clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 242

PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
De Wit S et al. Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. 1993 Lancet pmid:8093299
Maurin M and Raoult D In vitro susceptibilities of spotted fever group rickettsiae and Coxiella burnetti to clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8109928
Clarithromycin effectively treats infection in AIDS patients. 1993 Oncology (Williston Park, N.Y.) pmid:8512782
Clark JA and Margolis DM A cutaneous lesion in a patient with AIDS: an unusual presentation of infection due to Mycobacterium avium complex. 1993 Clin. Infect. Dis. pmid:8513064
Alba D et al. [Clarithromycin in the treatment of cerebral toxoplasmosis associated with HIV infection]. 1993 Rev Clin Esp pmid:8516514
Alder J et al. Clarithromycin therapy of experimental Treponema pallidum infections in hamsters. 1993 Antimicrob. Agents Chemother. pmid:8494384
Franck N et al. Treatment of Mycobacterium chelonae-induced skin infection with clarithromycin. 1993 J. Am. Acad. Dermatol. pmid:8496448
Tomioka H et al. [In vitro antimycobacterial activity of clarithromycin and its therapeutic efficacy against Mycobacterium intracellulare infection induced in mice]. 1993 Kekkaku pmid:8497119
Monteforte JS and Wood CA Pneumonia caused by Nocardia nova and Aspergillus fumigatus after cardiac transplantation. 1993 Eur. J. Clin. Microbiol. Infect. Dis. pmid:8500477
Hakkarinen WD Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482929
Luger SW Clarithromycin vs penicillin. 1993 J Fam Pract pmid:8482930
Granier H et al. [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. 1993 Ann Med Interne (Paris) pmid:8141516
MacGowan AR et al. Synergy testing of macrolide combinations using the chequerboard technique. 1993 J. Antimicrob. Chemother. pmid:8144439
Ximenes E et al. [Ciprofloxacin, clarithromycin, rifampin: in vitro bactericidal activity of double and triple drug combinations against strains of atypical mycobacteria]. 1993 Pathol. Biol. pmid:8233629
Peterson WL et al. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. 1993 Am. J. Gastroenterol. pmid:8237933
Romand S et al. In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. 1993 Antimicrob. Agents Chemother. pmid:8285620
Yasuda H et al. Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8239580
Schmidt T et al. Clarithromycin lacks bactericidal activity in cerebrospinal fluid in experimental pneumococcal meningitis. 1993 J. Antimicrob. Chemother. pmid:8288505
Walker LL et al. Clarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin. 1993 Int. J. Lepr. Other Mycobact. Dis. pmid:8326182
Alder J et al. Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. 1993 Antimicrob. Agents Chemother. pmid:8328782
Mor N and Heifets L Inhibition of intracellular growth of Mycobacterium avium by one pulsed exposure of infected macrophages to clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8328792
Lazard T et al. Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. 1993 Antimicrob. Agents Chemother. pmid:8215285
Helm CJ et al. Comparison of topical antibiotics for treating Mycobacterium fortuitum keratitis in an animal model. 1993 Am. J. Ophthalmol. pmid:8250072
Green PA et al. Mycobacterium avium complex parotid lymphadenitis: successful therapy with clarithromycin and ethambutol. 1993 Pediatr. Infect. Dis. J. pmid:8346008
Pialoux G et al. Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. 1993 Clin. Infect. Dis. pmid:8218702
Foltzer MA et al. Bronchopulmonary bacillary angiomatosis. 1993 Chest pmid:8365330
Fraschini F et al. Clarithromycin clinical pharmacokinetics. 1993 Clin Pharmacokinet pmid:8222460
Neu HC and Chick TW Efficacy and safety of clarithromycin compared to cefixime as outpatient treatment of lower respiratory tract infections. 1993 Chest pmid:8222794
Sedlmayr T et al. [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. 1993 Geburtshilfe Frauenheilkd pmid:8370491
Kodama R et al. [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. 1993 Nippon Rinsho pmid:8283646
Hardy DJ Extent and spectrum of the antimicrobial activity of clarithromycin. 1993 Pediatr. Infect. Dis. J. pmid:8295818
Dubois J et al. Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. 1993 Ear Nose Throat J pmid:8313865
Nasu M [Helicobacter pylori infections]. 1993 Nippon Naika Gakkai Zasshi pmid:8315343
Braga PC and Piatti G Sub-lethal concentrations of clarithromycin interfere with the expression of Staphylococcus aureus adhesiveness to human cells. 1993 J Chemother pmid:8371124
Macklin JL et al. A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. 1993 J Chemother pmid:8371127
Ragnaud JM et al. [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. 1993 Presse Med pmid:8378280
Hoffner SE et al. Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. 1993 Antimicrob. Agents Chemother. pmid:8392308
Gevaudan MJ et al. In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. 1993 J. Antimicrob. Chemother. pmid:8392998
Wallace RJ et al. Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. 1993 Ann. Intern. Med. pmid:8357113
Wettengel R et al. Clarithromycin versus cefaclor for the treatment of mild-to-moderate acute bacterial bronchitis. 1993 J. Antimicrob. Chemother. pmid:8360133
Nakashio S et al. [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. 1993 Jpn J Antibiot pmid:8360978
Lonks JR and Medeiros AA High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. 1993 Antimicrob. Agents Chemother. pmid:8239578
Mor N and Heifets L MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. 1993 Antimicrob. Agents Chemother. pmid:8431006
Klopman G et al. Anti-Mycobacterium avium activity of quinolones: in vitro activities. 1993 Antimicrob. Agents Chemother. pmid:8239587
Mazzei T et al. Chemistry and mode of action of macrolides. 1993 J. Antimicrob. Chemother. pmid:7683018
Lazard T et al. Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. 1993 Antimicrob. Agents Chemother. pmid:7684213
Heifets L et al. Mycobacterium avium strains resistant to clarithromycin and azithromycin. 1993 Antimicrob. Agents Chemother. pmid:8031351
Fass RJ Erythromycin, clarithromycin, and azithromycin: use of frequency distribution curves, scattergrams, and regression analyses to compare in vitro activities and describe cross-resistance. 1993 Antimicrob. Agents Chemother. pmid:8257127
Dempsey CL et al. Drug usage evaluation: clarithromycin as sequential therapy. 1993 Hosp Formul pmid:10130382
Goldstein EJ and Citron DM Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. 1993 Antimicrob. Agents Chemother. pmid:8390810