clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Barrett Esophagus D001471 3 associated lipids
Giardiasis D005873 3 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Eye Infections, Bacterial D015818 3 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Empyema D004653 3 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Pleuropneumonia D011001 3 associated lipids
Pityriasis Rosea D017515 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Irie Y et al. Antibiotic MICs and short time-killing against Helicobacter pylori: therapeutic potential of kanamycin. 1997 J. Antimicrob. Chemother. pmid:9301989
Stone GG et al. PCR-RFLP typing of ureC from Helicobacter pylori isolated from gastric biopsies during a European multi-country clinical trial. 1997 J. Antimicrob. Chemother. pmid:9301991
López-Brea M et al. Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori clinical isolates from Spain. 1997 J. Antimicrob. Chemother. pmid:9301996
Versalovic J et al. Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. 1997 J. Antimicrob. Chemother. pmid:9301997
Hoffman JS Pharmacological therapy of Helicobacter pylori infection. 1997 Semin. Gastrointest. Dis. pmid:9232728
Sano M et al. [A clinical study on combination therapy of antimicrobial agents for complicated urinary tract infection--with special reference to combination with clarithromycin]. 1997 Nippon Hinyokika Gakkai Zasshi pmid:9234616
Saluja A et al. A surgical wound infection due to Mycobacterium chelonae successfully treated with clarithromycin. 1997 Dermatol Surg pmid:9236871
Gisbert JP et al. [One-week treatment with omeprazole, clarithromycin and amoxicillin: high efficacy in the eradication of Helicobacter pylori and cicatrization of duodenal ulcer]. 1997 Med Clin (Barc) pmid:9190436
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Rodvold KA et al. Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. 1997 Antimicrob. Agents Chemother. pmid:9174209
Katari SR et al. Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. 1997 Clin Transplant pmid:9193849
Waites K et al. In vitro activities of oral antimicrobial agents against penicillin-resistant Streptococcus pneumoniae: implications for outpatient treatment. 1997 South. Med. J. pmid:9191739
Hoogkamp-Korstanje JA et al. Multicentre in-vitro evaluation of the susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to ciprofloxacin, clarithromycin, co-amoxiclav and sparfloxacin. 1997 J. Antimicrob. Chemother. pmid:9096192
Fujii K et al. Multiple primary Mycobacterium avium infection of the skin. 1997 Int. J. Dermatol. pmid:9071619
Stone GG et al. PCR-RFLP typing of ureC from Helicobacter pylori isolated in Argentina from gastric biopsies before and after treatment with clarithromycin. 1997 Epidemiol. Infect. pmid:9129588
Spicer ST et al. The mechanism of cyclosporine toxicity induced by clarithromycin. 1997 Br J Clin Pharmacol pmid:9131953
Guillemet C et al. [Clarithromycin-digoxin: an unrecognized interaction in some patients]. 1997 Presse Med pmid:9137381
Rodrigues AD et al. Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. 1997 Drug Metab. Dispos. pmid:9152603
Garrison MW et al. Influence of pH on the antimicrobial activity of clarithromycin and 14-hydroxyclarithromycin against Haemophilus influenzae using an in vitro pharmacodynamic model. 1997 Diagn. Microbiol. Infect. Dis. pmid:9154410
Nightingale CH Pharmacokinetics and pharmacodynamics of newer macrolides. 1997 Pediatr. Infect. Dis. J. pmid:9109156
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Yanagihara K et al. Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. 1997 Am. J. Respir. Crit. Care Med. pmid:9001333
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Tonai A et al. [Clarithromycin suppression of DNA synthesis by rat nasal mucosal cells enhanced by endotoxin instillation]. 1997 Jpn J Antibiot pmid:9678983
Martin SJ et al. In vitro activity of clarithromycin alone and in combination with ciprofloxacin or levofloxacin against Legionella spp.: enhanced effect by the addition of the metabolite 14-hydroxy clarithromycin. 1997 Diagn. Microbiol. Infect. Dis. pmid:9401809
Sander P et al. The role of ribosomal RNAs in macrolide resistance. 1997 Mol. Microbiol. pmid:9402018
Brancato R et al. Mycobacterium chelonae keratitis after excimer laser photorefractive keratectomy. 1997 Arch. Ophthalmol. pmid:9338681
Jingu K et al. [A case of fluminant Mycoplasma pneumonia and bronchiolitis managed by artificial respiration]. 1997 Nippon Naika Gakkai Zasshi pmid:9340346
Szántó D et al. [Could Helicobacter pylori cause reactive arthro-osteitis?]. 1997 Orv Hetil pmid:9340585
Yamamoto M et al. [The clinical study of clarithromycin for pulmonary Mycobacterium avium-intracellulare complex infection]. 1997 Kekkaku pmid:9038009
Rodrigues AD and Wong SL Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience. 1997 Adv. Pharmacol. pmid:9342173
Hoppe JE and Tschirner T Comparison of Etest and agar dilution for testing the activity of three macrolides against Bordetella parapertussis. 1997 Diagn. Microbiol. Infect. Dis. pmid:9218920
Yasui N et al. Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients. 1997 Int Clin Psychopharmacol pmid:9347384
May T et al. Comparison of combination therapy regimens for treatment of human immunodeficiency virus-infected patients with disseminated bacteremia due to Mycobacterium avium. ANRS Trial 033 Curavium Group. Agence Nationale de Recherche sur le Sida. 1997 Clin. Infect. Dis. pmid:9314450
Dohil R et al. Effective 2-wk therapy for Helicobacter pylori disease in children. 1997 Am. J. Gastroenterol. pmid:9040199
Wright DH Regression of mucosa-associated lymphoid-tissue lymphoma after eradication of Helicobacter pylori. 1997 Lancet pmid:9314895
Lerang F et al. Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? 1997 Am. J. Gastroenterol. pmid:9040200
Picardeau M et al. Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia. 1997 J. Clin. Microbiol. pmid:9316897
Chey WD et al. Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. 1997 Am. J. Gastroenterol. pmid:9317068
Brown BA et al. Clarithromycin-associated digoxin toxicity in the elderly. 1997 Clin. Infect. Dis. pmid:8994761
de'Clari F Ciprofloxacin was the culprit--not itraconazole. 1997 Clin. Infect. Dis. pmid:8994764
Raasveld MH et al. Cat-scratch disease mimicking pancreatic malignancy: case report. 1997 Clin. Infect. Dis. pmid:8994767
Greco S et al. Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. 1997 Ann Pharmacother pmid:9416400
Sugihara J et al. [Efficacy of clarithromycin on chronic paranasal sinusitis--a comparison between children and adult]. 1997 Jpn J Antibiot pmid:9597431
Hamada K et al. [Evaluation of antineoplastic effect of CAM (clarithromycin) in a mouse model inoculated with lung cancer cells]. 1997 Jpn J Antibiot pmid:9597434
Kokubo Y et al. [Effects of clarithromycin on experimental pulmonary metastasis]. 1997 Jpn J Antibiot pmid:9597436
Sakamoto M et al. [Efficacy of clarithromycin on cancer cachexia in patients with primary non-small cell lung cancer]. 1997 Jpn J Antibiot pmid:9597437
Teramoto S et al. [Fluctuation in the cytokine m-RNA content in primary non-small cell lung cancer caused by clarithromycin (CAM) administration]. 1997 Jpn J Antibiot pmid:9597438
Mikasa K et al. [Effect of clarithromycin on prolonging the life expectancy of patients with primary lung cancer]. 1997 Jpn J Antibiot pmid:9597439
Takeda H et al. [Macrolide antibiotic actions on bacteria and cultured airway cells]. 1997 Jpn J Antibiot pmid:9597448
Mita Y et al. [Vitamin D3 induction of differentiation of HL-60 cells to monocyte- like cells and their aggregation--a dynamic culture method and clarithromycin]. 1997 Jpn J Antibiot pmid:9597462
McLaren A et al. The role of ranitidine bismuth citrate in significantly reducing the emergence of Helicobacter pylori strains resistant to antibiotics. 1997 Helicobacter pmid:9432317
Nilius AM et al. Variability in susceptibilities of Haemophilus influenzae to clarithromycin and azithromycin due to medium pH. 1997 J. Clin. Microbiol. pmid:9163435
Bardhan KD et al. Effects of smoking on cure of Helicobacter pylori infection and duodenal ulcer recurrence in patients treated with clarithromycin and omeprazole. 1997 Helicobacter pmid:9432318
Takimoto T et al. The efficacy and safety of one-week triple therapy with lansoprazole, clarithromycin, and metronidazole for the treatment of Helicobacter pylori infection in Japanese patients. 1997 Helicobacter pmid:9432334
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Pieramico O et al. Omeprazole-based dual and triple therapy for the treatment of Helicobacter pylori infection in peptic ulcer disease: a randomized trial. 1997 Helicobacter pmid:9432335
Pounder RE et al. Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing. 1997 Helicobacter pmid:9432341
Reisner BS et al. Electron microscopic analysis of Mycobacterium avium complex isolates exposed to ciprofloxacin, rifabutin, ethambutol and clarithromycin. 1997 Int. J. Tuberc. Lung Dis. pmid:9432376
Lerang F et al. Highly effective second-line anti-Helicobacter pylori therapy in patients with previously failed metronidazole-based therapy. 1997 Scand. J. Gastroenterol. pmid:9438318
Akiyama H et al. Biofilm formation of Staphylococcus aureus strains isolated from impetigo and furuncle: role of fibrinogen and fibrin. 1997 J. Dermatol. Sci. pmid:9438901
Bazzoli F and Pozzato P Therapy of H. pylori infection. 1997 J. Physiol. Pharmacol. pmid:9440054
Dixon JS et al. Ranitidine bismuth citrate plus clarithromycin for the eradication of H. pylori. 1997 J. Physiol. Pharmacol. pmid:9440055
Yatsunami J et al. Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. 1997 Res Exp Med (Berl) pmid:9440137
Boixeda de Miquel D [Efficacy of the triple therapy in the eradication of H. pylori in peptic ulcer]. 1997 Rev Esp Enferm Dig pmid:9494374
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Bordet AL et al. [Mycobacterium chelonae cutaneous infection: efficacy of prolonged treatment by clarithromycin]. 1997 Ann Dermatol Venereol pmid:9686059
Klein JO History of macrolide use in pediatrics. 1997 Pediatr. Infect. Dis. J. pmid:9109154
McCracken GH Microbiologic activity of the newer macrolide antibiotics. 1997 Pediatr. Infect. Dis. J. pmid:9109155
Tarlow MJ Macrolides in the management of streptococcal pharyngitis/tonsillitis. 1997 Pediatr. Infect. Dis. J. pmid:9109157
Lévy M et al. Endoscopic ultrasonography for the initial staging and follow-up in patients with low-grade gastric lymphoma of mucosa-associated lymphoid tissue treated medically. 1997 Gastrointest. Endosc. pmid:9351036
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Breuer T et al. Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea. 1997 Aliment. Pharmacol. Ther. pmid:9354204
Wurzer H et al. Short-course therapy with amoxycillin-clarithromycin triple therapy for 10 days (ACT-10) eradicates Helicobacter pylori and heals duodenal ulcer. ACT-10 Study Group. 1997 Aliment. Pharmacol. Ther. pmid:9354205
Harris A H. pylori eradication by LAC. 1997 Aliment. Pharmacol. Ther. pmid:9354216
Jablonowski H et al. Ancillary benefits of Mycobacterium avium-intracellulare complex prophylaxis with clarithromycin in HIV-infected patients. 1997 Drugs pmid:9358196
Grosset J and Ji B Prevention of the selection of clarithromycin-resistant Mycobacterium avium-intracellulare complex. 1997 Drugs pmid:9358197
Dubé MP et al. A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group. 1997 J. Infect. Dis. pmid:9359722
Uemura N et al. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. 1997 Cancer Epidemiol. Biomarkers Prev. pmid:9264278
Mor N and Esfandiari A Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages. 1997 Antimicrob. Agents Chemother. pmid:9303411
Savarino V et al. A new 1-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus two antibiotics. 1997 Aliment. Pharmacol. Ther. pmid:9305478
Polis MA et al. Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection. 1997 Antimicrob. Agents Chemother. pmid:9257746
Shibata K et al. Bactericidal effect of ecabet sodium on clarithromycin- and metronidazole-resistant clinical isolates of Helicobacter pylori. 1997 Jpn J Antibiot pmid:9258741
Kato A [Effect of erythromycin and clarithromycin on ion transport across dissected canine tracheal epithelium]. 1997 Nippon Jibiinkoka Gakkai Kaiho pmid:9103848
Fietta A et al. Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. 1997 J Chemother pmid:9106014
Srinivasan R and Minocha A Cure of Helicobacter pylori: a hidden curse? 1997 Am. J. Gastroenterol. pmid:9399784
Different clarithromycin doses affect mortality. 1997 AIDS Patient Care STDS pmid:11361754
Akaki T et al. [In vivo activities of benzoxazinorifamycin KRM-1648, clarithromycin, and levofloxacin, or combination of KRM-1648 with diclofenac sodium against Mycobacterium avium infection induced in mice]. 1997 Kekkaku pmid:9293712
Recker MW and Kier KL Potential interaction between clarithromycin and warfarin. 1997 Ann Pharmacother pmid:9296238
Laberge P and Martineau P Clarithromycin-induced digoxin intoxication. 1997 Ann Pharmacother pmid:9296239
Matsukura N [Two step therapy for education of Helicobacter pylori]. 1997 Nihon Shokakibyo Gakkai Zasshi pmid:9284449
Bardhan KD et al. Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer. 1997 Gut pmid:9301496
Tan WC et al. Helicobacter pylori eradication--comparison of three drug regimens and symptomatic assessment in duodenitis and antral gastritis. 1997 Int. J. Clin. Pract. pmid:9287260
Kobler E et al. [Effectiveness of short-term triple therapy for healing Helicobacter pylori infection in ulcer disease]. 1997 Schweiz Med Wochenschr Suppl pmid:9289833