clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Walkey AJ and Wiener RS | Macrolide antibiotics and survival in patients with acute lung injury. | 2012 | Chest | pmid:22116799 |
Park SJ et al. | Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection. | 2012 | Allergy Asthma Immunol Res | pmid:22211173 |
Falkinham JO et al. | Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria. | 2012 | Tuberculosis (Edinb) | pmid:22209468 |
Nseir W et al. | Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22646167 |
Zaater MF et al. | Determination and stability assessment of clarithromycin in human plasma using RP-LC with electrochemical detection. | 2012 | J Chromatogr Sci | pmid:22647394 |
Choi HS et al. | Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22654429 |
Majima Y et al. | Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp. | 2012 | Auris Nasus Larynx | pmid:21636230 |
Nujić K et al. | Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities. | 2012 | Eur. J. Pharmacol. | pmid:22209877 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Koh WJ et al. | Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22878282 |
Maurer FP et al. | Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41). | 2012 | J. Antimicrob. Chemother. | pmid:22833642 |
Togami K et al. | Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. | 2012 | Pharmazie | pmid:22764569 |
Fujioka T et al. | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan. | 2012 | J. Gastroenterol. | pmid:22065160 |
Park HG et al. | Randomised clinical trial: a comparative study of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori infection in naïve patients. | 2012 | Aliment. Pharmacol. Ther. | pmid:22066530 |
Chung JW et al. | Resistance of Helicobacter pylori strains to antibiotics in Korea with a focus on fluoroquinolone resistance. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793912 |
Erol E et al. | Antibiotic susceptibility patterns of Crossiella equi and Amycolatopsis species causing nocardioform placentitis in horses. | 2012 | J. Vet. Diagn. Invest. | pmid:23051830 |
Dalkmann P et al. | Accumulation of pharmaceuticals, Enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in central Mexico. | 2012 | PLoS ONE | pmid:23049795 |
Kurugol Z et al. | Severe Hemolytic Anemia Associated with Mild Pneumonia Caused by Mycoplasma pneumonia. | 2012 | Case Rep Med | pmid:23049568 |
Deng ZH et al. | Influence of Helicobacter pylori infection on ghrelin levels in children. | 2012 | World J. Gastroenterol. | pmid:23049220 |
Malfertheiner P et al. | Helicobacter pylori: clinical management. | 2012 | Curr. Opin. Gastroenterol. | pmid:23010682 |
Tepes B et al. | Treatment of Helicobacter pylori infection 2012. | 2012 | Helicobacter | pmid:22958154 |
Spyridaki A et al. | Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. | 2012 | Antimicrob. Agents Chemother. | pmid:22564837 |
Cajigas-Pezo D et al. | [Swelling of right knee in an immunologically compromised patient]. | 2012 | Enferm. Infecc. Microbiol. Clin. | pmid:22521279 |
McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2012 | Cochrane Database Syst Rev | pmid:23235681 |
Boyanova L et al. | Numerous risk factors for Helicobacter pylori antibiotic resistance revealed by extended anamnesis: a Bulgarian study. | 2012 | J. Med. Microbiol. | pmid:21873378 |
Yoon JH et al. | Trends in the eradication rates of Helicobacter pylori infection for eleven years. | 2012 | World J. Gastroenterol. | pmid:23236238 |
Kotsaki A and Giamarellos-Bourboulis EJ | Emerging drugs for the treatment of sepsis. | 2012 | Expert Opin Emerg Drugs | pmid:22780561 |
KurinÄiÄ M et al. | Epigallocatechin gallate as a modulator of Campylobacter resistance to macrolide antibiotics. | 2012 | Int. J. Antimicrob. Agents | pmid:22999765 |
Fiorini G et al. | Newer agents for Helicobacter pylori eradication. | 2012 | Clin Exp Gastroenterol | pmid:22767998 |
Whittemore KR and Cohen M | Imaging and review of a large pre-auricular pilomatrixoma in a child. | 2012 | World J Radiol | pmid:22761984 |
Kudo T et al. | Comparison of lafutidine and rabeprazole in 7-day second-line amoxicillin- and metronidazole-containing triple therapy for Helicobacter pylori: a pilot study. | 2012 | Helicobacter | pmid:22759327 |
Roccarina D et al. | Different Antibiotic No Culture Eradicating (DANCE) strategy: an easy way to manage H. pylori eradication. | 2012 | Dig Liver Dis | pmid:22743557 |
Tursi A et al. | Efficacy and tolerability of a third-line, levofloxacin-based, 10-day sequential therapy in curing resistant Helicobacter pylori infection. | 2012 | J Gastrointestin Liver Dis | pmid:22720300 |
Giguère S et al. | In vitro synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against Rhodococcus equi. | 2012 | Vet. Microbiol. | pmid:22704561 |
Burt HJ et al. | Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4. | 2012 | Drug Metab. Dispos. | pmid:22621802 |
Lismond A et al. | Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. | 2012 | Int. J. Antimicrob. Agents | pmid:22245497 |
Bermudez LE et al. | Identification of (+)-erythro-mefloquine as an active enantiomer with greater efficacy than mefloquine against Mycobacterium avium infection in mice. | 2012 | Antimicrob. Agents Chemother. | pmid:22615290 |
Agarwal E et al. | Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: a randomized controlled clinical trial. | 2012 | J. Periodontol. | pmid:22248223 |
Khan A et al. | Antibiotic resistance and cagA gene correlation: a looming crisis of Helicobacter pylori. | 2012 | World J. Gastroenterol. | pmid:22611319 |
Szałek E et al. | Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? | 2012 | Pharmacol Rep | pmid:23406766 |
Takeshima F et al. | Successful management of cap polyposis with eradication of Helicobacter pylori relapsing 15 years after remission on steroid therapy. | 2012 | Intern. Med. | pmid:22333383 |
Brereton AS and El Teraifi H | Mycobacterium malmoense: dissemination causes a popliteal aneurysm in a 74-year-old man. | 2012 | BMJ Case Rep | pmid:22602841 |
Lawal TO et al. | Combination studies of Eucalyptus torelliana F. Muell. leaf extracts and clarithromycin on Helicobacter pylori. | 2012 | Phytother Res | pmid:22318891 |
Slater CM and Ford AC | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305216 |
Gatta L et al. | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305217 |
Dicicco M et al. | Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius. | 2012 | BMC Vet. Res. | pmid:23171620 |
Graham DY and Trespalacios AA | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305218 |
Alfakry H et al. | The association of serum neutrophil markers and acute coronary syndrome. | 2012 | Scand. J. Immunol. | pmid:22537345 |
Shaifali I et al. | Antibiotic susceptibility patterns of urinary pathogens in female outpatients. | 2012 | N Am J Med Sci | pmid:22536558 |
Gisbert JP | Rescue Therapy for Helicobacter pylori Infection 2012. | 2012 | Gastroenterol Res Pract | pmid:22536225 |
Lee RP et al. | Mycobacterium chelonae infection after total knee arthroplasty: a case report. | 2012 | J Orthop Surg (Hong Kong) | pmid:22535831 |
Shaaban HS et al. | Mycobacterium chelonae infection of the parotid gland. | 2012 | J Glob Infect Dis | pmid:22529633 |
Fakheri H et al. | A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial. | 2012 | Helicobacter | pmid:22221615 |
Georgopoulos S et al. | Evaluation of a four-drug, three-antibiotic, nonbismuth-containing "concomitant" therapy as first-line Helicobacter pylori eradication regimen in Greece. | 2012 | Helicobacter | pmid:22221616 |
Senhorinho GN et al. | Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis. | 2012 | Anaerobe | pmid:22609780 |
Komatsu S et al. | Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. | 2012 | Int. J. Oncol. | pmid:22200786 |
Matsuzaki J et al. | Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies. | 2012 | Antimicrob. Agents Chemother. | pmid:22203601 |
Kobashi Y et al. | Relationship between clinical efficacy for pulmonary MAC and drug-sensitivity test for isolated MAC in a recent 6-year period. | 2012 | J. Infect. Chemother. | pmid:22205543 |
Lin Z and Will Y | Evaluation of drugs with specific organ toxicities in organ-specific cell lines. | 2012 | Toxicol. Sci. | pmid:22166485 |
Onoe H et al. | Buruli ulcer accompanied by pain in a Japanese patient. | 2012 | J. Dermatol. | pmid:22168180 |
Peters J et al. | Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin: results of a short-term drug interaction study in foals. | 2012 | Drug Metab. Dispos. | pmid:22170330 |
Lulitanond A et al. | Prevalence of β-lactamase-negative ampicillin-resistant haemophilus influenzae isolated from patients of a teaching hospital in Thailand. | 2012 | Jpn. J. Infect. Dis. | pmid:22446118 |
Liang Y et al. | Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children. | 2012 | J. Med. Microbiol. | pmid:22442290 |
Gomez-Abreo D et al. | [Chronic necrotizing pulmonary aspergillosis following an infection by Mycobacterium malmoense]. | 2012 | Rev Mal Respir | pmid:22440310 |
Guillot S et al. | Macrolide-resistant Bordetella pertussis infection in newborn girl, France. | 2012 | Emerging Infect. Dis. | pmid:22608348 |
Lee JH et al. | A nanohybrid system for taste masking of sildenafil. | 2012 | Int J Nanomedicine | pmid:22619517 |
Kongchayanun C et al. | Pilot studies to identify the optimum duration of concomitant Helicobacter pylori eradication therapy in Thailand. | 2012 | Helicobacter | pmid:22759328 |
Nguyen TV et al. | Eradication of Helicobacter pylori in children in Vietnam in relation to antibiotic resistance. | 2012 | Helicobacter | pmid:22759333 |
Hirata Y et al. | Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan. | 2012 | Int. J. Antimicrob. Agents | pmid:22321702 |
NiziÄ T et al. | Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. | 2012 | Wien. Klin. Wochenschr. | pmid:22760494 |
Yokota S et al. | Clarithromycin suppresses human respiratory syncytial virus infection-induced Streptococcus pneumoniae adhesion and cytokine production in a pulmonary epithelial cell line. | 2012 | Mediators Inflamm. | pmid:22761540 |
Brown-Elliott BA et al. | Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. | 2012 | Clin. Microbiol. Rev. | pmid:22763637 |
Pereyre S et al. | Clonal spread of Mycoplasma pneumoniae in primary school, Bordeaux, France. | 2012 | Emerging Infect. Dis. | pmid:22305177 |
Butler CC et al. | Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. | 2012 | BMJ | pmid:22302780 |
Carlos CA et al. | Mycobacterial infection identified with broad-range PCR amplification and suspension array identification. | 2012 | J. Cutan. Pathol. | pmid:22764735 |
Anand TD et al. | Superantigen profiles of emm and emm-like typeable and nontypeable pharyngeal streptococcal isolates of South India. | 2012 | Ann. Clin. Microbiol. Antimicrob. | pmid:22296671 |
Tonkic A et al. | Time trends of primary antibiotic resistance of Helicobacter pylori isolates in Southern Croatia. | 2012 | J Chemother | pmid:22759765 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
Yasar KK et al. | Successfully treated Mycobacterium abscessus mastitis: a rare cause of breast masses. | 2011 Oct-Dec | Indian J Med Microbiol | pmid:22120809 |
Eisig JN et al. | Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option. | 2011 Oct-Dec | Arq Gastroenterol | pmid:22147131 |
Abadi AT et al. | High frequency of A2143G mutation in clarithromycin-resistant Helicobacter pylori isolates recovered from dyspeptic patients in Iran. | 2011 Nov-Dec | Saudi J Gastroenterol | pmid:22064338 |
Bilgili SG et al. | Phototoxic dermatitis due to Chenopodium album in a child. | 2011 Nov-Dec | Pediatr Dermatol | pmid:21854411 |
Lee CY et al. | Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature. | 2011 Nov-Dec | Can J Cardiol | pmid:21907534 |
Zeng M et al. | Comparison of efficacy of mometasone furoate versus clarithromycin in the treatment of chronic rhinosinusitis without nasal polyps in Chinese adults. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185725 |
Mello CF and Negra MD | Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital. | 2011 May-Jun | Braz J Infect Dis | pmid:21670928 |
Schmidt D | [The choice of treatment in HP associated ulcer: metronidazole or amoxicillin--nothing else!]. | 2011 May 4-10 | Lakartidningen | pmid:21809531 |
Steyaert S et al. | Soft tissue infections with atypical mycobacteria in two patients with inflammatory rheumatic diseases using TNF-inhibitors and/or leflunomide. | 2011 Mar-Apr | Acta Clin Belg | pmid:21630616 |
Söderberg KC and Böttiger Y | [Difficult choice between clarithromycin and metronidazole in polyneuropathy]. | 2011 Mar 9-15 | Lakartidningen | pmid:21744557 |
Chung JW et al. | The trends of one-week first-line and second-line eradication therapy for Helicobacter pylori infection in Korea. | 2011 Jan-Feb | Hepatogastroenterology | pmid:21510323 |
Galmés-Truyols A et al. | An outbreak of cutaneous infection due to Mycobacterium abscessus associated to mesotherapy. | 2011 Aug-Sep | Enferm. Infecc. Microbiol. Clin. | pmid:21684045 |
Cisarò F et al. | Ranitidine bismuth citrate in the first-line of Helicobacter pylori treatment. | 2011 | Panminerva Med | pmid:21659979 |
Cardoso AM et al. | In Vitro Antimicrobial Susceptibility of Mycobacterium massiliense Recovered from Wound Samples of Patients Submitted to Arthroscopic and Laparoscopic Surgeries. | 2011 | Minim Invasive Surg | pmid:22110914 |
Girish C and Balakrishnan S | Ceftaroline fosamil: A novel anti-Methicillin-resistant Staphylococcus aureus cephalosporin. | 2011 | J Pharmacol Pharmacother | pmid:21897727 |
Iskandar I and Walters JD | Clarithromycin accumulation by phagocytes and its effect on killing of Aggregatibacter actinomycetemcomitans. | 2011 | J. Periodontol. | pmid:20932153 |
Karczewska E et al. | Primary and secondary clarithromycin, metronidazole, amoxicillin and levofloxacin resistance to Helicobacter pylori in southern Poland. | 2011 | Pharmacol Rep | pmid:21857091 |
Urgesi R et al. | Helicobacter pylori infection: is sequential therapy superior to standard triple therapy? A single-centre Italian study in treatment-naive and non-treatment-naive patients. | 2011 | Can. J. Gastroenterol. | pmid:21766091 |
File TM et al. | FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. | 2011 | J. Antimicrob. Chemother. | pmid:21482566 |
RodrÃguez-RodrÃguez CE et al. | Solid-phase treatment with the fungus Trametes versicolor substantially reduces pharmaceutical concentrations and toxicity from sewage sludge. | 2011 | Bioresour. Technol. | pmid:21376580 |
Andreassen TN et al. | Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients. | 2011 | Eur. J. Clin. Pharmacol. | pmid:21140139 |