clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 242

PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Piquette RK Torsade de pointes induced by cisapride/clarithromycin interaction. 1999 Ann Pharmacother pmid:9972380
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Desta Z et al. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). 1999 Clin. Pharmacol. Ther. pmid:9951426
Principi N and Esposito S Comparative tolerability of erythromycin and newer macrolide antibacterials in paediatric patients. 1999 Drug Saf pmid:9935275
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García-Arata MI et al. Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin. 1999 Antimicrob. Agents Chemother. pmid:9925537
Stefansson P et al. Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis. 1998 Rhinology pmid:9923060
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Fera MT et al. Bactericidal activity of lansoprazole and three macrolides against Helicobacter pylori strains tested by the time-kill kinetic method. 1998 Int. J. Antimicrob. Agents pmid:9916902
Lacy MK et al. Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and ceruroxime axetil against Streptococcus pneumoniae. 1998 Int. J. Antimicrob. Agents pmid:9916901
Abe M et al. A case of diffuse panbronchiolitis effectively treated with low-dose macrolide antibiotics and leukotriene D4/E4 receptor antagonist. 1998 Respir Med pmid:9893782
Savarino V et al. Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection. 1999 Aliment. Pharmacol. Ther. pmid:9892878
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Tohnai A et al. Clarithromycin suppresses proliferation of rat nasal epithelium exposed to endotoxin. 1998 Nov-Dec Am J Rhinol pmid:9883303
Martín Mir ML et al. [Effectiveness of the eradication of Helicobacter pylori by treatment with omeprazol, amoxicillin, and clarithromycin according to dosage and administration schedule]. 1998 Gastroenterol Hepatol pmid:9882932
Komori T et al. Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats. 1998 Biol. Pharm. Bull. pmid:9881659
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Komori T et al. Effect of clarithromycin on alpha1-acid glycoprotein levels in normal and diabetic rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9874281
Sakurai N et al. Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. 1998 Bioorg. Med. Chem. Lett. pmid:9873510
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Sakaki N et al. Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection. 1998 J. Clin. Gastroenterol. pmid:9872520
Suzuki J et al. Relationship between the eradication of Helicobacter pylori and the healing pattern of peptic ulcer. 1998 J. Clin. Gastroenterol. pmid:9872515
Lee CL et al. One-week low-dose triple therapy is effective in treating Helicobacter pylori-infected patients with bleeding peptic ulcers. 1998 J. Formos. Med. Assoc. pmid:9872028
Waddell ST et al. Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OME derivatives via clarithromycin. 1998 Bioorg. Med. Chem. Lett. pmid:9871759
van Westrhenen R et al. Pneumonia and glomerulonephritis caused by Mycoplasma pneumoniae. 1998 Nephrol. Dial. Transplant. pmid:9870493
Sassa K et al. Therapeutic effect of clarithromycin on a transplanted tumor in rats. 1999 Antimicrob. Agents Chemother. pmid:9869567
Shafran SD et al. Does in vitro susceptibility to rifabutin and ethambutol predict the response to treatment of Mycobacterium avium complex bacteremia with rifabutin, ethambutol, and clarithromycin? Canadian HIV Trials Network Protocol 010 Study Group. 1998 Clin. Infect. Dis. pmid:9868650
Wallace RJ and Brown BA Catheter sepsis due to Mycobacterium chelonae. 1998 J. Clin. Microbiol. pmid:9867491
Al-Sibai MB et al. Ocular penetration of oral clarithromycin in humans. 1998 J Ocul Pharmacol Ther pmid:9867340
Maeda S et al. Helicobacter pylori specific nested PCR assay for the detection of 23S rRNA mutation associated with clarithromycin resistance. 1998 Gut pmid:9863474
Blum AL et al. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. 1998 N. Engl. J. Med. pmid:9862942
Adelglass J et al. A multicenter, investigator-blinded, randomized comparison of oral levofloxacin and oral clarithromycin in the treatment of acute bacterial sinusitis. 1998 Nov-Dec Pharmacotherapy pmid:9855324
Shimoyama T et al. Healing of cimetidine-resistant Ménétrier's disease by eradication of Helicobacter pylori infection. 1998 J. Clin. Gastroenterol. pmid:9855268
Cadwgan AM et al. Neisseria meningitidis W135 pneumonia with sepicaemia in a nonogenarian. 1998 Scott Med J pmid:9854302
Coudron PE and Stratton CW In-vitro evaluation of nitrofurantoin as an alternative agent for metronidazole in combination antimicrobial therapy against Helicobacter pylori. 1998 J. Antimicrob. Chemother. pmid:9848452
Gudjonsson H et al. High Helicobacter pylori eradication rate with a 1-week regimen containing ranitidine bismuth citrate. 1998 Aliment. Pharmacol. Ther. pmid:9845401
Gisbert JP et al. [Role of pantoprazole in the eradicating treatment of Helicobacter pylori]. 1998 Rev Clin Esp pmid:9844458
Gisbert JP et al. [Omeprazole plus 2 antibiotics for the eradication of H. pylori, are 5 days of treatment sufficient?]. 1998 Rev Clin Esp pmid:9844453
Kato S et al. Safety and efficacy of one-week triple therapy for eradicating Helicobacter pylori in children. 1998 Helicobacter pmid:9844069
Ohkusa T et al. Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial. 1998 Ann. Intern. Med. pmid:9841603
Moayyedi P et al. Relevance of antibiotic sensitivities in predicting failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. 1998 J. Gastroenterol. pmid:9840021
Borody TJ et al. Eradication therapies for Helicobacter pylori. 1998 J. Gastroenterol. pmid:9840019
Hogan PA and Sheehan DJ Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997. 1998 Antimicrob. Agents Chemother. pmid:9835536
Berry V et al. Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. 1998 Antimicrob. Agents Chemother. pmid:9835514
Xia HH et al. Metronidazole- and clarithromycin-resistant Helicobacter pylori in dyspeptic patients in western Sydney as determined by testing multiple isolates from different gastric sites. 1998 J. Gastroenterol. Hepatol. pmid:9835322
van Haarst AD et al. The influence of cisapride and clarithromycin on QT intervals in healthy volunteers. 1998 Clin. Pharmacol. Ther. pmid:9834046
Sackoff J et al. Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care. 1998 J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. pmid:9833748
Valsecchi R and Pigatto P Chronic urticaria and Helicobacter pylori. 1998 Acta Derm. Venereol. pmid:9833044
Shafran SD Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals. 1998 Jul-Sep Int. J. Infect. Dis. pmid:9831675
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Anzueto A et al. Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: ciprofloxacin 750 mg b.i.d. versus clarithromycin 500 mg b.i.d. Bronchitis Study Group. 1998 Sep-Oct Clin Ther pmid:9829441
Howden CW and Hunt RH Treating Helicobacter pylori. 1998 Arch. Intern. Med. pmid:9827792
Ward TT et al. Randomized, open-label trial of azithromycin plus ethambutol vs. clarithromycin plus ethambutol as therapy for Mycobacterium avium complex bacteremia in patients with human immunodeficiency virus infection. Veterans Affairs HIV Research Consortium. 1998 Clin. Infect. Dis. pmid:9827282
Kaeser YA et al. Severe hypotension and bradycardia associated with verapamil and clarithromycin. 1998 Am J Health Syst Pharm pmid:9825040
Laine L et al. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. 1998 Am. J. Gastroenterol. pmid:9820381
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Mermelstein HT Clarithromycin-induced delirium in a general hospital. 1998 Nov-Dec Psychosomatics pmid:9819955
Champney WS and Burdine R Macrolide antibiotic inhibition of translation and 50S ribosomal subunit assembly in methicillin-resistant Staphylococcus aureus cells. 1998 Microb. Drug Resist. pmid:9818968
Vrioni G et al. Treatment of disseminated Mycobacterium genavense infection in a murine model with ciprofloxacin, amikacin, ethambutol, clarithromycin and rifabutin. 1998 J. Antimicrob. Chemother. pmid:9818747
Cirioni O et al. In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii. 1998 J. Antimicrob. Chemother. pmid:9818742
Arimori K et al. Characteristic difference in gastrointestinal excretion of clarithromycin and roxithromycin. 1998 Biopharm Drug Dispos pmid:9818709
Björkholm B et al. Rapid PCR detection of Helicobacter pylori-associated virulence and resistance genes directly from gastric biopsy material. 1998 J. Clin. Microbiol. pmid:9817898
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Miehlke S et al. Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection. 1998 Nov-Dec Digestion pmid:9813387
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Hynes B Contact granulomas. 1998 J Otolaryngol pmid:9800633
Bortolotti M et al. Effects of oral clarithromycin and amoxycillin on interdigestive gastrointestinal motility of patients with functional dyspepsia and Helicobacter pylori gastritis. 1998 Aliment. Pharmacol. Ther. pmid:9798808
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Cestari R Ranitidine bismuth citrate (RBC) based triple therapy for 7 days is more effective than RBC plus clarithromycin for 14 days in dyspeptic patients with Helicobacter pylori infection. H. Pylori Lombardy Group. 1998 Aliment. Pharmacol. Ther. pmid:9798804
Shafran SD Clarithromycin prophylaxis for disseminated Mycobacterium avium complex infection--efficacy and acquired resistance. 1998 Clin. Infect. Dis. pmid:9798038
Craft JC et al. Clarithromycin resistance and susceptibility patterns of Mycobacterium avium strains isolated during prophylaxis for disseminated infection in patients with AIDS. 1998 Clin. Infect. Dis. pmid:9798037
Chodosh S et al. Efficacy of oral ciprofloxacin vs. clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group. 1998 Clin. Infect. Dis. pmid:9798025
Ouellet D et al. Pharmacokinetic interaction between ritonavir and clarithromycin. 1998 Clin. Pharmacol. Ther. pmid:9797791
Horgen L et al. Pulsed-exposure and postantibiotic leukocyte enhancement effects of amikacin, clarithromycin, clofazimine, and rifampin against intracellular Mycobacterium avium. 1998 Antimicrob. Agents Chemother. pmid:9797242
Piccolomini R et al. Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans. 1998 Antimicrob. Agents Chemother. pmid:9797240
Langan C et al. Short-course cefuroxime axetil therapy in the treatment of acute exacerbations of chronic bronchitis. 1998 Jul-Aug Int. J. Clin. Pract. pmid:9796558
Saika T et al. [A mechanism of clarithromycin resistance in Helicobacter pylori]. 1998 Kansenshogaku Zasshi pmid:9796191
Niang M et al. [Painful nodular lesions]. 1998 Rev Med Interne pmid:9793156
Coudron PE and Stratton CW The bactericidal activity of clarithromycin versus ampicillin alone and in combination with omeprazole and/or bismuth against clarithromycin-susceptible and clarithromycin-resistant strains of Helicobacter pylori. 1998 Diagn. Microbiol. Infect. Dis. pmid:9791756
Borody TJ Helicobacter pylori eradication failure--'salvage' therapies needed. 1998 Ital J Gastroenterol Hepatol pmid:9789131
Finkenbine RD and Frye MD Case of psychosis due to prednisone-clarithromycin interaction. 1998 Gen Hosp Psychiatry pmid:9788033
Sádaba B et al. Concurrent clarithromycin and cyclosporin A treatment. 1998 J. Antimicrob. Chemother. pmid:9786481
Hua J et al. Characterization of clinical isolates of Helicobacter pylori in Singapore. 1998 Microbios pmid:9785486
Gangadharam PR Clarithromycin for non-mycobacterial diseases? 1998 Int. J. Tuberc. Lung Dis. pmid:9783536
González Carro P et al. [Efficacy of an ultrashort protocol in the eradication of Helicobacter pylori]. 1998 Rev Esp Enferm Dig pmid:9780793
Aberg JA et al. Eradication of AIDS-related disseminated mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy. 1998 J. Infect. Dis. pmid:9780266
Casswall TH et al. One-week treatment with omeprazole, clarithromycin, and metronidazole in children with Helicobacter pylori infection. 1998 J. Pediatr. Gastroenterol. Nutr. pmid:9779970
Griffith DE Mycobacteria as pathogens of respiratory infection. 1998 Infect. Dis. Clin. North Am. pmid:9779380
Pina M et al. Detection of point mutations associated with resistance of Helicobacter pylori to clarithromycin by hybridization in liquid phase. 1998 J. Clin. Microbiol. pmid:9774580