |
Iwasaki A | [Proton pump inhibitors: Omeprazole]. | 2002 | Nippon Rinsho | pmid:11979860 |
Kawata H and Satoh K | [Proton pump inhibitors: Efficacy of lansoprazole in eradicating Helicobacter pylori]. | 2002 | Nippon Rinsho | pmid:11979862 |
Inoue K et al. | [Antimicrobial resistant test of H. pylori]. | 2001 | Nippon Rinsho | pmid:11218400 |
Murakami K et al. | [Selection of antibiotics and planning of eradication for H. pylori infection]. | 2001 | Nippon Rinsho | pmid:11218403 |
Tanabe H et al. | [Usefulness of new triple therapy containing PPI]. | 2001 | Nippon Rinsho | pmid:11218404 |
Ohkusa T and Watanabe M | [A strategy for second-line anti-Helicobacter pylori therapy in patients with previously failed treatment]. | 2001 | Nippon Rinsho | pmid:11218406 |
Maeda S and Yoshida H | [Mechanism of drug resistance in Helicobacter pylori]. | 2001 | Nippon Rinsho | pmid:11218414 |
Kamiya S | [Helicobacter pylori infection and probiotics]. | 2007 | Nippon Saikingaku Zasshi | pmid:17575794 |
Keto Y et al. | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11680169 |
Young A | Hold the big MAC. | 1996 | Notes Undergr | pmid:11363450 |
Pot shots. | 1996 | Notes Undergr | pmid:11363915 | |
Navuluri R and Yue S | Understanding peptic ulcer disease pharmacotherapeutics. | 1999 | Nurse Pract | pmid:10100245 |
Wollner T | Eradicate H. pylori with effective treatment regimens. | 2004 | Nurse Pract | pmid:15257123 |
Holdcroft C | Two new macrolide antibiotics: clarithromycin and azithromycin. | 1993 | Nurse Pract | pmid:8380492 |
Shuster J | Clarithromycin and CNS disturbances. | 2001 | Nursing | pmid:11288564 |
Kiani J and Imam SZ | Medicinal importance of grapefruit juice and its interaction with various drugs. | 2007 | Nutr J | pmid:17971226 |
Bibi Z | Role of cytochrome P450 in drug interactions. | 2008 | Nutr Metab (Lond) | pmid:18928560 |
Bonfigli AR et al. | Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients. | 2016 | Nutr Metab Cardiovasc Dis | pmid:27480449 |
Abdullahi M et al. | The eradication of Helicobacter pylori is affected by body mass index (BMI). | 2008 | Obes Surg | pmid:18443890 |
Cerqueira RM et al. | Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery--fourteen days superior to seven days? | 2011 | Obes Surg | pmid:20838918 |
Callen EC and Kessler TL | Mycobacterium fortuitum infections associated with laparoscopic gastric banding. | 2011 | Obes Surg | pmid:20336391 |
Cerqueira RM et al. | Cumulative Helicobacter Pylori Eradication Rates by Adopting First- and Second- Line Regimens Proposed by the Maastricht IV Consensus in Obese Patients Undergoing Gastric Bypass Surgery. | 2018 | Obes Surg | pmid:29076008 |
Cerqueira RM et al. | How Effective Is the Quadruple Concomitant Helicobacter Pylori Eradication Therapy for Obese Patients Undergoing Gastric Bypass Surgery? | 2016 | Obes Surg | pmid:26467690 |
Cerqueira RM et al. | Cumulative Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery. | 2013 | Obes Surg | pmid:23054570 |
Liu DT et al. | Stenotrophomonas maltophilia and Mycobacterium chelonae coinfection of the extraocular scleral buckle explant. | 2007 Nov-Dec | Ocul. Immunol. Inflamm. | pmid:18085488 |
Stewart MW et al. | Visual recovery following Mycobacterium chelonae endophthalmitis. | 2006 | Ocul. Immunol. Inflamm. | pmid:16766402 |
Barros S et al. | Cat Scratch Disease: Not a Benign Condition. | 2018 | Ocul. Immunol. Inflamm. | pmid:28665750 |
Yamauchi Y et al. | Conjunctival flora in patients with human immunodeficiency virus infection. | 2005 Jul-Aug | Ocul. Immunol. Inflamm. | pmid:16159721 |
Madi D et al. | Successful treatment of cerebral toxoplasmosis with clindamycin: a case report. | 2012 | Oman Med J | pmid:23074553 |
Hiyama T et al. | c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. | 2001 Mar-Apr | Oncol. Rep. | pmid:11182042 |
Hiyama T et al. | Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication. | 2001 Mar-Apr | Oncol. Rep. | pmid:11182043 |
Adachi T et al. | Comparative Study of Clarithromycin- versus Metronidazole-Based Triple Therapy as First-Line Eradication for Helicobacter pylori. | 2017 | Oncology | pmid:29258111 |
Clarithromycin effectively treats infection in AIDS patients. | 1993 | Oncology (Williston Park, N.Y.) | pmid:8512782 | |
Feeney ER and Mallon PW | HIV and HAART-Associated Dyslipidemia. | 2011 | Open Cardiovasc Med J | pmid:21643501 |
Lee C et al. | A patient with shortness of breath and bilateral pulmonary infiltrates. | 2010 | Open Med | pmid:21687339 |
Eber E | Treatment of acute viral bronchiolitis. | 2011 | Open Microbiol J | pmid:22262989 |
Abdalla Abbas M et al. | Microbial risk factors of cardiovascular and cerebrovascular diseases: potential therapeutical options. | 2008 | Open Neurol J | pmid:19018303 |
Mc Laughlin AM et al. | Extensively drug-resistant tuberculosis (XDR-TB) - a potential threat in Ireland. | 2007 | Open Respir Med J | pmid:19340317 |
Fortún J et al. | Ca-125: a useful marker to distinguish pulmonary tuberculosis from other pulmonary infections. | 2009 | Open Respir Med J | pmid:19966922 |
Omurzakova NA et al. | Prevalence of Group A b-Hemolytic Streptococcus Among Children with Tonsillopharyngitis in Kyrgyzstan: The Difficulty of Diagnostics and Therapy. | 2010 | Open Rheumatol J | pmid:21253454 |
Mauriello JA | Atypical mycobacterial infection of the periocular region after periocular and facial surgery. | 2003 | Ophthalmic Plast Reconstr Surg | pmid:12918551 |
Auw-Hädrich C et al. | [Clarithromycin for monotherapy of B-cell MALT lymphoma?]. | 2013 | Ophthalmologe | pmid:24231914 |
Haas K | [Reply]. | 2013 | Ophthalmologe | pmid:24377112 |
Danilko L et al. | [Clarithromycin therapy of a B cell MALT lymphoma]. | 2013 | Ophthalmologe | pmid:23224128 |
Holzer MP et al. | [Diagnosis and treatment of mycobacterial keratitis following LASIK. Case report and review of the literature]. | 2003 | Ophthalmologe | pmid:12920556 |
Krasny J et al. | The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). | 2005 Jul-Aug | Ophthalmologica | pmid:16088243 |
Freitas D et al. | An outbreak of Mycobacterium chelonae infection after LASIK. | 2003 | Ophthalmology | pmid:12578767 |
Solomon A et al. | Mycobacterium interface keratitis after laser in situ keratomileusis. | 2001 | Ophthalmology | pmid:11733259 |
Klapper SR et al. | Atypical mycobacterial infection of the orbit. | 1995 | Ophthalmology | pmid:9097803 |
Klapper SR and Patrinely JR | Periocular atypical mycobacterial infections. | 1999 | Ophthalmology | pmid:10485521 |
Hamam RN et al. | Recalcitrant post-LASIK Mycobacterium chelonae keratitis eradicated after the use of fourth-generation fluoroquinolone. | 2006 | Ophthalmology | pmid:16647126 |
Karia N and Aylward GW | Postoperative proprionibacterium acnes endophthalmitis. | 2001 | Ophthalmology | pmid:11297461 |
Bhagat N et al. | Rifabutin-associated hypopyon uveitis in human immunodeficiency virus-negative immunocompetent individuals. | 2001 | Ophthalmology | pmid:11297492 |
Namiot Z et al. | Effect of antibacterial therapy and salivary secretion on the efficacy of Helicobacter pylori eradication in duodenal ulcer patients. | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:15184853 |
Avcu N et al. | The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B12-deficiency anemia. | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:11505263 |
Lindeboom JA et al. | First case of an oculofacial lesion due to Mycobacterium haemophilum infection in an immunocompetent child. | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:16731399 |
Lindeboom JA et al. | Clarithromycin as a single-modality treatment in mycobacterial avium-intracellular infections. | 1999 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:9927080 |
Suzuki H et al. | Prognostic factors of chronic rhinosinusitis under long-term low-dose macrolide therapy. | 2000 May-Jun | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:10810255 |
Luo Q et al. | Evaluation of long-term clarithromycin treatment in adult Chinese Patients with chronic rhinosinusitis without nasal polyps. | 2011 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:21757966 |
Mazis GA et al. | Recurrent fluctuant mass of the wrist and forearm associated with chronic tenosynovitis by Mycobacterium kansasii. | 2011 | Orthopedics | pmid:21598885 |
Buzás GM and Józan J | [Eradication of Helicobacter pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2002]. | 2004 | Orv Hetil | pmid:15559530 |
Prónai L and Tulassay Z | [Failure of Helicobacter pylori eradication--suggestions for further therapy]. | 2003 | Orv Hetil | pmid:12894674 |
Buzás GM | [Helicobacter pylori -- 2010]. | 2010 | Orv Hetil | pmid:21106480 |
Buzás GM et al. | [The epidemiology of clarithromycin resistance of Helicobacter pylori infection in Hungary]. | 2007 | Orv Hetil | pmid:17656336 |
Herszényi L | [Eradication of Helicobacter pylori]. | 2003 | Orv Hetil | pmid:14626641 |
Szántó D et al. | [Could Helicobacter pylori cause reactive arthro-osteitis?]. | 1997 | Orv Hetil | pmid:9340585 |
Hagymási K and Tulassay Z | [The new aspects of the eradication of Helicobacter pylori and the importance of bacterial resistance]. | 2008 | Orv Hetil | pmid:18926961 |
Buzás GM | [Helicobacter pylori - 2012]. | 2012 | Orv Hetil | pmid:22951408 |
Buzás György M et al. | [Lansoprazole versus ranitidine bismuth citrate containing triple regimens for Helicobacter pylori eradication in patients with duodenal ulcer]. | 2000 | Orv Hetil | pmid:10976194 |
Buzás GM | [The effect of Helicobacter pylori eradication on prokinetic treatment on the quality of life in functional dyspepsia]. | 2004 | Orv Hetil | pmid:15566071 |
Lengyel G and Zsolt T | [Failure in the eradication of Helicobacter pylori: the role of antibiotic resistance]. | 2005 | Orv Hetil | pmid:15926629 |
Bózsik BP | [Comment on Borrelia burgdorferi Group infections]. | 2002 | Orv Hetil | pmid:12073543 |
Cervin A et al. | One-year low-dose erythromycin treatment of persistent chronic sinusitis after sinus surgery: clinical outcome and effects on mucociliary parameters and nasal nitric oxide. | 2002 | Otolaryngol Head Neck Surg | pmid:12075221 |
Fraser L et al. | Atypical mycobacterial infection of the head and neck in children: a 5-year retrospective review. | 2008 | Otolaryngol Head Neck Surg | pmid:18312877 |
Tatar EÇ et al. | Prevalence of biofilms and their response to medical treatment in chronic rhinosinusitis without polyps. | 2012 | Otolaryngol Head Neck Surg | pmid:22241786 |
Hassmann-Poznańska E et al. | [Efficacy of clarithromycin (Fromilid) in treatment of uncomplicated acute bacterial rhinosinusitis in children]. | 2003 | Otolaryngol Pol | pmid:15049183 |
Denys A | [Theoretical basis for the antibiotic therapy of the upper part of the respiratory system]. | 1997 | Otolaryngol Pol | pmid:9757681 |
Kubas G and Gospodarek T | [The use of clarithromycin and amoxycillin in pediatric acute otitis media]. | 1997 | Otolaryngol Pol | pmid:9757683 |
Hayashi Y et al. | Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia. | 1999 | Pacing Clin Electrophysiol | pmid:10234723 |