clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dabirmoghaddam P et al. | The efficacy of clarithromycin in patients with severe nasal polyposis. | 2013 | Acta Med Iran | pmid:23852839 |
Rosário M et al. | [Profile of the resistance to macrolides and imidazoles of Helicobacter pylori in a sample of the Portuguese population]. | 1998 | Acta Med Port | pmid:10192979 |
Melo-Cristino J et al. | [Antimicrobial susceptibility of Streptococcus pyogenes, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis from community acquired respiratory infections in 2000]. | Acta Med Port | pmid:11878155 | |
Boal Carvalho P et al. | Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting? | 2017 | Acta Med Port | pmid:28550827 |
Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
Hentschel E | [Treatment of Helicobacter pylori infections]. | 2000 | Acta Med. Austriaca | pmid:10989677 |
Koçkar C et al. | Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. | 2001 | Acta Medica (Hradec Kralove) | pmid:11811084 |
Spengler G et al. | The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria. | 2004 | Acta Microbiol Immunol Hung | pmid:15571074 |
Kádár B et al. | In vitro activity of clarithromycin in combination with other antimicrobial agents against biofilm-forming Pseudomonas aeruginosa strains. | 2010 | Acta Microbiol Immunol Hung | pmid:20870595 |
Karpiński TM et al. | Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland. | 2015 | Acta Microbiol Immunol Hung | pmid:26551571 |
Rozynek E et al. | Primary resistance of Helicobacter pylori to antimicrobial agents in Polish children. | 2002 | Acta Microbiol. Pol. | pmid:12588100 |
Kondoh K et al. | Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa. | 1996 | Acta Otolaryngol Suppl | pmid:8908271 |
Kozan G et al. | Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs. | 2015 | Acta Otolaryngol. | pmid:26143935 |
Iino Y et al. | Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media. | 2015 | Acta Otolaryngol. | pmid:25649881 |
Cantarella G et al. | Outcomes of structural fat grafting for paralytic and non-paralytic dysphonia. | 2011 | Acta Otorhinolaryngol Ital | pmid:22064781 |
Piédrola Maroto D et al. | [Present situation of antibiotic resistances in tonsillar infections]. | 2006 | Acta Otorrinolaringol Esp | pmid:16686226 |
Cadranel S et al. | Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. | 2007 | Acta Paediatr. | pmid:17187610 |
de Jong J et al. | Antibiotic usage, dosage and course length in children between 0 and 4 years. | 2009 | Acta Paediatr. | pmid:19397542 |
Lerro P et al. | CagA seropositivity and the severity of Helicobacter pylori infection in dyspeptic children. | 2000 | Acta Paediatr. | pmid:11106041 |
König C et al. | Legionella waltersii--a novel cause of pneumonia? | 2005 | Acta Paediatr. | pmid:16299887 |