| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Carcinoma, Basal Cell | D002280 | 6 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Heifets LB et al. | Clarithromycin minimal inhibitory and bactericidal concentrations against Mycobacterium avium. | 1992 | Am. Rev. Respir. Dis. | pmid:1532486 |
| Guay DR and Craft JC | Comparative safety and efficacy of clarithromycin and ampicillin in the treatment of out-patients with acute bacterial exacerbation of chronic bronchitis. | 1992 | J. Intern. Med. | pmid:1532615 |
| Ruf B et al. | Failure of clarithromycin in preventing toxoplasmic encephalitis in AIDS patients. | 1992 | J. Acquir. Immune Defic. Syndr. | pmid:1532831 |
| Neu HC | New macrolide antibiotics: azithromycin and clarithromycin. | 1992 | Ann. Intern. Med. | pmid:1310839 |
| Brown BA et al. | Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. | 1992 | Antimicrob. Agents Chemother. | pmid:1317144 |
| Chu SY et al. | Absolute bioavailability of clarithromycin after oral administration in humans. | 1992 | Antimicrob. Agents Chemother. | pmid:1387301 |
| Cohen Y et al. | Activities of WIN-57273, minocycline, clarithromycin, and 14-hydroxy-clarithromycin against Mycobacterium avium complex in human macrophages. | 1992 | Antimicrob. Agents Chemother. | pmid:1332586 |
| Sifrim D et al. | Comparison of the effects of midecamycin acetate and clarithromycin on gastrointestinal motility in man. | 1992 | Drugs Exp Clin Res | pmid:1292916 |
| Dautzenberg B | [Treatment of atypical mycobacterium infections: current state and therapeutic perspectives]. | 1992 | Rev Pneumol Clin | pmid:1296257 |
| Chapelsky MC et al. | Renal tubular enzyme effects of clarithromycin in comparison with gentamicin and placebo in volunteers. | 1992 Jul-Aug | Drug Saf | pmid:1355971 |
| Hoover WW et al. | Clarithromycin in vitro activity enhanced by its major metabolite, 14-hydroxyclarithromycin. | 1992 Mar-Apr | Diagn. Microbiol. Infect. Dis. | pmid:1533827 |
| de Campora E et al. | Comparative efficacy and safety of roxithromycin and clarithromycin in upper respiratory tract infections. | 1992 May-Jun | Diagn. Microbiol. Infect. Dis. | pmid:1535578 |
| Nilsen OG et al. | Macrolide pharmacokinetics and dose scheduling of roxithromycin. | 1992 May-Jun | Diagn. Microbiol. Infect. Dis. | pmid:1535579 |
| Friend DR | Polyacrylate resin microcapsules for taste masking of antibiotics. | 1992 Oct-Dec | J Microencapsul | pmid:1403495 |
| Ruf B et al. | Effectiveness of the macrolide clarithromycin in the treatment of Mycobacterium avium complex infection in HIV-infected patients. | 1992 Sep-Oct | Infection | pmid:1428183 |
| De Wit S et al. | Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. | 1993 | Lancet | pmid:8093299 |
| Maurin M and Raoult D | In vitro susceptibilities of spotted fever group rickettsiae and Coxiella burnetti to clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8109928 |
| Parish LC | Clarithromycin in the treatment of skin and skin structure infections: two multicenter clinical studies. Clarithromycin Study Group. | 1993 | Int. J. Dermatol. | pmid:8340194 |
| Clarithromycin effectively treats infection in AIDS patients. | 1993 | Oncology (Williston Park, N.Y.) | pmid:8512782 | |
| Clark JA and Margolis DM | A cutaneous lesion in a patient with AIDS: an unusual presentation of infection due to Mycobacterium avium complex. | 1993 | Clin. Infect. Dis. | pmid:8513064 |
| Alba D et al. | [Clarithromycin in the treatment of cerebral toxoplasmosis associated with HIV infection]. | 1993 | Rev Clin Esp | pmid:8516514 |
| Alder J et al. | Clarithromycin therapy of experimental Treponema pallidum infections in hamsters. | 1993 | Antimicrob. Agents Chemother. | pmid:8494384 |
| Humphreys JE et al. | A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. | 1993 | J. Antimicrob. Chemother. | pmid:8226438 |
| Franck N et al. | Treatment of Mycobacterium chelonae-induced skin infection with clarithromycin. | 1993 | J. Am. Acad. Dermatol. | pmid:8496448 |
| Scaglione F et al. | Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. | 1993 | J Chemother | pmid:8229150 |
| Tomioka H et al. | [In vitro antimycobacterial activity of clarithromycin and its therapeutic efficacy against Mycobacterium intracellulare infection induced in mice]. | 1993 | Kekkaku | pmid:8497119 |
| Monteforte JS and Wood CA | Pneumonia caused by Nocardia nova and Aspergillus fumigatus after cardiac transplantation. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8500477 |
| Calhoun KH and Hokanson JA | Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. | 1993 | Arch Fam Med | pmid:8111512 |
| Saint-Marc T et al. | [Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases]. | 1993 | Presse Med | pmid:8121903 |
| Hakkarinen WD | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482929 |
| Akiyama H et al. | Interaction of Staphylococcus aureus cells and silk threads in vitro and in mouse skin. | 1993 | J. Dermatol. Sci. | pmid:8136322 |
| Luger SW | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482930 |
| Granier H et al. | [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. | 1993 | Ann Med Interne (Paris) | pmid:8141516 |
| MacGowan AR et al. | Synergy testing of macrolide combinations using the chequerboard technique. | 1993 | J. Antimicrob. Chemother. | pmid:8144439 |
| Vaara M | Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria. | 1993 | Antimicrob. Agents Chemother. | pmid:8383945 |
| Ximenes E et al. | [Ciprofloxacin, clarithromycin, rifampin: in vitro bactericidal activity of double and triple drug combinations against strains of atypical mycobacteria]. | 1993 | Pathol. Biol. | pmid:8233629 |
| Peterson WL et al. | Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. | 1993 | Am. J. Gastroenterol. | pmid:8237933 |
| Romand S et al. | In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. | 1993 | Antimicrob. Agents Chemother. | pmid:8285620 |
| Yasuda H et al. | Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8239580 |
| Schmidt T et al. | Clarithromycin lacks bactericidal activity in cerebrospinal fluid in experimental pneumococcal meningitis. | 1993 | J. Antimicrob. Chemother. | pmid:8288505 |
| Dautzenberg B et al. | Clarithromycin and other antimicrobial agents in the treatment of disseminated Mycobacterium avium infections in patients with acquired immunodeficiency syndrome. | 1993 | Arch. Intern. Med. | pmid:8427539 |
| Walker LL et al. | Clarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin. | 1993 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8326182 |
| Alder J et al. | Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. | 1993 | Antimicrob. Agents Chemother. | pmid:8328782 |
| Mor N and Heifets L | Inhibition of intracellular growth of Mycobacterium avium by one pulsed exposure of infected macrophages to clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8328792 |
| Lazard T et al. | Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. | 1993 | Antimicrob. Agents Chemother. | pmid:8215285 |
| Helm CJ et al. | Comparison of topical antibiotics for treating Mycobacterium fortuitum keratitis in an animal model. | 1993 | Am. J. Ophthalmol. | pmid:8250072 |
| Green PA et al. | Mycobacterium avium complex parotid lymphadenitis: successful therapy with clarithromycin and ethambutol. | 1993 | Pediatr. Infect. Dis. J. | pmid:8346008 |
| Pialoux G et al. | Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. | 1993 | Clin. Infect. Dis. | pmid:8218702 |
| Clinical Perspectives on Clarithromycin in Pediatric Infections. Symposium proceedings. February 19-20, 1993. | 1993 | Pediatr. Infect. Dis. J. | pmid:7905199 | |
| Foltzer MA et al. | Bronchopulmonary bacillary angiomatosis. | 1993 | Chest | pmid:8365330 |
| Fraschini F et al. | Clarithromycin clinical pharmacokinetics. | 1993 | Clin Pharmacokinet | pmid:8222460 |
| Neu HC and Chick TW | Efficacy and safety of clarithromycin compared to cefixime as outpatient treatment of lower respiratory tract infections. | 1993 | Chest | pmid:8222794 |
| Sedlmayr T et al. | [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. | 1993 | Geburtshilfe Frauenheilkd | pmid:8370491 |
| Kodama R et al. | [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. | 1993 | Nippon Rinsho | pmid:8283646 |
| Chien SM et al. | Treatment of community-acquired pneumonia. A multicenter, double-blind, randomized study comparing clarithromycin with erythromycin. Canada-Sweden Clarithromycin-Pneumonia Study Group. | 1993 | Chest | pmid:8449054 |
| Ji B et al. | Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. | 1993 | J. Infect. Dis. | pmid:8257487 |
| Scaglione F et al. | The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxy clarithromycin. | 1993 | J. Antimicrob. Chemother. | pmid:8262876 |
| Guay DR and Craft JC | Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295810 |
| Hebert AA et al. | Comparative safety and efficacy of clarithromycin and cefadroxil suspensions in the treatment of mild to moderate skin and skin structure infections in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295811 |
| Watanabe Y et al. | Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin. | 1993 | J. Antibiot. | pmid:8501007 |
| Pukander JS et al. | Clarithromycin vs. amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295812 |
| McCarty JM et al. | Comparative safety and efficacy of clarithromycin and amoxicillin/clavulanate in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295813 |
| Gooch WM et al. | Clarithromycin and cefaclor suspensions in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295814 |
| Roig J et al. | Treatment of Legionnaires' disease. Current recommendations. | 1993 | Drugs | pmid:7691508 |
| Still JG et al. | Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295815 |
| Craft JC and Siepman N | Overview of the safety profile of clarithromycin suspension in pediatric patients. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295816 |
| Klein JO | Clarithromycin: where do we go from here? | 1993 | Pediatr. Infect. Dis. J. | pmid:8295817 |
| Hardy DJ | Extent and spectrum of the antimicrobial activity of clarithromycin. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295818 |
| Dubois J et al. | Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. | 1993 | Ear Nose Throat J | pmid:8313865 |
| Nasu M | [Helicobacter pylori infections]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8315343 |
| Braga PC and Piatti G | Sub-lethal concentrations of clarithromycin interfere with the expression of Staphylococcus aureus adhesiveness to human cells. | 1993 | J Chemother | pmid:8371124 |
| Macklin JL et al. | A single-blind, randomised, comparative study of clarithromycin and amoxycillin suspensions in the treatment of children with lower respiratory tract infections. | 1993 | J Chemother | pmid:8371127 |
| Ragnaud JM et al. | [Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. | 1993 | Presse Med | pmid:8378280 |
| Hoffner SE et al. | Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. | 1993 | Antimicrob. Agents Chemother. | pmid:8392308 |
| Gevaudan MJ et al. | In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. | 1993 | J. Antimicrob. Chemother. | pmid:8392998 |
| Wallace RJ et al. | Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. | 1993 | Ann. Intern. Med. | pmid:8357113 |
| Wettengel R et al. | Clarithromycin versus cefaclor for the treatment of mild-to-moderate acute bacterial bronchitis. | 1993 | J. Antimicrob. Chemother. | pmid:8360133 |
| Nakashio S et al. | [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. | 1993 | Jpn J Antibiot | pmid:8360978 |
| Lonks JR and Medeiros AA | High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. | 1993 | Antimicrob. Agents Chemother. | pmid:8239578 |
| Mor N and Heifets L | MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. | 1993 | Antimicrob. Agents Chemother. | pmid:8431006 |
| Klopman G et al. | Anti-Mycobacterium avium activity of quinolones: in vitro activities. | 1993 | Antimicrob. Agents Chemother. | pmid:8239587 |
| Tomioka H et al. | In vitro antimicrobial activity of benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex, determined by the radiometric method. | 1993 | Antimicrob. Agents Chemother. | pmid:8431020 |
| Chu SY et al. | Effect of moderate or severe hepatic impairment on clarithromycin pharmacokinetics. | 1993 | J Clin Pharmacol | pmid:8331208 |
| Graham DY et al. | Clarithromycin for the eradication of Helicobacter pylori. | 1993 | J. Clin. Gastroenterol. | pmid:8331260 |
| Esvant H et al. | [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. | 1993 | Presse Med | pmid:8337221 |
| Lederer J et al. | Clarithromycin treatment of posttraumatic Mycobacterium fortuitum wound infection. | 1993 | Pediatr. Infect. Dis. J. | pmid:8414785 |
| Guay DR et al. | Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. | 1993 | Drug Saf | pmid:8504017 |
| de Vega T et al. | Clarithromycin-induced leukocytoclastic vasculitis. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8404922 |
| Chu S et al. | Single- and multiple-dose pharmacokinetics of clarithromycin, a new macrolide antimicrobial. | 1993 | J Clin Pharmacol | pmid:8408732 |
| Dever LL et al. | Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi. | 1993 | Antimicrob. Agents Chemother. | pmid:8215288 |
| Barradell LB et al. | Clarithromycin. A review of its pharmacological properties and therapeutic use in Mycobacterium avium-intracellulare complex infection in patients with acquired immune deficiency syndrome. | 1993 | Drugs | pmid:7691518 |
| Mazzei T et al. | Chemistry and mode of action of macrolides. | 1993 | J. Antimicrob. Chemother. | pmid:7683018 |
| Lazard T et al. | Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. | 1993 | Antimicrob. Agents Chemother. | pmid:7684213 |
| Emori M et al. | Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. | 1993 | Antimicrob. Agents Chemother. | pmid:7684214 |
| Heifets L et al. | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8031351 |
| Fass RJ | Erythromycin, clarithromycin, and azithromycin: use of frequency distribution curves, scattergrams, and regression analyses to compare in vitro activities and describe cross-resistance. | 1993 | Antimicrob. Agents Chemother. | pmid:8257127 |
| Holdcroft C | Two new macrolide antibiotics: clarithromycin and azithromycin. | 1993 | Nurse Pract | pmid:8380492 |
| Dempsey CL et al. | Drug usage evaluation: clarithromycin as sequential therapy. | 1993 | Hosp Formul | pmid:10130382 |
| Goldstein EJ and Citron DM | Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. | 1993 | Antimicrob. Agents Chemother. | pmid:8390810 |
| Watanabe Y et al. | Chemical modification of erythromycins. XII. A facile synthesis of clarithromycin (6-O-methylerythromycin A) via 2'-silylethers of erythromycin A derivatives. | 1993 | J. Antibiot. | pmid:8360112 |