clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

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What functions are associated with clarithromycin?


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What lipids are associated with clarithromycin?

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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Durodie J and Slocombe B A clarithromycin sensitivity survey. 1994 J. Antimicrob. Chemother. pmid:7829421
Sano M et al. [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]. 1994 Kansenshogaku Zasshi pmid:7829898
Dorrell L et al. Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS. 1994 J. Antimicrob. Chemother. pmid:7868416
Funke G et al. Development of resistance to macrolide antibiotics in an AIDS patient treated with clarithromycin for Campylobacter jejuni diarrhea. 1994 Eur. J. Clin. Microbiol. Infect. Dis. pmid:7805694
Bonnet E et al. Clarithromycin: a potent agent against infections due to Mycobacterium marinum. 1994 Clin. Infect. Dis. pmid:8038339
Lemmen SW et al. Bactericidal activity of clarithromycin and cefaclor against Streptococcus pneumoniae and Moraxella catarrhalis in healthy volunteers. 1994 J. Antimicrob. Chemother. pmid:8040139
Dautzenberg B et al. [Treatment with clarithromycin of 173 HIV+ patients with disseminated Mycobacterium avium intracellulare infection]. 1994 Rev Mal Respir pmid:8041990
al-Assi MT et al. Clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for Helicobacter pylori infection. 1994 Am. J. Gastroenterol. pmid:8053435
Guelar A et al. [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. 1994 Enferm. Infecc. Microbiol. Clin. pmid:8011719
Aspin MM et al. Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. 1994 J. Pediatr. pmid:8021763
Chaisson RE et al. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. 1994 Ann. Intern. Med. pmid:7978715
Goldberger M and Masur H Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. 1994 Ann. Intern. Med. pmid:7978725
al-Assi MT et al. Clarithromycin-amoxycillin therapy for Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986970
Neri M et al. Omeprazole, bismuth and clarithromycin in the sequential treatment of Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986974
Chan GP et al. Clinical trial of clarithromycin for lepromatous leprosy. 1994 Antimicrob. Agents Chemother. pmid:8203847
[Recent advances in macrolide antibiotics: focused on clarithromycin. Discussion]. 1994 Jpn J Antibiot pmid:7990251
Onyeji CO et al. Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages. 1994 Antimicrob. Agents Chemother. pmid:8203849
Bermudez LE et al. Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7695252
Mor N et al. Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. 1994 Antimicrob. Agents Chemother. pmid:7695255
Marco ML et al. [Rhodococcus equi pneumonia in patients with AIDS]. 1994 Arch. Bronconeumol. pmid:7827773
Antibiotic gets FDA nod for MAC treatment. 1994 Am J Nurs pmid:8304386
Ji B et al. Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model. 1994 Antimicrob. Agents Chemother. pmid:7872741
Skinner PS et al. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions. 1994 Antimicrob. Agents Chemother. pmid:7872747
Valero G et al. Activities of clarithromycin, ofloxacin, and clarithromycin plus ethambutol against Mycobacterium simiae in murine model of disseminated infection. 1994 Antimicrob. Agents Chemother. pmid:7872769
Yamada S et al. [A child with iritis due to Chlamydia pneumoniae infection]. 1994 Kansenshogaku Zasshi pmid:7876679
Wüst J and Hardegger U Penetration of clarithromycin into human saliva. 1993 Sep-Oct Chemotherapy pmid:8370320
Scaglione F et al. A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. 1993 Nov-Dec Chemotherapy pmid:8222870
Ohmori S et al. Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats. 1993 Mar-Apr Drug Metab. Dispos. pmid:8097709
Wallace RJ et al. Drug intolerance to high-dose clarithromycin among elderly patients. 1993 Mar-Apr Diagn. Microbiol. Infect. Dis. pmid:8477575
Adam D Clarithromycin 250 mg b.i.d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis. 1993 Jul-Aug Infection pmid:8225636
Coles SJ et al. A comparative study of clarithromycin and amoxycillin suspensions in the treatment of pediatric patients with acute otitis media. 1993 Jul-Aug Infection pmid:8225637
Miller CA Infections, resistant microbes, and older adults. 1993 Jan-Feb Geriatr Nurs pmid:8383085
Ritchie DJ et al. In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens. 1993 Jan-Feb Clin Ther pmid:8458040
Albani F et al. Clarithromycin-carbamazepine interaction: a case report. 1993 Jan-Feb Epilepsia pmid:8422851
Sader HS et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. 1993 Aug-Sep Diagn. Microbiol. Infect. Dis. pmid:8243035
Humphreys JE et al. A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. 1993 J. Antimicrob. Chemother. pmid:8226438
Hakkarinen WD Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482929
Akiyama H et al. Interaction of Staphylococcus aureus cells and silk threads in vitro and in mouse skin. 1993 J. Dermatol. Sci. pmid:8136322
Luger SW Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482930
Granier H et al. [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. 1993 Ann Med Interne (Paris) pmid:8141516
MacGowan AR et al. Synergy testing of macrolide combinations using the chequerboard technique. 1993 J. Antimicrob. Chemother. pmid:8144439
Klein JO Clarithromycin: where do we go from here? 1993 Pediatr. Infect. Dis. J. pmid:8295817
Hardy DJ Extent and spectrum of the antimicrobial activity of clarithromycin. 1993 Pediatr. Infect. Dis. J. pmid:8295818
Dubois J et al. Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. 1993 Ear Nose Throat J pmid:8313865
Nasu M [Helicobacter pylori infections]. 1993 Nippon Naika Gakkai Zasshi pmid:8315343
Klopman G et al. Anti-Mycobacterium avium activity of quinolones: in vitro activities. 1993 Antimicrob. Agents Chemother. pmid:8239587
Mazzei T et al. Chemistry and mode of action of macrolides. 1993 J. Antimicrob. Chemother. pmid:7683018
Lazard T et al. Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. 1993 Antimicrob. Agents Chemother. pmid:7684213
Emori M et al. Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. 1993 Antimicrob. Agents Chemother. pmid:7684214
Heifets L et al. Mycobacterium avium strains resistant to clarithromycin and azithromycin. 1993 Antimicrob. Agents Chemother. pmid:8031351