clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yamamoto S et al. | Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998764 |
Wang EJ et al. | Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11716514 |
Yamanaka Y et al. | Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11549274 |
Sugita S et al. | EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25858318 |
Komatsu S et al. | Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23792097 |
Komori T et al. | Up-regulation by clarithromycin of alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes. | 2001 | Biochem. Pharmacol. | pmid:11709199 |
Burgie ES and Holden HM | Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine. | 2007 | Biochemistry | pmid:17630700 |
Sinan S et al. | Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro. | 2006 | Biochemistry Mosc. | pmid:16457617 |
Panozzo C et al. | Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. | 2017 | Biochim. Biophys. Acta | pmid:28888990 |
Mark T et al. | Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. | 2008 | Biol. Blood Marrow Transplant. | pmid:18541199 |
Kido H et al. | Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential. | 2004 | Biol. Chem. | pmid:15576322 |
Yoneda K et al. | In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. | 2009 | Biol. Pharm. Bull. | pmid:19336906 |
Matsui E et al. | The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice. | 2011 | Biol. Pharm. Bull. | pmid:21881230 |
Ishii K et al. | A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. | 1995 | Biol. Pharm. Bull. | pmid:7550125 |
Miyamoto D et al. | Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells. | 2008 | Biol. Pharm. Bull. | pmid:18239276 |
Togami K et al. | Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. | 2013 | Biol. Pharm. Bull. | pmid:23995662 |
Hanawa T et al. | In vitro antibacterial activity of Phx-3 against Helicobacter pylori. | 2010 | Biol. Pharm. Bull. | pmid:20118538 |
Komori T et al. | Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats. | 1998 | Biol. Pharm. Bull. | pmid:9881659 |
Masa K et al. | Effect of clarithromycin and other macrolides on the sulfoxidation and 5-hydroxylation of lansoprazole in dogs. | 1999 | Biol. Pharm. Bull. | pmid:10375172 |
Zaidi SF et al. | Potent bactericidal constituents from Mallotus philippinensis against clarithromycin and metronidazole resistant strains of Japanese and Pakistani Helicobacter pylori. | 2009 | Biol. Pharm. Bull. | pmid:19336896 |
Roccaro AM et al. | Advances in the treatment of monoclonal gammopaties: The emerging role of targeted therapy in plasma cell dyscrasias. | 2008 | Biologics | pmid:19707373 |
Prakash S and Urbanska AM | Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells. | 2008 | Biologics | pmid:19707368 |
Vijayananthan A et al. | Mastoiditis secondary to mycobacterium abscessus imaged with gallium-67 scintigraphy. | 2008 | Biomed Imaging Interv J | pmid:21614326 |
Liang CM et al. | Levofloxacin-containing second-line anti-Helicobacter pylori eradication in Taiwanese real-world practice. | Biomed J | pmid:25163495 | |
Peric A et al. | Influence of allergy on the immunomodulatory and clinical effects of long-term low-dose macrolide treatment of nasal polyposis. | 2010 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:21293544 |
Dogan Z et al. | The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24993741 |
Angol DC et al. | from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. | 2017 | Biomed Res Int | pmid:28555193 |
Nie W et al. | Species Identification and Clarithromycin Susceptibility Testing of 278 Clinical Nontuberculosis Mycobacteria Isolates. | 2015 | Biomed Res Int | pmid:26146620 |
Tai WC et al. | Seven-Day Nonbismuth Containing Quadruple Therapy Could Achieve a Grade "A" Success Rate for First-Line Helicobacter pylori Eradication. | 2015 | Biomed Res Int | pmid:26090428 |
Patel SK et al. | Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study. | 2014 | Biomed Res Int | pmid:25054141 |
Li W et al. | Liquid chromatographic-electrospray tandem mass spectrometric determination of clarithromycin in human plasma. | 2006 | Biomed. Chromatogr. | pmid:16838265 |
Niopas I and Daftsios AC | Determination of clarithromycin in human plasma by HPLC with electrochemical detection: validation and application in pharmacokinetic study. | 2001 | Biomed. Chromatogr. | pmid:11748684 |
Kousoulos C et al. | Validation of a fully automated high throughput liquid chromatographic/tandem mass spectrometric method for roxithromycin quantification in human plasma. Application to a bioequivalence study. | 2008 | Biomed. Chromatogr. | pmid:18059078 |
Reed PI and Johnston BJ | Treatment of Helicobacter pylori infection. | 1997 | Biomed. Pharmacother. | pmid:9084725 |
Espinal DA et al. | [Human metapneumovirus in children: first cases in Colombia]. | 2012 | Biomedica | pmid:23242289 |
Figueroa M et al. | [Antimicrobial susceptibility of Helicobacter pylori with chronic gastritis]. | 2012 Jan-Mar | Biomedica | pmid:23235785 |
Acosta CP et al. | [Determination of single nucleotide mutations in the 23S rRNA gene of Helicobacter pylori related to clarithromycin resistance in a population from Cauca, Colombia]. | 2014 | Biomedica | pmid:24968047 |
Kapić S et al. | Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity. | 2011 | Bioorg. Med. Chem. | pmid:22047805 |
Srivastav NC et al. | Studies on acyclic pyrimidines as inhibitors of mycobacteria. | 2007 | Bioorg. Med. Chem. | pmid:17218105 |
Shakya N et al. | Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22664188 |
Jia L and Sun H | Support vector machines classification of hERG liabilities based on atom types. | 2008 | Bioorg. Med. Chem. | pmid:18448342 |
Novak P et al. | Free and bound state structures of 6-O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes. | 2009 | Bioorg. Med. Chem. | pmid:19628398 |
Miroshnyk I et al. | A new insight into solid-state conformation of macrolide antibiotics. | 2008 | Bioorg. Med. Chem. | pmid:17936632 |
Miura T et al. | Novel 16-membered macrolides modified at C-12 and C-13 positions of midecamycin A1 and miokamycin. Part 1: Synthesis and evaluation of 12,13-carbamate and 12-arylalkylamino-13-hydroxy analogues. | 2008 | Bioorg. Med. Chem. | pmid:18258437 |
Heggelund A and Undheim K | Preparation of cyclic 2',3'-carbamate derivatives of erythromycin macrolide antibiotics. | 2007 | Bioorg. Med. Chem. | pmid:17337343 |
Kapić S et al. | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. | 2010 | Bioorg. Med. Chem. | pmid:20673633 |
Fajdetić A et al. | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. | 2010 | Bioorg. Med. Chem. | pmid:20634078 |
Hunziker D et al. | Novel ketolide antibiotics with a fused five-membered lactone ring--synthesis, physicochemical and antimicrobial properties. | 2004 | Bioorg. Med. Chem. | pmid:15186835 |
Allevi P et al. | A new convenient transformation of erythromycin A into clarithromycin. | 1999 | Bioorg. Med. Chem. | pmid:10658579 |
Miura T et al. | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. | 2010 | Bioorg. Med. Chem. | pmid:20236827 |
Anwar HF et al. | Synthesis of clarithromycin ketolides chemically modified at the unreactive C10-methyl group. | 2017 | Bioorg. Med. Chem. | pmid:28302508 |
Keserü GM | Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12873512 |
Xu P et al. | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19560350 |
Zhu D et al. | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. | 2013 | Bioorg. Med. Chem. Lett. | pmid:24139585 |
Kumar R et al. | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153939 |
Andreotti D et al. | A novel ketolide class: Synthesis and antibacterial activity of a lead compound. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17681467 |
Sherman D et al. | Synthesis and biological investigation of new 4''-malonyl tethered derivatives of erythromycin and clarithromycin. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16387493 |
Jia L et al. | Synthesis and antibacterial evaluation of novel 11-O-carbamoyl clarithromycin ketolides. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28711353 |
Waddell ST et al. | Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OME derivatives via clarithromycin. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871759 |
Yoshida Y et al. | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873455 |
Sakurai N et al. | Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873510 |
Jiang JW et al. | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23591116 |
Yoshida Y et al. | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560737 |
Nam G et al. | Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16275089 |
Hutinec A et al. | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462754 |
Liang JH et al. | Synthesis and antibacterial activities of a novel alkylide: 3-O-(3-aryl-2-propargyl) and 3-O-(3-aryl-2-propenyl)clarithromycin derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20356738 |
Ju Y et al. | Synthesis and antibacterial activity of novel 4''-O-arylalkylcarbamoyl and 4''-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462756 |
Epifano F et al. | In vitro inhibitory activity of boropinic acid against Helicobacter pylori. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16945527 |
Zhao Y et al. | A novel bicyclic ketolide derivative. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12729669 |
Denis A et al. | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10987440 |
Xu P et al. | Synthesis and antibacterial activity of 4''-O-heteroarylcarbamoyl derivatives of macrolide. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18815034 |
Lin X et al. | Synthesis and antibacterial activity of C12 des-methyl ketolides. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16784845 |
Liang JH et al. | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23375796 |
Srivastav NC et al. | Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22178557 |
Tobita M et al. | A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15911273 |
Lai CH et al. | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20705463 |
Xu P et al. | A new series of macrolide derivatives with 4''-O-saccharide substituents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20716487 |
Jakopović IP et al. | Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22503348 |
Hedaya MA et al. | The effect of ciprofloxacin and clarithromycin on sildenafil oral bioavailability in human volunteers. | 2006 | Biopharm Drug Dispos | pmid:16372380 |
Lee AK et al. | Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate. | 2004 | Biopharm Drug Dispos | pmid:15334627 |
Kanazu T et al. | Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats. | 2012 | Biopharm Drug Dispos | pmid:22447511 |
Lohitnavy O et al. | Average bioequivalence of generic clarithromycin tablets in healthy Thai male volunteers. | 2003 | Biopharm Drug Dispos | pmid:12973819 |
Ito S et al. | Effect of macrolide antibiotics on uptake of digoxin into rat liver. | 2007 | Biopharm Drug Dispos | pmid:17253595 |
Marsousi N et al. | Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software. | 2018 | Biopharm Drug Dispos | pmid:28960401 |
Arimori K et al. | Characteristic difference in gastrointestinal excretion of clarithromycin and roxithromycin. | 1998 | Biopharm Drug Dispos | pmid:9818709 |
Togami K et al. | Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages. | 2011 | Biopharm Drug Dispos | pmid:21812004 |
Zhu X et al. | Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. | 2007 | Biopharm Drug Dispos | pmid:17295362 |
Togami K et al. | Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin. | 2014 | Biopharm Drug Dispos | pmid:24801141 |
Hatters DM et al. | Sedimentation analysis of novel DNA structures formed by homo-oligonucleotides. | 2001 | Biophys. J. | pmid:11423421 |
RodrÃguez-RodrÃguez CE et al. | Solid-phase treatment with the fungus Trametes versicolor substantially reduces pharmaceutical concentrations and toxicity from sewage sludge. | 2011 | Bioresour. Technol. | pmid:21376580 |
Vaishnav P and Demain AL | Unexpected applications of secondary metabolites. | Biotechnol. Adv. | pmid:21130862 | |
Bugli F et al. | In vitro effect of clarithromycin and alginate lyase against helicobacter pylori biofilm. | 2016 | Biotechnol. Prog. | pmid:27535356 |
Nilsson MF and Webster WS | Effects of macrolide antibiotics on rat embryonic heart function in vitro. | 2014 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:24753334 |
Rossi A et al. | BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma. | 2013 | Blood | pmid:23299315 |
Stewart AK et al. | Lack of response to short-term use of clarithromycin (BIAXIN) in multiple myeloma. | 1999 | Blood | pmid:10391696 |
Niesvizky R et al. | BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma. | 2008 | Blood | pmid:17989313 |
Asaumi N et al. | Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. | 2004 | Blood Coagul. Fibrinolysis | pmid:15205594 |
Maiolino G et al. | Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. | 2018 | Blood Press. | pmid:29409357 |
Koratala A et al. | Exit Site Infection in Peritoneal Dialysis; Need for Follow-Up on Cultures Despite Clinical Improvement. | 2017 | Blood Purif. | pmid:28268216 |
Gao X et al. | Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells. | 2007 | BMC Cell Biol. | pmid:17524151 |