clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Pamuk ON et al. | Are Turkish Helicobacter pylori strains gaining resistance against clarithromycin? | 2000 | Am. J. Gastroenterol. | pmid:10926000 |
Hammerschlag MR | Treatment of Chlamydia pneumoniae. | 2000 | Int. J. Antimicrob. Agents | pmid:10926449 |
Nagaya T et al. | A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. | 2000 | J. Clin. Invest. | pmid:10930442 |
Van Oijen AH et al. | Review article: treatment of Helicobacter pylori infection with ranitidine bismuth citrate- or proton pump inhibitor-based triple therapies. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930892 |
Hurenkamp GJ et al. | Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930901 |
Lai KC et al. | Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930902 |
Pilotto A et al. | Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930903 |
Kihira K et al. | Rabeprazole, amoxycillin and low- or high-dose clarithromycin for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930904 |
Kamada T et al. | Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930905 |
Savarino V et al. | OAM for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930908 |
Yamashita H et al. | When can complete regression of low-grade gastric lymphoma of mucosa-associated lymphoid tissue be predicted after helicobacter pylori eradication? | 2000 | Histopathology | pmid:10931236 |
Gücüyener K et al. | Methyl-prednisolone in neurologic complications of Mycoplasma pneumonia. | 2000 | Indian J Pediatr | pmid:10932970 |
Theron AJ et al. | Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro. | 2000 | J. Antimicrob. Chemother. | pmid:10933651 |
Kihara Y and Otsuki M | Interaction of gliclazide and rifampicin. | 2000 | Diabetes Care | pmid:10937528 |
Morlet-Barla N et al. | [Severe hypoglycemia and recurrence caused by disopyramide-clarithromycin interaction]. | 2000 Jul 8-15 | Presse Med | pmid:10938688 |
Narita N | "Multi-effect" macrolides. | 2000 | Intern. Med. | pmid:10939528 |
Shivkumar K | Images in cardiovascular medicine. Labile repolarization from "cell to bedside". | 2000 | Circulation | pmid:10942753 |
Kamochi H et al. | Clarithromycin associated with torsades de pointes. | 1999 | Jpn. Circ. J. | pmid:10943628 |
Daudén E et al. | Helicobacter pylori and idiopathic chronic urticaria. | 2000 | Int. J. Dermatol. | pmid:10944090 |
Sato K and Ebe T | [A study on the effect of combined chemotherapy on Mycobacterium avium complex pulmonary disease]. | 2000 | Kekkaku | pmid:10944891 |
Katz VL et al. | Mycobacterium chelonae sepsis associated with long-term use of an intravenous catheter for treatment of hyperemesis gravidarum. A case report. | 2000 | J Reprod Med | pmid:10948471 |
Mayhew BS et al. | An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation. | 2000 | Drug Metab. Dispos. | pmid:10950845 |
Boxenbaum H | Human in vivo competitive inhibition of P450 substrates: increased plasma concentrations as a function of hepatic extraction ratio and percent inhibition. | 1999 Sep-Dec | J Pharm Pharm Sci | pmid:10953254 |
Gomollón F et al. | [Cost-effectiveness analysis of 2 strategies of Helicobacter pylori eradication: results of a prospective and randomized study in primary care]. | 2000 | Med Clin (Barc) | pmid:10953829 |
Piqué JM | [Helicobacter pylori eradication in gastroduodenal ulcer: good, fine and not expensive]. | 2000 | Med Clin (Barc) | pmid:10953833 |
Fujiue Y et al. | [Results of antimicrobial susceptibilities of strains clinically isolated at 8 institutions in Hiroshima City to major oral antimicrobial drugs, mainly new quinolone drugs. Hiroshima Levofloxacin Susceptibility Surveillance Group]. | 2000 | Jpn J Antibiot | pmid:10955237 |
Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
Dupas JL et al. | [Acid suppression therapy is not required after one-week anti-Helicobacter pylori triple therapy for duodenal ulcer healing]. | 2000 Jun-Jul | Gastroenterol. Clin. Biol. | pmid:10962387 |
McCarty JM | Clarithromycin in the management of community-acquired pneumonia. | 2000 | Clin Ther | pmid:10963284 |
Scaglione F et al. | In vitro comparative dynamics of modified-release clarithromycin and of azithromycin. | 2000 Sep-Oct | Chemotherapy | pmid:10965100 |
Castellote J and Porta F | [Combination of ranitidine and bismuth citrate plus 2 antibiotics in the eradication of Helicobacter pylori]. | 2000 | Med Clin (Barc) | pmid:10965489 |
Ozkan Y et al. | Clarithromycin targeting to lung: characterization, size distribution and in vivo evaluation of the human serum albumin microspheres. | 2000 | Farmaco | pmid:10966162 |
Katsura Y et al. | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. | 2000 | J. Med. Chem. | pmid:10966750 |
Heep M et al. | Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy. | 2000 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10968325 |
Beyer G et al. | Impact of moxifloxacin versus clarithromycin on normal oropharyngeal microflora. | 2000 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10968328 |
Gisbert JP et al. | Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy. | 2000 | Aliment. Pharmacol. Ther. | pmid:10971230 |
Frevel M et al. | Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short-term regimens. | 2000 | Aliment. Pharmacol. Ther. | pmid:10971231 |
Colin AA | Eradication of mycobacterium abscessus in a chronically infected patient with cystic fibrosis. | 2000 | Pediatr. Pulmonol. | pmid:10973047 |
Cattoli G et al. | Helicobacter acinonychis eradication leading to the resolution of gastric lesions in tigers. | 2000 | Vet. Rec. | pmid:10975334 |
Scuderi G et al. | Helicobacter pylori: use of a stool antigen detection test and a six-day triple therapy. | 2000 Jan-Feb | Dig Liver Dis | pmid:10975761 |
Buzás György M et al. | [Lansoprazole versus ranitidine bismuth citrate containing triple regimens for Helicobacter pylori eradication in patients with duodenal ulcer]. | 2000 | Orv Hetil | pmid:10976194 |
Sohn YT et al. | Polymorphism of clarithromycin. | 2000 | Arch. Pharm. Res. | pmid:10976587 |
Bosne-David S et al. | Intrinsic resistance of Mycobacterium tuberculosis to clarithromycin is effectively reversed by subinhibitory concentrations of cell wall inhibitors. | 2000 | J. Antimicrob. Chemother. | pmid:10980165 |
Denis A et al. | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10987440 |
Komine M and Tamaki K | An open trial of oral macrolide treatment for psoriasis vulgaris. | 2000 | J. Dermatol. | pmid:10989574 |
Hentschel E | [Treatment of Helicobacter pylori infections]. | 2000 | Acta Med. Austriaca | pmid:10989677 |
Bermudez LE et al. | Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice. | 2000 | Antimicrob. Agents Chemother. | pmid:10991834 |
Ohtani H et al. | Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats. | 2000 | Antimicrob. Agents Chemother. | pmid:10991836 |
Rastogi N et al. | In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4. | 2000 | Antimicrob. Agents Chemother. | pmid:10991870 |
Cynamon MH et al. | Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model. | 2000 | Antimicrob. Agents Chemother. | pmid:10991883 |