clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Romero-Gómez M et al. | Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. | 2003 | Aliment. Pharmacol. Ther. | pmid:14616169 |
Datta S et al. | Most Helicobacter pylori strains of Kolkata in India are resistant to metronidazole but susceptible to other drugs commonly used for eradication and ulcer therapy. | 2005 | Aliment. Pharmacol. Ther. | pmid:15963080 |
Kamada T et al. | The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis. | 2003 | Aliment. Pharmacol. Ther. | pmid:12869086 |
Miehlke S et al. | Esomeprazole-based one-week triple therapy with clarithromycin and metronidazole is effective in eradicating Helicobacter pylori in the absence of antimicrobial resistance. | 2003 | Aliment. Pharmacol. Ther. | pmid:14535873 |
al-Assi MT et al. | Clarithromycin-amoxycillin therapy for Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:7986970 |
Gisbert JP et al. | Seven-day 'rescue' therapy after Helicobacter pylori treatment failure: omeprazole, bismuth, tetracycline and metronidazole vs. ranitidine bismuth citrate, tetracycline and metronidazole. | 1999 | Aliment. Pharmacol. Ther. | pmid:10540045 |
Ford AC et al. | Clinical trial: knowledge of negative Helicobacter pylori status reduces subsequent dyspepsia-related resource use. | 2007 | Aliment. Pharmacol. Ther. | pmid:17944741 |
Pilotto A and Malfertheiner P | Review article: an approach to Helicobacter pylori infection in the elderly. | 2002 | Aliment. Pharmacol. Ther. | pmid:11929385 |
Wong WM et al. | Lansoprazole, levofloxacin and amoxicillin triple therapy vs. quadruple therapy as second-line treatment of resistant Helicobacter pylori infection. | 2006 | Aliment. Pharmacol. Ther. | pmid:16423001 |
Savarino V et al. | The impact of antibiotic resistance on the efficacy of three 7-day regimens against Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:10886045 |
Smibert OC et al. | Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy. | 2017 | AIDS Res. Hum. Retroviruses | pmid:28791872 |
Chu J et al. | Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV. | 2011 | AIDS Res Ther | pmid:21388558 |
Aboulafia DM | Thalidomide-based treatment for HIV-associated multiple myeloma: a case report. | 2003 | AIDS Read | pmid:14524324 |
Kahlon SS et al. | Mycobacterium-avium-intracellulare complex immune reconstitution inflammatory syndrome in HIV/AIDS presenting as osteomyelitis. | 2008 | AIDS Read | pmid:18975441 |
Rosales CM et al. | AIDS presenting with cutaneous Kaposi's sarcoma and bacillary angiomatosis in the bone marrow mimicking Kaposi's sarcoma. | 2002 | AIDS Patient Care STDS | pmid:12542930 |
Mah Ming JB and Gill MJ | Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV. | 2003 | AIDS Patient Care STDS | pmid:12816614 |
Monno R et al. | Chlamydia trachomatis and Mycobacterium tuberculosis lung infection in an HIV-positive homosexual man. | 2001 | AIDS Patient Care STDS | pmid:11788074 |
Yangco BG et al. | Is primary mycobacterium avium complex prophylaxis necessary in patients with CD4 <50 cells/μL who are virologically suppressed on cART? | 2014 | AIDS Patient Care STDS | pmid:24833016 |
Desimone JA et al. | Treatment of Mycobacterium avium complex immune reconstitution disease in HIV-1-infected individuals. | 2003 | AIDS Patient Care STDS | pmid:14746655 |
NIAID study rules out high-dose clarithromycin for AIDS-related MAC. | 1996 | AIDS Patient Care STDS | pmid:11361534 | |
New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. | 1996 | AIDS Patient Care STDS | pmid:11361575 | |
Clarithromycin and MAC. | 1996 | AIDS Patient Care STDS | pmid:11361673 | |
Different clarithromycin doses affect mortality. | 1997 | AIDS Patient Care STDS | pmid:11361754 | |
Clarithromycin for MAC. | 1995 | AIDS Patient Care | pmid:11361361 | |
High-dose clarithromycin should be avoided. | 1996 | AIDS Alert | pmid:11363723 | |
Physician's aggressive preventive therapy differs. | 1995 | AIDS Alert | pmid:11362774 | |
New drug applications sought. | 1995 | AIDS Alert | pmid:11362777 | |
Researchers find new drugs to fight MAC. | 1995 | AIDS Alert | pmid:11362925 | |
Ives DV et al. | Impact of clarithromycin and azithromycin on patterns of treatment and survival among AIDS patients with disseminated Mycobacterium avium complex. | 1995 | AIDS | pmid:7755914 |
Fichtenbaum CJ et al. | Reply to 'Possible bias of ascertainment in assessing chemoprophylaxis for cryptosporidiosis' by Holmberg and Moorman. | 2001 | AIDS | pmid:11546956 |
Holmberg SD and Moorman AC | Possible bias of ascertainment in assessing chemoprophylaxis for cryptosporidiosis. | 2001 | AIDS | pmid:11504998 |
Chaisson RE et al. | Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. | 1997 | AIDS | pmid:9147422 |
Johnson RC et al. | Disseminated Mycobacterium ulcerans disease in an HIV-positive patient: a case study. | 2002 | AIDS | pmid:12172103 |
Heald AE et al. | Taste and smell complaints in HIV-infected patients. | 1998 | AIDS | pmid:9764787 |
MacÃas J et al. | Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. | 1997 | AIDS | pmid:9030376 |
Hewitt RG et al. | Prevention of disseminated Mycobacterium avium complex infection with reduced dose clarithromycin in patients with advanced HIV disease. | 1999 | AIDS | pmid:10449290 |
Preston SL et al. | Drug interactions in HIV-positive patients initiated on protease inhibitor therapy. | 1998 | AIDS | pmid:9468380 |
Bayoumi AM and Redelmeier DA | Preventing Mycobacterium avium complex in patients who are using protease inhibitors: a cost-effectiveness analysis. | 1998 | AIDS | pmid:9727572 |
Burman WJ et al. | Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen. | 1998 | AIDS | pmid:9708410 |
Fichtenbaum CJ et al. | Rifabutin but not clarithromycin prevents cryptosporidiosis in persons with advanced HIV infection. | 2000 | AIDS | pmid:11153670 |
Aboderin OA et al. | Antibiotic resistance of Helicobacter pylori from patients in Ile-Ife, South-west, Nigeria. | 2007 | Afr Health Sci | pmid:18052867 |
Ndip RN et al. | In-vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. | 2007 | Afr Health Sci | pmid:21499488 |
Pereira LH and Sterodimas A | Autologous fat transplantation and delayed silicone implant insertion in a case of Mycobacterium avium breast infection. | 2010 | Aesthetic Plast Surg | pmid:19495858 |
Chang CH et al. | Non-Tuberculous Mycobacteria Infection Following Autologous Fat Grafting on the Face. | 2017 | Aesthet Surg J | pmid:29045552 |
Rodrigues AD and Wong SL | Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience. | 1997 | Adv. Pharmacol. | pmid:9342173 |
Zycinska K et al. | Antibiotic Treatment of Hospitalized Patients with Pneumonia Complicated by Clostridium Difficile Infection. | 2016 | Adv. Exp. Med. Biol. | pmid:27620311 |
Siekmeier R et al. | Inhalation of macrolides: a novel approach to treatment of pulmonary infections. | 2015 | Adv. Exp. Med. Biol. | pmid:25252902 |
Radzikowska E et al. | Cryptogenic Organizing Pneumonia: IL-1β, IL-6, IL-8, and TGF- β1 Serum Concentrations and Response to Clarithromycin Treatment. | 2016 | Adv. Exp. Med. Biol. | pmid:26987326 |
Cheng KS et al. | Serum IL-8 as a possible marker for determining the status of Helicobacter pylori infection in patients with untreated and treated peptic ulcer. | 2004 Jan-Feb | Adv Ther | pmid:15191156 |
McCarty J et al. | Clarithromycin suspension vs penicillin V suspension in children with streptococcal pharyngitis. | 2000 Jan-Feb | Adv Ther | pmid:10915400 |
MacLeod CM et al. | Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa. | 2001 Mar-Apr | Adv Ther | pmid:11446271 |
Martinot JB et al. | A comparative study of clarithromycin modified release and amoxicillin/clavulanic acid in the treatment of acute exacerbation of chronic bronchitis. | 2001 Jan-Feb | Adv Ther | pmid:11512528 |
Sakurai Y et al. | Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study. | 2016 | Adv Ther | pmid:27432383 |
Nightingale CH | A survey of the quality of generic clarithromycin products manufactured in Slovenia and Israel. | 2000 May-Jun | Adv Ther | pmid:11183454 |
Suleymanlar I et al. | Response to triple treatment with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori infections in continuous ambulatory peritoneal dialysis patients. | 1999 | Adv Perit Dial | pmid:10682076 |
Blackington E | The gastric demon. An update on Helicobacter pylori infection. | 1999 | Adv Nurse Pract | pmid:10745720 |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
Iwańczak BM et al. | Assessment of Sequential and Standard Triple Therapy in Treatment of Helicobacter pylori Infection in Children Dependent on Bacteria Sensitivity to Antibiotics. | Adv Clin Exp Med | pmid:27629844 | |
Gościniak G et al. | Frequency of infection with Helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: A preliminary study. | Adv Clin Exp Med | pmid:28791844 | |
Radzikowska E et al. | Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. | Adv Clin Exp Med | pmid:28028949 | |
Cameselle D et al. | [Sporotrichoid cutaneous infection by Mycobacterium haemophilum in an AIDS patient]. | 2007 | Actas Dermosifiliogr | pmid:17504704 |
Gutiérrez-de la Peña J et al. | [Three cases of panniculitis due to Mycobacterium abscessus after mesotherapy]. | 2010 | Actas Dermosifiliogr | pmid:20223169 |
Baranowski WJ | Clarithromycin-induced hypomania in a child - a case report. | 2010 | Acta Psychiatr Scand | pmid:20491717 |
UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
Ozkan Y et al. | Clarithromycin targeting to lung: optimization of the size, morphology and release characteristics of albumin microspheres. | 2000 Sep-Oct | Acta Pol Pharm | pmid:11126029 |
Patel SS et al. | Formualtion and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. | 2006 Jan-Feb | Acta Pol Pharm | pmid:17515330 |
Luo X et al. | Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism. | 2009 | Acta Pharmacol. Sin. | pmid:19701237 |
Cao S et al. | Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy. | 2012 | Acta Pharmacol. Sin. | pmid:22820908 |
Qiao AM et al. | Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell. | 2006 | Acta Pharmacol. Sin. | pmid:17112418 |
Zhang L et al. | P-glycoprotein restricted transport of nimodipine across blood-brain barrier. | 2003 | Acta Pharmacol. Sin. | pmid:12956939 |
Cadranel S et al. | Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. | 2007 | Acta Paediatr. | pmid:17187610 |
de Jong J et al. | Antibiotic usage, dosage and course length in children between 0 and 4 years. | 2009 | Acta Paediatr. | pmid:19397542 |
Main KM et al. | Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient. | 2002 | Acta Paediatr. | pmid:12412882 |
Hurduc V et al. | A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. | 2009 | Acta Paediatr. | pmid:18681892 |
Hu YY et al. | Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000. | 2002 | Acta Paediatr. | pmid:11951998 |
Forslöw U et al. | Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | 2003 | Acta Paediatr. | pmid:12948065 |
Germanakis I et al. | Clarithromycin treatment and QT prolongation in childhood. | 2006 | Acta Paediatr. | pmid:17129988 |
Lerro P et al. | CagA seropositivity and the severity of Helicobacter pylori infection in dyspeptic children. | 2000 | Acta Paediatr. | pmid:11106041 |
Tirén U et al. | Helicobacter pylori gastritis in children: efficacy of 2 weeks of treatment with clarithromycin, amoxicillin and omeprazole. | 1999 | Acta Paediatr. | pmid:10102149 |
König C et al. | Legionella waltersii--a novel cause of pneumonia? | 2005 | Acta Paediatr. | pmid:16299887 |
Piédrola Maroto D et al. | [Present situation of antibiotic resistances in tonsillar infections]. | 2006 | Acta Otorrinolaringol Esp | pmid:16686226 |
Cantarella G et al. | Outcomes of structural fat grafting for paralytic and non-paralytic dysphonia. | 2011 | Acta Otorhinolaryngol Ital | pmid:22064781 |
Kozan G et al. | Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs. | 2015 | Acta Otolaryngol. | pmid:26143935 |
Iino Y et al. | Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media. | 2015 | Acta Otolaryngol. | pmid:25649881 |
Kondoh K et al. | Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa. | 1996 | Acta Otolaryngol Suppl | pmid:8908271 |
Rozynek E et al. | Primary resistance of Helicobacter pylori to antimicrobial agents in Polish children. | 2002 | Acta Microbiol. Pol. | pmid:12588100 |
Spengler G et al. | The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria. | 2004 | Acta Microbiol Immunol Hung | pmid:15571074 |
Kádár B et al. | In vitro activity of clarithromycin in combination with other antimicrobial agents against biofilm-forming Pseudomonas aeruginosa strains. | 2010 | Acta Microbiol Immunol Hung | pmid:20870595 |
Karpiński TM et al. | Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland. | 2015 | Acta Microbiol Immunol Hung | pmid:26551571 |
Koçkar C et al. | Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. | 2001 | Acta Medica (Hradec Kralove) | pmid:11811084 |
Hentschel E | [Treatment of Helicobacter pylori infections]. | 2000 | Acta Med. Austriaca | pmid:10989677 |
Rosário M et al. | [Profile of the resistance to macrolides and imidazoles of Helicobacter pylori in a sample of the Portuguese population]. | 1998 | Acta Med Port | pmid:10192979 |
Melo-Cristino J et al. | [Antimicrobial susceptibility of Streptococcus pyogenes, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis from community acquired respiratory infections in 2000]. | Acta Med Port | pmid:11878155 | |
Boal Carvalho P et al. | Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting? | 2017 | Acta Med Port | pmid:28550827 |
Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
Dabirmoghaddam P et al. | The efficacy of clarithromycin in patients with severe nasal polyposis. | 2013 | Acta Med Iran | pmid:23852839 |
Decazes JM | [What shall we make of the arrival of "generalized" antibiotics to anti-Hansen's therapy?]. | 2001-2002 | Acta Leprol | pmid:12136737 |
Mark TM and Coleman M | It's Time to Take Clarithromycin Seriously in Multiple Myeloma. | 2016 | Acta Haematol. | pmid:26505907 |
Qiu XH et al. | Clarithromycin Synergistically Enhances Thalidomide Cytotoxicity in Myeloma Cells. | 2016 | Acta Haematol. | pmid:26505646 |
Holmberg LA et al. | Results from Two Consecutive Studies of Consolidation Therapy after Autologous Transplant for Multiple Myeloma: Thalidomide, Dexamethasone, and Clarithromycin or Lenalidomide, Dexamethasone, and Clarithromycin. | 2017 | Acta Haematol. | pmid:28355602 |