clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Srivastava S et al. | Therapeutic drug management: is it the future of multidrug-resistant tuberculosis treatment? | 2013 | Eur. Respir. J. | pmid:24293417 |
[Clarithromycin therapy for patients with cystic fibrosis: a randomized controlled trial]. | 2013 | Jpn J Antibiot | pmid:24930240 | |
Sasaki H et al. | Ten-year trend of the cumulative Helicobacter pylori eradication rate for the 'Japanese eradication strategy'. | 2013 | Digestion | pmid:24356705 |
Yakoob J et al. | Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan. | 2013 | BMC Gastroenterol | pmid:23433429 |
Amin M et al. | Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants. | 2013 | Molecules | pmid:23434867 |
Kato H et al. | Addition of clarithromycin to lenalidomide/low-dose dexamethasone was effective in a case of relapsed myeloma after long-term use of lenalidomide. | 2013 | Ann. Hematol. | pmid:23625297 |
Bolhuis MS et al. | Clinical validation of the analysis of linezolid and clarithromycin in oral fluid of patients with multidrug-resistant tuberculosis. | 2013 | Antimicrob. Agents Chemother. | pmid:23689722 |
Togami K et al. | Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. | 2013 | Biol. Pharm. Bull. | pmid:23995662 |
Kim SG et al. | Helicobacter pylori eradication on iatrogenic ulcer by endoscopic resection of gastric tumour: a prospective, randomized, placebo-controlled multi-centre trial. | 2013 | Dig Liver Dis | pmid:23333104 |
Lim JH et al. | Clinical outcomes of two-week sequential and concomitant therapies for Helicobacter pylori eradication: a randomized pilot study. | 2013 | Helicobacter | pmid:23305083 |
Feng Z et al. | Dissociative disorder induced by clarithromycin combined with rabeprazole in a patient with gastritis. | 2013 | J. Int. Med. Res. | pmid:23569151 |
Gokmen T et al. | Clarithromycin treatment in preterm infants: a pilot study for prevention of feeding intolerance. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23570248 |
Faraji F et al. | The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. | 2012 Nov-Dec | Pain Physician | pmid:23159967 |
Eremenko AA et al. | [Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery]. | 2012 May-Jun | Anesteziol Reanimatol | pmid:22993930 |
Singh V et al. | Vesicular palmoplantar pityriasis rosea. | 2012 Mar-Apr | Skinmed | pmid:22545332 |
Gutiérrez-Castrellón P et al. | Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. | 2012 Mar-Apr | Rev. Invest. Clin. | pmid:22991774 |
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De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
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de Lalibera IB et al. | Meningoencephalitis associated with Mycoplasma pneumoniae. | 2012 Jan-Mar | Einstein (Sao Paulo) | pmid:23045836 |
Dhillon GS et al. | Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients. | 2012 Jan-Feb | Clin Transplant | pmid:21352378 |
Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
Montero-Tinnirello J et al. | [Pulmonary hemorrhage due to leptospirosis]. | 2012 Jan-Feb | Med Intensiva | pmid:21592620 |
Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
Matsushima M and Takagi A | "Is it effective?" to "How to use it?": the era has changed in probiotics and functional food products against Helicobacter pylori infection. | 2012 | J. Gastroenterol. Hepatol. | pmid:22515805 |
Fujita Y et al. | Pulmonary Actinomyces graevenitzii infection presenting as organizing pneumonia diagnosed by PCR analysis. | 2012 | J. Med. Microbiol. | pmid:22516132 |
Albaugh DR et al. | Time-dependent inhibition and estimation of CYP3A clinical pharmacokinetic drug-drug interactions using plated human cell systems. | 2012 | Drug Metab. Dispos. | pmid:22490230 |
Malfertheiner P et al. | Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. | 2012 | Gut | pmid:22491499 |
Huang YK et al. | Lansoprazole-based sequential and concomitant therapy for the first-line Helicobacter pylori eradication. | 2012 | J Dig Dis | pmid:22435509 |
Padovan J et al. | Investigating the barriers to bioavailability of macrolide antibiotics in the rat. | 2012 | Eur J Drug Metab Pharmacokinet | pmid:22113743 |
Walkey AJ and Wiener RS | Macrolide antibiotics and survival in patients with acute lung injury. | 2012 | Chest | pmid:22116799 |
Reva I et al. | Virulence genotypes and drug resistance of Helicobacter pylori from Vladivostok, Russia: another feature in the Far East. | 2012 | Microbiol. Immunol. | pmid:22211953 |
Park SJ et al. | Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection. | 2012 | Allergy Asthma Immunol Res | pmid:22211173 |
Falkinham JO et al. | Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria. | 2012 | Tuberculosis (Edinb) | pmid:22209468 |
Hutson JR et al. | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. | 2012 | Drugs Aging | pmid:22372724 |
Hegazy SK et al. | Effect of clarithromycin and fluconazole on the pharmacokinetics of montelukast in human volunteers. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22392555 |
Valizadeh H et al. | Antibacterial activity of clarithromycin loaded PLGA nanoparticles. | 2012 | Pharmazie | pmid:22393833 |
Togami K et al. | Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. | 2012 | J Aerosol Med Pulm Drug Deliv | pmid:22360316 |
Gisbert JP and Calvet X | Review article: rifabutin in the treatment of refractory Helicobacter pylori infection. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129228 |
Shiotani A et al. | H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands. | 2012 | J. Gastroenterol. | pmid:22382634 |
Nujić K et al. | Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities. | 2012 | Eur. J. Pharmacol. | pmid:22209877 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Kanazu T et al. | Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats. | 2012 | Biopharm Drug Dispos | pmid:22447511 |
Togami K et al. | Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. | 2012 | Pharmazie | pmid:22764569 |
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Inamo Y et al. | A 7-year-old girl with subcutaneous emphysema, pneumomediastinum, pneumothorax, and pneumoretroperitoneum caused by Mycoplasma pneumoniae pneumonia. | 2012 | J. Infect. Chemother. | pmid:21901497 |
Sezikli M et al. | Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori. | 2012 | J Clin Pharm Ther | pmid:21740452 |
Liang J et al. | Helicobacter pylori eradication with ecabet sodium, omeprazole, amoxicillin, and clarithromycin versus bismuth, omeprazole, amoxicillin, and clarithromycin quadruple therapy: a randomized, open-label, phase IV trial. | 2012 | Helicobacter | pmid:23066868 |
Erol E et al. | Antibiotic susceptibility patterns of Crossiella equi and Amycolatopsis species causing nocardioform placentitis in horses. | 2012 | J. Vet. Diagn. Invest. | pmid:23051830 |
Dalkmann P et al. | Accumulation of pharmaceuticals, Enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in central Mexico. | 2012 | PLoS ONE | pmid:23049795 |
Kurugol Z et al. | Severe Hemolytic Anemia Associated with Mild Pneumonia Caused by Mycoplasma pneumonia. | 2012 | Case Rep Med | pmid:23049568 |
Deng ZH et al. | Influence of Helicobacter pylori infection on ghrelin levels in children. | 2012 | World J. Gastroenterol. | pmid:23049220 |
Malfertheiner P et al. | Helicobacter pylori: clinical management. | 2012 | Curr. Opin. Gastroenterol. | pmid:23010682 |
Rimbara E et al. | Molecular epidemiologic analysis and antimicrobial resistance of Helicobacter cinaedi isolated from seven hospitals in Japan. | 2012 | J. Clin. Microbiol. | pmid:22593597 |
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Adrjanowicz K et al. | Molecular dynamics in supercooled liquid and glassy states of antibiotics: azithromycin, clarithromycin and roxithromycin studied by dielectric spectroscopy. Advantages given by the amorphous state. | 2012 | Mol. Pharm. | pmid:22540343 |
Lulitanond A et al. | Prevalence of β-lactamase-negative ampicillin-resistant haemophilus influenzae isolated from patients of a teaching hospital in Thailand. | 2012 | Jpn. J. Infect. Dis. | pmid:22446118 |
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Aoyama N et al. | Clarithromycin suppresses the periodontal bacteria-accelerated abdominal aortic aneurysms in mice. | 2012 | J. Periodont. Res. | pmid:22181324 |
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Carella AM et al. | Clarithromycin potentiates tyrosine kinase inhibitor treatment in patients with resistant chronic myeloid leukemia. | 2012 | Leuk. Lymphoma | pmid:22233113 |
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