clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Chlamydial Pneumonia D061387 2 associated lipids
Sacroiliitis D058566 1 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Renal Insufficiency D051437 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Calhoun KH and Hokanson JA Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. 1993 Arch Fam Med pmid:8111512
Saint-Marc T et al. [Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases]. 1993 Presse Med pmid:8121903
Hakkarinen WD Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482929
Akiyama H et al. Interaction of Staphylococcus aureus cells and silk threads in vitro and in mouse skin. 1993 J. Dermatol. Sci. pmid:8136322
Luger SW Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482930
Granier H et al. [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. 1993 Ann Med Interne (Paris) pmid:8141516
Vaara M Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria. 1993 Antimicrob. Agents Chemother. pmid:8383945
Romand S et al. In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. 1993 Antimicrob. Agents Chemother. pmid:8285620
Schmidt T et al. Clarithromycin lacks bactericidal activity in cerebrospinal fluid in experimental pneumococcal meningitis. 1993 J. Antimicrob. Chemother. pmid:8288505
Dautzenberg B et al. Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. 1993 Arch. Intern. Med. pmid:8427539
Walker LL et al. Clarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin. 1993 Int. J. Lepr. Other Mycobact. Dis. pmid:8326182
Alder J et al. Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. 1993 Antimicrob. Agents Chemother. pmid:8328782
Mor N and Heifets L Inhibition of intracellular growth of Mycobacterium avium by one pulsed exposure of infected macrophages to clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8328792
Helm CJ et al. Comparison of topical antibiotics for treating Mycobacterium fortuitum keratitis in an animal model. 1993 Am. J. Ophthalmol. pmid:8250072
Green PA et al. Mycobacterium avium complex parotid lymphadenitis: successful therapy with clarithromycin and ethambutol. 1993 Pediatr. Infect. Dis. J. pmid:8346008
Clinical Perspectives on Clarithromycin in Pediatric Infections. Symposium proceedings. February 19-20, 1993. 1993 Pediatr. Infect. Dis. J. pmid:7905199
Foltzer MA et al. Bronchopulmonary bacillary angiomatosis. 1993 Chest pmid:8365330
Sedlmayr T et al. [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. 1993 Geburtshilfe Frauenheilkd pmid:8370491
Chien SM et al. Treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing clarithromycin with erythromycin. Canada-Sweden Clarithromycin-Pneumonia Study Group. 1993 Chest pmid:8449054
Ji B et al. Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. 1993 J. Infect. Dis. pmid:8257487
Scaglione F et al. The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxy clarithromycin. 1993 J. Antimicrob. Chemother. pmid:8262876
Guay DR and Craft JC Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. 1993 Pediatr. Infect. Dis. J. pmid:8295810
Hebert AA et al. Comparative safety and efficacy of clarithromycin and cefadroxil suspensions in the treatment of mild to moderate skin and skin structure infections in children. 1993 Pediatr. Infect. Dis. J. pmid:8295811
Watanabe Y et al. Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin. 1993 J. Antibiot. pmid:8501007
Pukander JS et al. Clarithromycin vs. amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. 1993 Pediatr. Infect. Dis. J. pmid:8295812
McCarty JM et al. Comparative safety and efficacy of clarithromycin and amoxicillin/clavulanate in the treatment of acute otitis media in children. 1993 Pediatr. Infect. Dis. J. pmid:8295813
Gooch WM et al. Clarithromycin and cefaclor suspensions in the treatment of acute otitis media in children. 1993 Pediatr. Infect. Dis. J. pmid:8295814
Roig J et al. Treatment of Legionnaires' disease. Current recommendations. 1993 Drugs pmid:7691508
Still JG et al. Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. 1993 Pediatr. Infect. Dis. J. pmid:8295815
Craft JC and Siepman N Overview of the safety profile of clarithromycin suspension in pediatric patients. 1993 Pediatr. Infect. Dis. J. pmid:8295816
Klein JO Clarithromycin: where do we go from here? 1993 Pediatr. Infect. Dis. J. pmid:8295817
Hardy DJ Extent and spectrum of the antimicrobial activity of clarithromycin. 1993 Pediatr. Infect. Dis. J. pmid:8295818
Dubois J et al. Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. 1993 Ear Nose Throat J pmid:8313865
Nasu M [Helicobacter pylori infections]. 1993 Nippon Naika Gakkai Zasshi pmid:8315343
Nakashio S et al. [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. 1993 Jpn J Antibiot pmid:8360978
Mor N and Heifets L MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. 1993 Antimicrob. Agents Chemother. pmid:8431006
Tomioka H et al. In vitro antimicrobial activity of benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex, determined by the radiometric method. 1993 Antimicrob. Agents Chemother. pmid:8431020
Chu SY et al. Effect of moderate or severe hepatic impairment on clarithromycin pharmacokinetics. 1993 J Clin Pharmacol pmid:8331208
Graham DY et al. Clarithromycin for the eradication of Helicobacter pylori. 1993 J. Clin. Gastroenterol. pmid:8331260
Esvant H et al. [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. 1993 Presse Med pmid:8337221
Lederer J et al. Clarithromycin treatment of posttraumatic Mycobacterium fortuitum wound infection. 1993 Pediatr. Infect. Dis. J. pmid:8414785
de Vega T et al. Clarithromycin-induced leukocytoclastic vasculitis. 1993 Eur. J. Clin. Microbiol. Infect. Dis. pmid:8404922
Chu S et al. Single- and multiple-dose pharmacokinetics of clarithromycin, a new macrolide antimicrobial. 1993 J Clin Pharmacol pmid:8408732
Barradell LB et al. Clarithromycin. A review of its pharmacological properties and therapeutic use in Mycobacterium avium-intracellulare complex infection in patients with acquired immune deficiency syndrome. 1993 Drugs pmid:7691518
Mazzei T et al. Chemistry and mode of action of macrolides. 1993 J. Antimicrob. Chemother. pmid:7683018
Lazard T et al. Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. 1993 Antimicrob. Agents Chemother. pmid:7684213
Emori M et al. Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. 1993 Antimicrob. Agents Chemother. pmid:7684214
Holdcroft C Two new macrolide antibiotics: clarithromycin and azithromycin. 1993 Nurse Pract pmid:8380492
Dempsey CL et al. Drug usage evaluation: clarithromycin as sequential therapy. 1993 Hosp Formul pmid:10130382
Goldstein EJ and Citron DM Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. 1993 Antimicrob. Agents Chemother. pmid:8390810