| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Abscess | D000038 | 13 associated lipids |
| Achlorhydria | D000126 | 1 associated lipids |
| Actinomycetales Infections | D000193 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (2)
- Clin. Infect. Dis. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (2)
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cheng KS et al. | Serum IL-8 as a possible marker for determining the status of Helicobacter pylori infection in patients with untreated and treated peptic ulcer. | 2004 Jan-Feb | Adv Ther | pmid:15191156 |
| Martinot JB et al. | A comparative study of clarithromycin modified release and amoxicillin/clavulanic acid in the treatment of acute exacerbation of chronic bronchitis. | 2001 Jan-Feb | Adv Ther | pmid:11512528 |
| Sakurai Y et al. | Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study. | 2016 | Adv Ther | pmid:27432383 |
| Nightingale CH | A survey of the quality of generic clarithromycin products manufactured in Slovenia and Israel. | 2000 May-Jun | Adv Ther | pmid:11183454 |
| Suleymanlar I et al. | Response to triple treatment with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori infections in continuous ambulatory peritoneal dialysis patients. | 1999 | Adv Perit Dial | pmid:10682076 |
| Blackington E | The gastric demon. An update on Helicobacter pylori infection. | 1999 | Adv Nurse Pract | pmid:10745720 |
| Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |
| Iwańczak BM et al. | Assessment of Sequential and Standard Triple Therapy in Treatment of Helicobacter pylori Infection in Children Dependent on Bacteria Sensitivity to Antibiotics. | Adv Clin Exp Med | pmid:27629844 | |
| Gościniak G et al. | Frequency of infection with Helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: A preliminary study. | Adv Clin Exp Med | pmid:28791844 | |
| Radzikowska E et al. | Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. | Adv Clin Exp Med | pmid:28028949 | |
| Cameselle D et al. | [Sporotrichoid cutaneous infection by Mycobacterium haemophilum in an AIDS patient]. | 2007 | Actas Dermosifiliogr | pmid:17504704 |
| Gutiérrez-de la Peña J et al. | [Three cases of panniculitis due to Mycobacterium abscessus after mesotherapy]. | 2010 | Actas Dermosifiliogr | pmid:20223169 |
| Baranowski WJ | Clarithromycin-induced hypomania in a child - a case report. | 2010 | Acta Psychiatr Scand | pmid:20491717 |
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| Ozkan Y et al. | Clarithromycin targeting to lung: optimization of the size, morphology and release characteristics of albumin microspheres. | 2000 Sep-Oct | Acta Pol Pharm | pmid:11126029 |
| Patel SS et al. | Formualtion and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. | 2006 Jan-Feb | Acta Pol Pharm | pmid:17515330 |
| Luo X et al. | Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism. | 2009 | Acta Pharmacol. Sin. | pmid:19701237 |
| Cao S et al. | Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy. | 2012 | Acta Pharmacol. Sin. | pmid:22820908 |
| Qiao AM et al. | Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell. | 2006 | Acta Pharmacol. Sin. | pmid:17112418 |
| Zhang L et al. | P-glycoprotein restricted transport of nimodipine across blood-brain barrier. | 2003 | Acta Pharmacol. Sin. | pmid:12956939 |
| Cadranel S et al. | Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. | 2007 | Acta Paediatr. | pmid:17187610 |
| de Jong J et al. | Antibiotic usage, dosage and course length in children between 0 and 4 years. | 2009 | Acta Paediatr. | pmid:19397542 |
| Main KM et al. | Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient. | 2002 | Acta Paediatr. | pmid:12412882 |
| Hurduc V et al. | A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. | 2009 | Acta Paediatr. | pmid:18681892 |
| Hu YY et al. | Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000. | 2002 | Acta Paediatr. | pmid:11951998 |
| Forslöw U et al. | Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | 2003 | Acta Paediatr. | pmid:12948065 |
| Germanakis I et al. | Clarithromycin treatment and QT prolongation in childhood. | 2006 | Acta Paediatr. | pmid:17129988 |
| Lerro P et al. | CagA seropositivity and the severity of Helicobacter pylori infection in dyspeptic children. | 2000 | Acta Paediatr. | pmid:11106041 |
| Tirén U et al. | Helicobacter pylori gastritis in children: efficacy of 2 weeks of treatment with clarithromycin, amoxicillin and omeprazole. | 1999 | Acta Paediatr. | pmid:10102149 |
| König C et al. | Legionella waltersii--a novel cause of pneumonia? | 2005 | Acta Paediatr. | pmid:16299887 |
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| Cantarella G et al. | Outcomes of structural fat grafting for paralytic and non-paralytic dysphonia. | 2011 | Acta Otorhinolaryngol Ital | pmid:22064781 |
| Kozan G et al. | Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs. | 2015 | Acta Otolaryngol. | pmid:26143935 |
| Iino Y et al. | Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media. | 2015 | Acta Otolaryngol. | pmid:25649881 |
| Kondoh K et al. | Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa. | 1996 | Acta Otolaryngol Suppl | pmid:8908271 |
| Rozynek E et al. | Primary resistance of Helicobacter pylori to antimicrobial agents in Polish children. | 2002 | Acta Microbiol. Pol. | pmid:12588100 |
| Spengler G et al. | The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria. | 2004 | Acta Microbiol Immunol Hung | pmid:15571074 |
| Kádár B et al. | In vitro activity of clarithromycin in combination with other antimicrobial agents against biofilm-forming Pseudomonas aeruginosa strains. | 2010 | Acta Microbiol Immunol Hung | pmid:20870595 |
| Karpiński TM et al. | Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland. | 2015 | Acta Microbiol Immunol Hung | pmid:26551571 |
| Koçkar C et al. | Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. | 2001 | Acta Medica (Hradec Kralove) | pmid:11811084 |
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| Boal Carvalho P et al. | Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting? | 2017 | Acta Med Port | pmid:28550827 |
| Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
| Dabirmoghaddam P et al. | The efficacy of clarithromycin in patients with severe nasal polyposis. | 2013 | Acta Med Iran | pmid:23852839 |
| Decazes JM | [What shall we make of the arrival of "generalized" antibiotics to anti-Hansen's therapy?]. | 2001-2002 | Acta Leprol | pmid:12136737 |
| Mark TM and Coleman M | It's Time to Take Clarithromycin Seriously in Multiple Myeloma. | 2016 | Acta Haematol. | pmid:26505907 |
| Qiu XH et al. | Clarithromycin Synergistically Enhances Thalidomide Cytotoxicity in Myeloma Cells. | 2016 | Acta Haematol. | pmid:26505646 |
| Holmberg LA et al. | Results from Two Consecutive Studies of Consolidation Therapy after Autologous Transplant for Multiple Myeloma: Thalidomide, Dexamethasone, and Clarithromycin or Lenalidomide, Dexamethasone, and Clarithromycin. | 2017 | Acta Haematol. | pmid:28355602 |