| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Fractures, Open | D005597 | 3 associated lipids |
| Arthritis, Infectious | D001170 | 8 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hermon-Taylor J | Protagonist. Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease. | 2001 | Gut | pmid:11709506 |
| Treadway G and Reisman A | Tolerability of 3-day, once-daily azithromycin suspension versus standard treatments for community-acquired paediatric infectious diseases. | 2001 | Int. J. Antimicrob. Agents | pmid:11711256 |
| Gottrand F et al. | Omeprazole combined with amoxicillin and clarithromycin in the eradication of Helicobacter pylori in children with gastritis: A prospective randomized double-blind trial. | 2001 | J. Pediatr. | pmid:11713443 |
| Miwa H et al. | Clarithromycin resistance, but not CYP2C-19 polymorphism, has a major impact on treatment success in 7-day treatment regimen for cure of H. pylori infection: a multiple logistic regression analysis. | 2001 | Dig. Dis. Sci. | pmid:11713950 |
| Wang EJ et al. | Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11716514 |
| Björkholm B et al. | Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11717398 |
| Nagore E et al. | Cutaneous infection with Mycobacterium fortuitum after localized microinjections (mesotherapy) treated successfully with a triple drug regimen. | 2001 Aug-Sep | Acta Derm. Venereol. | pmid:11720180 |
| Choudhury L et al. | Torsades de pointes due to drug interaction between disopyramide and clarithromycin. | 1999 Sep-Oct | Heart Dis | pmid:11720625 |
| Nakamura S et al. | Duodenal mucosa-associated lymphoid tissue lymphoma treated by eradication of Helicobacter pylori: report of 2 cases including EUS findings. | 2001 | Gastrointest. Endosc. | pmid:11726860 |
| Ando R et al. | 3-(Arylacetylamino)-N-methylbenzamides: a novel class of selective anti-Helicobacter pylori agents. | 2001 | J. Med. Chem. | pmid:11728192 |
| Ausband SC and Goodman PE | An unusual case of clarithromycin associated ergotism. | 2001 | J Emerg Med | pmid:11728770 |
| Nakamura H et al. | [A case of Mycobacterium intracellulare infection complicated by immotile cilia syndrome]. | 2001 | Nihon Kokyuki Gakkai Zasshi | pmid:11729688 |
| Chandra NS et al. | Cluster of Mycobacterium chelonae keratitis cases following laser in-situ keratomileusis. | 2001 | Am. J. Ophthalmol. | pmid:11730644 |
| Solomon A et al. | Mycobacterium interface keratitis after laser in situ keratomileusis. | 2001 | Ophthalmology | pmid:11733259 |
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| Endo H et al. | Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin. | 2001 | J. Antimicrob. Chemother. | pmid:11733481 |
| Syrogiannopoulos GA et al. | High prevalence of erythromycin resistance of Streptococcus pyogenes in Greek children. | 2001 | Pediatr. Infect. Dis. J. | pmid:11734765 |
| Pea F and Furlanut M | Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions. | 2001 | Clin Pharmacokinet | pmid:11735605 |
| Goodgame RW et al. | Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn's disease. | 2001 | Aliment. Pharmacol. Ther. | pmid:11736715 |
| Wong BC et al. | Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection. | 2001 | Aliment. Pharmacol. Ther. | pmid:11736727 |
| Schiavano GF et al. | Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages. | 2001 | Int. J. Antimicrob. Agents | pmid:11738339 |
| Brook I et al. | In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones. | 2001 | Int. J. Antimicrob. Agents | pmid:11738344 |
| Lebel MH and Mehra S | Efficacy and safety of clarithromycin versus erythromycin for the treatment of pertussis: a prospective, randomized, single blind trial. | 2001 | Pediatr. Infect. Dis. J. | pmid:11740322 |
| Cascio A et al. | Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial. | 2002 | Clin. Infect. Dis. | pmid:11740701 |
| Tulassay Z et al. | One week of treatment with esomeprazole-based triple therapy eradicates Helicobacter pylori and heals patients with duodenal ulcer disease. | 2001 | Eur J Gastroenterol Hepatol | pmid:11742194 |
| Aberg JA et al. | Presence of macrolide resistance in respiratory flora of HIV-Infected patients receiving either clarithromycin or azithromycin for Mycobacterium avium complex prophylaxis. | 2001 Nov-Dec | HIV Clin Trials | pmid:11742432 |
| Mai AL and Mai KT | Fine-needle aspiration biopsy of an intra-abdominal inflammatory mass secondary to a penetrating duodenal ulcer mimicking neoplasm. | 2001 | Diagn. Cytopathol. | pmid:11747219 |
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| von Eiff C and Peters G | Comparative in vitro activity of ABT-773 and two macrolides against staphylococci. | 2002 | J. Antimicrob. Chemother. | pmid:11751787 |
| Katsura Y et al. | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. | 2002 | J. Med. Chem. | pmid:11754586 |
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| Gotfried MH | Epidemiology of clinically diagnosed community-acquired pneumonia in the primary care setting: results from the 1999-2000 respiratory surveillance program. | 2001 | Am. J. Med. | pmid:11755440 |
| Alpen B et al. | Helicobacter pylori eradication therapy in gastric high grade non Hodgkin's lymphoma (NHL). | 2001 | Ann. Hematol. | pmid:11757689 |
| Terry S et al. | Mycobacterium chelonae: nonhealing leg ulcers treated successfully with an oral antibiotic. | 2001 Nov-Dec | J Am Board Fam Pract | pmid:11757889 |
| Sasaki M et al. | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro. | 2001 | Mediators Inflamm. | pmid:11759110 |
| Pedrazzoli J et al. | Transfer of clarithromycin to gastric juice is enhanced by omeprazole in Helicobacter pylori-infected individuals. | 2001 | Scand. J. Gastroenterol. | pmid:11761012 |
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| Mégraud F | Resistance of Helicobacter pylori to antibiotics and its impact on treatment options. | 2001 | Drug Resist. Updat. | pmid:11768331 |
| Zheng X et al. | [The resistance of Helicobacter pylori toward metronidazole and clarithromycin]. | 2001 | Zhonghua Yi Xue Za Zhi | pmid:11769712 |
| Spahn JD et al. | Clarithromycin potentiates glucocorticoid responsiveness in patients with asthma: results of a pilot study. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11770698 |
| Carswell CI and Goa KL | Rabeprazole: an update of its use in acid-related disorders. | 2001 | Drugs | pmid:11772142 |
| Pan ZJ et al. | Assessment of clarithromycin-resistant Helicobacter pylori among patients in Shanghai and Guangzhou, China, by primer-mismatch PCR. | 2002 | J. Clin. Microbiol. | pmid:11773126 |
| Meyer JM et al. | Risk factors for Helicobacter pylori resistance in the United States: the surveillance of H. pylori antimicrobial resistance partnership (SHARP) study, 1993-1999. | 2002 | Ann. Intern. Med. | pmid:11777360 |
| Morris TC et al. | Phase II trial of clarithromycin and pamidronate therapy in myeloma. | 2001 | Med. Oncol. | pmid:11778973 |
| McEwan JA et al. | A hoarse voice: atypical mycobacterial infection of the larynx. | 2001 | J Laryngol Otol | pmid:11779312 |
| Harris LM et al. | Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. | 2001 | J. Ind. Microbiol. Biotechnol. | pmid:11781808 |
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| Glupczynski Y et al. | European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori. | 2001 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:11783701 |
| Dojo M et al. | Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan. | 2001 | Dig Liver Dis | pmid:11785712 |
| De Francesco V et al. | Two new treatment regimens for Helicobacter pylori eradication: a randomised study. | 2001 | Dig Liver Dis | pmid:11785713 |
| Sakamoto M et al. | Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer. | 2001 | Chemotherapy | pmid:11786660 |
| Ebnöther M et al. | Severe bronchiolitis in acute Mycoplasma pneumoniae infection. | 2001 | Virchows Arch. | pmid:11787856 |
| Gaubitz M et al. | Cat scratch disease (bartonellosis) mimicking an SLE flare. | 2001 | Lupus | pmid:11787880 |
| Monno R et al. | Chlamydia trachomatis and Mycobacterium tuberculosis lung infection in an HIV-positive homosexual man. | 2001 | AIDS Patient Care STDS | pmid:11788074 |
| Perry CM et al. | Gatifloxacin: a review of its use in the management of bacterial infections. | 2002 | Drugs | pmid:11790160 |
| Kutlin A et al. | Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model. | 2002 | Antimicrob. Agents Chemother. | pmid:11796350 |
| Tomioka H et al. | Intramacrophage passage of Mycobacterium tuberculosis and M. avium complex alters the drug susceptibilities of the organisms as determined by intracellular susceptibility testing using macrophages and type II alveolar epithelial cells. | 2002 | Antimicrob. Agents Chemother. | pmid:11796367 |
| Segura F and Antón E | Clarithromycin for the treatment of Mediterranean spotted fever. | 2002 | Clin. Infect. Dis. | pmid:11797192 |
| Summaries for patients. Factors associated with Helicobacter pylori infections in the United States that are resistant to usual antibiotics. | 2002 | Ann. Intern. Med. | pmid:11797613 | |
| Vemulapalli RK et al. | Emergence of resistance to clarithromycin during treatment of disseminated cutaneous Mycobacterium chelonae infection: case report and literature review. | 2001 | J. Infect. | pmid:11798252 |
| Abouesh A et al. | Antimicrobial-induced mania (antibiomania): a review of spontaneous reports. | 2002 | J Clin Psychopharmacol | pmid:11799346 |
| Vcev A et al. | Amoxycillin, clarithromycin and either sucralfate or pantoprazole for eradication of Helicobacter pylori in duodenal ulcer (a randomized controlled trial). | 2001 | Wien. Klin. Wochenschr. | pmid:11802510 |
| Treiber G et al. | Clinical outcome and influencing factors of a new short-term quadruple therapy for Helicobacter pylori eradication: a randomized controlled trial (MACLOR study). | 2002 | Arch. Intern. Med. | pmid:11802748 |
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| Tateda K et al. | Potential of macrolide antibiotics to inhibit protein synthesis of Pseudomonas aeruginosa: suppression of virulence factors and stress response. | 2000 | J. Infect. Chemother. | pmid:11810524 |
| Kunishima H et al. | Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549. | 2000 | J. Infect. Chemother. | pmid:11810567 |
| Koçkar C et al. | Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. | 2001 | Acta Medica (Hradec Kralove) | pmid:11811084 |
| Wurzer H et al. | Duodenal ulcer healing rates in a one-year follow-up study with ranitidine bismuth citrate and antibiotics. | 2001 Nov-Dec | Hepatogastroenterology | pmid:11813591 |
| Allin D et al. | Comparison of once- and twice-daily clarithromycin in the treatment of adults with severe acute lower respiratory tract infections. | 2001 | Clin Ther | pmid:11813931 |
| Morikawa K et al. | Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. | 2002 | Int. J. Antimicrob. Agents | pmid:11814768 |
| Murakami K et al. | Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy. | 2002 | Int. J. Antimicrob. Agents | pmid:11814770 |
| Portier H et al. | Five day clarithromycin modified release versus 10 day penicillin V for group A streptococcal pharyngitis: a multi-centre, open-label, randomized study. | 2002 | J. Antimicrob. Chemother. | pmid:11815577 |
| pmid:11817788 | ||||
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| Darkes MJ and Plosker GL | Cefditoren pivoxil. | 2002 | Drugs | pmid:11817976 |
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| Wu JC and Sung JJ | Ulcer and gastritis. | 2002 | Endoscopy | pmid:11822005 |
| Kim YS et al. | Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation. | 2002 | J. Gastroenterol. | pmid:11824795 |
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| Shiraishi Y et al. | Surgery for Mycobacterium avium complex lung disease in the clarithromycin era. | 2002 | Eur J Cardiothorac Surg | pmid:11825742 |
| Kato S et al. | Antibiotic resistance of Helicobacter pylori strains in Japanese children. | 2002 | J. Clin. Microbiol. | pmid:11825987 |
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| Khashaba PY | Spectrofluorimetric analysis of certain macrolide antibiotics in bulk and pharmaceutical formulations. | 2002 | J Pharm Biomed Anal | pmid:11836056 |
| Jiménez-Pulido A et al. | Hallucinations with therapeutic doses of clarithromycin. | 2002 | Int J Clin Pharmacol Ther | pmid:11837378 |
| Gaylor AS and Reilly JC | Therapy with macrolides in patients with cystic fibrosis. | 2002 | Pharmacotherapy | pmid:11837560 |
| Sakurane M et al. | Therapeutic effects of antibacterial treatment for intractable skin diseases in Helicobacter pylori-positive Japanese patients. | 2002 | J. Dermatol. | pmid:11837570 |
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| Turnak MR et al. | Antimicrobial susceptibilities of clinical isolates of Haemophilus influenzae and Moraxella catarrhalis collected during 1999-2000 from 13 countries. | 2001 | Clin. Microbiol. Infect. | pmid:11843908 |
| Nagai K et al. | Activity of telithromycin against 26 quinolone-resistant pneumococci with known quinolone-resistance mechanisms. | 2001 | Clin. Microbiol. Infect. | pmid:11843916 |
| De Bruin ML et al. | Use of cisapride with contraindicated drugs in The Netherlands. | 2002 | Ann Pharmacother | pmid:11847959 |
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