clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| DÃaz F et al. | [Cat-scratch disease. A report of 4 cases and a review of the literature]. | 1997 | Rev Clin Esp | pmid:9102668 |
| Matsuoka N et al. | Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. | 1996 | Clin. Exp. Immunol. | pmid:9099936 |
| Klapper SR et al. | Atypical mycobacterial infection of the orbit. | 1995 | Ophthalmology | pmid:9097803 |
| Hoogkamp-Korstanje JA et al. | Multicentre in-vitro evaluation of the susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to ciprofloxacin, clarithromycin, co-amoxiclav and sparfloxacin. | 1997 | J. Antimicrob. Chemother. | pmid:9096192 |
| Gui GP et al. | Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics. | 1997 | J. Antimicrob. Chemother. | pmid:9096189 |
| Driscoll MS and Tyring SK | Development of resistance to clarithromycin after treatment of cutaneous Mycobacterium chelonae infection. | 1997 | J. Am. Acad. Dermatol. | pmid:9091495 |
| Gotoh A et al. | Susceptibility of Helicobacter pylori isolates against agents commonly administered for eradication therapy and the efficacy of chemotherapy. | 1997 | Microbiol. Immunol. | pmid:9087962 |
| Konishi T and Nakao M | Antibiotic treatment in mice infected with Japanese Borrelia garinii: efficacy of ceftriaxone for eradicating the infection induced by Ixodes persulcatus tick bites. | 1997 | Microbiol. Immunol. | pmid:9087959 |
| al-Humayyd MS | Pharmacokinetic interactions between erythromycin, clarithromycin, roxithromycin and phenytoin in the rat. | 1997 Mar-Apr | Chemotherapy | pmid:9084915 |
| Reed PI and Johnston BJ | Treatment of Helicobacter pylori infection. | 1997 | Biomed. Pharmacother. | pmid:9084725 |
| Labenz J | [Helicobacter pylori eradication: finally clarity]. | 1996 | Leber Magen Darm | pmid:9082109 |
| Fujii K et al. | Multiple primary Mycobacterium avium infection of the skin. | 1997 | Int. J. Dermatol. | pmid:9071619 |
| Weiss I et al. | Serotyping and susceptibility to macrolides and other antimicrobial drugs of Streptococcus pyogenes isolated from patients with invasive diseases in southern Israel. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063669 |
| GarcÃa-de-Lomas J et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolated from pediatric carriers in Spain. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9063666 |
| Moayyedi P et al. | Patient factors that predict failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. | 1997 | J. Gastroenterol. | pmid:9058291 |
| Stone GG et al. | A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori. | 1997 | Antimicrob. Agents Chemother. | pmid:9056021 |
| Roche B et al. | Efficacy of combined clarithromycin and sparfloxacin therapy in a patient with discitis: due to Mycobacterium xenopi. | 1997 | Rev Rhum Engl Ed | pmid:9051864 |
| Erah PO et al. | The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection. | 1997 | J. Antimicrob. Chemother. | pmid:9044021 |
| Labenz J et al. | Efficacy and tolerability of a one-week triple therapy consisting of pantoprazole, clarithromycin and amoxycillin for cure of Helicobacter pylori infection in patients with duodenal ulcer. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042979 |
| Labenz J et al. | One-week low-dose triple therapy for Helicobacter pylori is sufficient for relief from symptoms and healing of duodenal ulcers. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042978 |
| Axon AT et al. | Ranitidine bismuth citrate and clarithromycin twice daily in the eradication of Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9042977 |
| Brady RC et al. | Facial sporotrichoid infection with Mycobacterium marinum. | 1997 | J. Pediatr. | pmid:9042142 |
| Lerang F et al. | Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance? | 1997 | Am. J. Gastroenterol. | pmid:9040200 |
| Dohil R et al. | Effective 2-wk therapy for Helicobacter pylori disease in children. | 1997 | Am. J. Gastroenterol. | pmid:9040199 |
| Dautzenberg B et al. | A randomized comparison of two clarithromycin doses for treatment of Mycobacterium avium complex infections. | 1997 Jan-Feb | Infection | pmid:9039532 |
| Kelleher P et al. | Uveitis associated with rifabutin and macrolide therapy for Mycobacterium avium intracellulare infection in AIDS patients. | 1996 | Genitourin Med | pmid:9038637 |
| Yamamoto M et al. | [The clinical study of clarithromycin for pulmonary Mycobacterium avium-intracellulare complex infection]. | 1997 | Kekkaku | pmid:9038009 |
| Engelhardt E et al. | [Postoperative infection with Mycobacterium chelonae]. | 1996 | Hautarzt | pmid:9036143 |
| Burucoa C et al. | Western blot monitoring of disseminated Nocardia nova infection treated with clarithromycin, imipenem, and surgical drainage. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9031879 |
| Alarcón T et al. | In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9031877 |
| MacÃas J et al. | Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. | 1997 | AIDS | pmid:9030376 |
| Wang XM et al. | [Time course of disappearance of Helicobacter pylori after topical therapy and new triple therapy]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9028149 |
| Flisch CW et al. | [A case of arthritis of the wrist caused by Mycobacterium marinum. Review of the literature]. | 1996 | Ann Chir Main Memb Super | pmid:9026056 |
| Berg-Candolfi M and Candolfi E | Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection. | 1996 | Int. J. Parasitol. | pmid:9024879 |
| Paar D et al. | Life-threatening interaction between clarithromycin and disopyramide. | 1997 | Lancet | pmid:9024381 |
| Knothe H | [Short-term therapy of acute respiratory and ORL infections with Clarithromycin]. | 1992 | Z Gesamte Inn Med | pmid:9022402 |
| Banerjee DK et al. | Experimental evaluation of possible new short-term drug regimens for treatment of multibacillary leprosy. | 1997 | Antimicrob. Agents Chemother. | pmid:9021187 |
| Walzer PD et al. | Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. | 1997 | Antimicrob. Agents Chemother. | pmid:9021174 |
| Phull PS et al. | Lansoprazole plus clarithromycin: evaluation of a new dual therapy for Helicobacter pylori eradication. | 1996 Oct-Nov | Br J Clin Pract | pmid:9015906 |
| Drouet M et al. | [Unusual clinical form of amoxicillin allergy]. | 1996 | Allerg Immunol (Paris) | pmid:9011169 |
| Tursi A et al. | Evaluation of the efficacy and tolerability of four different therapeutic regimens for the Helicobacter pylori eradication. | 1996 | Panminerva Med | pmid:9009677 |
| Bock H and Mares A | [Good results with Helicobacter pylori eradication for treatment of non-ulcer dyspepsia]. | 1996 | Leber Magen Darm | pmid:9005302 |
| Shortridge VD et al. | Molecular typing of Helicobacter pylori isolates from a multicenter U.S. clinical trial by ureC restriction fragment length polymorphism. | 1997 | J. Clin. Microbiol. | pmid:9003618 |
| Gan VN et al. | Penetration of clarithromycin into middle ear fluid of children with acute otitis media. | 1997 | Pediatr. Infect. Dis. J. | pmid:9002099 |
| Yanagihara K et al. | Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9001333 |
| Tanaka E | [Pilot studies on the treatment of Mycobacterium avium complex lung disease--new macrolides and new quinolones. (2) Multi-drug chemotherapy for initial cases on trial]. | 1996 | Kekkaku | pmid:8999140 |
| Sakatani M | [Pilot studies on the treatment of Mycobacterium avium complex lung disease--new macrolides and new quinolones. (1) Continuous positive cases (failure of the initial chemotherapy)]. | 1996 | Kekkaku | pmid:8999139 |
| Tsuyuguchi K | [In vitro anti-MAC activities of new quinolones in focus (1)]. | 1996 | Kekkaku | pmid:8999136 |
| Tomioka H et al. | [Preclinical study of therapeutic agents used against Mycobacterium avium complex infections--with special reference to new macrolides and new quinolones]. | 1996 | Kekkaku | pmid:8999135 |
| van Zwet AA et al. | Prevalence of primary Helicobacter pylori resistance to metronidazole and clarithromycin in The Netherlands. | 1996 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8997557 |
| Drugs for treatment of peptic ulcers. | 1997 | Med Lett Drugs Ther | pmid:8996458 | |
| Taylor JL et al. | Pharmacoeconomic comparison of treatments for the eradication of Helicobacter pylori. | 1997 | Arch. Intern. Med. | pmid:8996045 |
| Torresin A et al. | Vinca alkaloids and macrolides in human immunodeficiency virus-related malignancies: a safe association. | 1996 | Cancer Chemother. Pharmacol. | pmid:8995518 |
| Raasveld MH et al. | Cat-scratch disease mimicking pancreatic malignancy: case report. | 1997 | Clin. Infect. Dis. | pmid:8994767 |
| de'Clari F | Ciprofloxacin was the culprit--not itraconazole. | 1997 | Clin. Infect. Dis. | pmid:8994764 |
| Brown BA et al. | Clarithromycin-associated digoxin toxicity in the elderly. | 1997 | Clin. Infect. Dis. | pmid:8994761 |
| Hachem CY et al. | Antimicrobial susceptibility testing of Helicobacter pylori. Comparison of E-test, broth microdilution, and disk diffusion for ampicillin, clarithromycin, and metronidazole. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:8988762 |
| Fischbach W et al. | Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:8988128 |
| Ono T et al. | In vitro and in vivo antibacterial activities of clarithromycin. | 1996 May-Jun | Chemotherapy | pmid:8983882 |
| MacFarlane JT et al. | Comparison of amoxycillin and clarithromycin as initial treatment of community-acquired lower respiratory tract infections. | 1996 | Br J Gen Pract | pmid:8983255 |
| Brenciaglia MI et al. | Inhibitory and bactericidal activity of rokitamycin against Helicobacter pylori and morphological alterations. | 1996 | J Chemother | pmid:8981182 |
| Adachi T et al. | Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL-5. | 1996 | J. Allergy Clin. Immunol. | pmid:8977529 |
| Pozniak A and Nelson MR | Against the proposition: all patients with advanced HIV disease should be offered rifabutin prophylaxis. | 1996 | Genitourin Med | pmid:8976832 |
| Iwata M et al. | [Bronchiolitis obliterans preceding rheumatoid arthritis: effect of clarithromycin]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8976086 |
| Naoki K et al. | [Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8976085 |
| Laine L et al. | Randomized comparison of differing periods of twice-a-day triple therapy for the eradication of Helicobacter pylori. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971306 |
| Pilotto A et al. | Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971305 |
| Moshkowitz M et al. | One week triple therapy with omeprazole, clarithromycin and tinidazole for Helicobacter pylori: differing efficacy in previously treated and untreated patients. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971304 |
| Harris AW et al. | Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971302 |
| Cammarota G et al. | Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971300 |
| Peeling RW and Brunham RC | Chlamydiae as pathogens: new species and new issues. | 1996 Oct-Dec | Emerging Infect. Dis. | pmid:8969247 |
| Grau E et al. | Interaction between clarithromycin and oral anticoagulants. | 1996 | Ann Pharmacother | pmid:8968465 |
| Labenz J | [Current developments in Helicobacter pylori therapy]. | 1996 | Leber Magen Darm | pmid:8965606 |
| Diemer PR et al. | [Rifabutin-induced hypopyon iritis in HIV infection]. | 1996 | Klin Monbl Augenheilkd | pmid:8965476 |
| Murakami K et al. | Atopic dermatitis successfully treated by eradication of Helicobacter pylori. | 1996 | J. Gastroenterol. | pmid:8959527 |
| Tonokatsu Y et al. | Eradication of Helicobacter pylori followed by reinfection. | 1996 | J. Gastroenterol. | pmid:8959526 |
| Shimoyama T et al. | Ecabet sodium eradicates Helicobacter pylori infection in gastric ulcer patients. | 1996 | J. Gastroenterol. | pmid:8959522 |
| Satoh K et al. | Efficacy of clarithromycin in eradicating Helicobacter pylori. | 1996 | J. Gastroenterol. | pmid:8959520 |
| Moreno JA et al. | Significant increase in eradication rates of Helicobacter pylori infection with two consecutive dual therapies (omeprazole and amoxycillin or omeprazole and clarithromycin). A randomized study in 450 Spanish patients. | 1996 | J. Gastroenterol. | pmid:8959519 |
| Griffith DE et al. | Varying dosages of rifabutin affect white blood cell and platelet counts in human immunodeficiency virus--negative patients who are receiving multidrug regimens for pulmonary Mycobacterium avium complex disease. | 1996 | Clin. Infect. Dis. | pmid:8953085 |
| Nagashima R et al. | Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori. | 1996 | Gastroenterology | pmid:8942749 |
| Bermudez LE et al. | Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model. | 1996 | J. Infect. Dis. | pmid:8940212 |
| Flamm RK et al. | Kill kinetics of antimicrobial agents against Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:8937967 |
| Koguchi M et al. | [Antimicrobial activities of clarithromycin against clinical isolates]. | 1996 | Jpn J Antibiot | pmid:8935125 |
| Yago K et al. | [Protein binding of clarithromycin in patients with chronic renal failure]. | 1996 | Jpn J Antibiot | pmid:8935121 |
| Vilmà nyi E et al. | Clarithromycin pharmacokinetics after oral administration with or without fasting in crossbred beagles. | 1996 | J Small Anim Pract | pmid:8934426 |
| Alder JD et al. | Relevance of the ferret model of Helicobacter-induced gastritis to evaluation of antibacterial therapies. | 1996 | Am. J. Gastroenterol. | pmid:8931416 |
| van der Hulst RW et al. | Therapeutic options after failed Helicobacter pylori eradication therapy. | 1996 | Am. J. Gastroenterol. | pmid:8931413 |
| Muñoz N et al. | Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study design and baseline data. | 1996 | IARC Sci. Publ. | pmid:8923024 |
| Aoyama T et al. | Efficacy of short-term treatment of pertussis with clarithromycin and azithromycin. | 1996 | J. Pediatr. | pmid:8917247 |
| Kuo CC et al. | In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8913488 |
| Koeck JL et al. | Disseminated Mycobacterium simiae infection in a patient with AIDS: clinical features and treatment. | 1996 | Clin. Infect. Dis. | pmid:8909856 |
| Kondoh K et al. | Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa. | 1996 | Acta Otolaryngol Suppl | pmid:8908271 |
| Pavlopoulou J et al. | Randomized controlled study of clarithromycin versus cefaclor suspensions in the treatment of acute otitis media in children. | 1995 | J Chemother | pmid:8904139 |
| Segreti J et al. | In vitro activity of macrolides against intracellular Legionella pneumophila. | 1996 | Diagn. Microbiol. Infect. Dis. | pmid:8902407 |
| Flurer CL | Analysis of macrolide antibiotics by capillary electrophoresis. | 1996 | Electrophoresis | pmid:8900943 |
| Schütze K et al. | Clarithromycin or amoxycillin plus high-dose ranitidine in the treatment of Helicobacter pylori-positive functional dyspepsia. | 1996 | Eur J Gastroenterol Hepatol | pmid:8900907 |
| Three new studies expand understanding of MAC therapy. | 1996 | Am J Health Syst Pharm | pmid:8899122 | |
| Spadaccini A et al. | Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers. | 1996 | Aliment. Pharmacol. Ther. | pmid:8899094 |
| Ghebremichael S et al. | Antimycobacterial synergism of clarithromycin and rifabutin. | 1996 | Scand. J. Infect. Dis. | pmid:8893404 |