| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Carcinoma, Basal Cell | D002280 | 6 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Parola D et al. | [Efficacy and safety of clarithromycin in the treatment of community-acquired pneumonia]. | 2000 | Recenti Prog Med | pmid:10705778 |
| Fonquernie L et al. | [Pseudotumoral abdominal granuloma concomitant with immune reconstitution after antiretroviral treatment]. | 2000 | Presse Med | pmid:10705894 |
| Luman W et al. | One week triple therapy for Helicobacter pylori associated duodenal ulcer disease. | 1999 | Singapore Med J | pmid:10709423 |
| Coelho LG et al. | Once-daily Helicobacter pylori treatment to family members of gastric cancer patients. | 2000 | Am. J. Gastroenterol. | pmid:10710099 |
| Pilotto A et al. | In vitro activity of rifabutin against strains of Helicobacter pylori resistant to metronidazole and clarithromycin. | 2000 | Am. J. Gastroenterol. | pmid:10710100 |
| Kearney DJ and Brousal A | Treatment of Helicobacter pylori infection in clinical practice in the United States: results from 224 patients. | 2000 | Dig. Dis. Sci. | pmid:10711436 |
| Lõivukene K et al. | Metronidazole and clarithromycin susceptibility and the subtypes of vacA of Helicobacter pylori isolates in Estonia. | 2000 | Scand. J. Infect. Dis. | pmid:10716079 |
| Edlund C et al. | Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora. | 2000 | Scand. J. Infect. Dis. | pmid:10716083 |
| Ani AE et al. | Antimicrobial susceptibility test of Helicobacter pylori isolated from Jos, Nigeria. | 1999 Nov-Dec | Trans. R. Soc. Trop. Med. Hyg. | pmid:10717760 |
| Tran JQ et al. | Comparison of the abilities of grepafloxacin and clarithromycin to eradicate potential bacterial pathogens from the sputa of patients with chronic bronchitis: influence of pharmacokinetic and pharmacodynamic variables. | 2000 | J. Antimicrob. Chemother. | pmid:10719007 |
| Brophy DF et al. | Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. | 2000 | Antimicrob. Agents Chemother. | pmid:10722500 |
| Numazaki K et al. | Therapeutic effect of clarithromycin for respiratory-tract infections in children caused by Chlamydia pneumoniae. Research Group of Sapporo for Pediatric Chlamydial Infections. | 2000 | Int. J. Antimicrob. Agents | pmid:10724028 |
| Gomollón F et al. | [Does eliminating Helicobacter pylori mean the healing of the duodenal ulcer? The results of a prospective study in Spain]. | 2000 | Gastroenterol Hepatol | pmid:10726384 |
| Telenti A and Iseman M | Drug-resistant tuberculosis: what do we do now? | 2000 | Drugs | pmid:10730543 |
| Lehmann FS et al. | Effect of ornidazole and clarithromycin resistance on eradication of Helicobacter pylori in peptic ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735923 |
| Miwa H et al. | Cure of Helicobacter pylori infection does not improve symptoms in non-ulcer dyspepsia patients-a double-blind placebo-controlled study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735925 |
| Spinzi GC et al. | Seven-day triple therapy with ranitidine bismuth citrate or omeprazole and two antibiotics for eradication of Helicobacter pylori in duodenal ulcer: a multicentre, randomized, single-blind study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10735926 |
| Blackington E | The gastric demon. An update on Helicobacter pylori infection. | 1999 | Adv Nurse Pract | pmid:10745720 |
| Paton R et al. | Susceptibility testing of Haemophilus influenzae to clarithromycin. | 2000 | J. Antimicrob. Chemother. | pmid:10747833 |
| Shashidhar H et al. | A prospective trial of lansoprazole triple therapy for pediatric Helicobacter pylori infection. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10749411 |
| Joosen EA et al. | Costs and benefits of a test-and-treat strategy in Helicobacter pylori-infected subjects: a prospective intervention study in general practice. | 2000 | Eur J Gastroenterol Hepatol | pmid:10750653 |
| Woo PC et al. | Clarithromycin attenuates cyclophosphamide-induced mucositis in mice. | 2000 | Pharmacol. Res. | pmid:10753551 |
| Bassetti M et al. | Erythromycin resistance in Streptococcus pyogenes in Italy. | 2000 Mar-Apr | Emerging Infect. Dis. | pmid:10756153 |
| Shibuya N et al. | [Effect of clarithromycin on adhesion and infiltration of cancer cells]. | 2000 | Jpn J Antibiot | pmid:10756451 |
| Majima T et al. | [Administration of clarithromycin (CAM) to non-small cell lung cancer]. | 2000 | Jpn J Antibiot | pmid:10756452 |
| Matsunaga Y et al. | [Effect of clarithromycin on KL-8 formation by epidermal keratocytes]. | 2000 | Jpn J Antibiot | pmid:10756455 |
| Miyanohara T et al. | [Effects of macrolides on cultured cells derived from the nose]. | 2000 | Jpn J Antibiot | pmid:10756463 |
| Sato Y et al. | [Effect of long-term administration of small dosages of clarithromycin for the treatment of uterine pyometra]. | 2000 | Jpn J Antibiot | pmid:10756466 |
| Fukushima K et al. | [Outstanding efficacy of a macrolide in a small dosage for the treatment of refractory skin fistula communicating with the thoracic cavity and accompanying pyothorax]. | 2000 | Jpn J Antibiot | pmid:10756469 |
| Douthwaite S et al. | Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. | 2000 | Mol. Microbiol. | pmid:10760175 |
| Matsiota-Bernard P et al. | Comparison of clarithromycin-sensitive and clarithromycin-resistant Mycobacterium avium strains isolated from AIDS patients during therapy regimens including clarithromycin. | 2000 | J. Infect. | pmid:10762111 |
| Benson CA et al. | Clarithromycin or rifabutin alone or in combination for primary prophylaxis of Mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. The AIDS Clinical Trials Group 196/Terry Beirn Community Programs for Clinical Research on AIDS 009 Protocol Team. | 2000 | J. Infect. Dis. | pmid:10762562 |
| MacArthur RD et al. | Effects of Mycobacterium avium complex-infection treatment on cytokine expression in human immunodeficiency virus-infected persons: results of AIDS clinical trials group protocol 853. | 2000 | J. Infect. Dis. | pmid:10762582 |
| Trebesius K et al. | Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation. | 2000 | Gut | pmid:10764702 |
| Schenk BE et al. | Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy. | 2000 | Gut | pmid:10764703 |
| Kadir T et al. | In vitro effects of clarithromycin on human polymorphonuclear leukocyte functions. | 2000 May-Jun | Chemotherapy | pmid:10765036 |
| Gasbarrini A et al. | Efficacy of different Helicobacter pylori eradication regimens in patients affected by insulin-dependent diabetes mellitus. | 2000 | Scand. J. Gastroenterol. | pmid:10766318 |
| Offman E et al. | Oral absorption of clarithromycin in acute illness and during convalescence in patients with community-acquired pneumonia. | 2000 | Chest | pmid:10767245 |
| Bojarski C et al. | Patients with dyspepsia benefit from eradication of Helicobacter pylori if other organic causes for dyspepsia were carefully ruled out. | 2000 | Z Gastroenterol | pmid:10768243 |
| Adamsson I et al. | Microbial ecology and treatment of Helicobacter pylori infections: review. | 2000 | J Chemother | pmid:10768510 |
| Singer J et al. | Symptomatic and health status outcomes in the Canadian randomized MAC treatment trial (CTN010). Canadian HIV Trials Network Protocol 010 Study Group. | 2000 | Int J STD AIDS | pmid:10772083 |
| Najib MM et al. | Cost-effectiveness of sparfloxacin compared with other oral antimicrobials in outpatient treatment of community-acquired pneumonia. | 2000 | Pharmacotherapy | pmid:10772376 |
| Fujimura S et al. | Clarithromycin-susceptible Helicobacter pylori with mutation in 23S rRNA gene by PCR-RFLP method. | 2000 | J. Gastroenterol. | pmid:10777165 |
| Abisheganaden JA et al. | Effect of clarithromycin on experimental rhinovirus-16 colds: a randomized, double-blind, controlled trial. | 2000 | Am. J. Med. | pmid:10781777 |
| Kane CL et al. | Disseminated cutaneous Mycobacterium chelonae infection. | 2000 Mar-Apr | Cancer Control | pmid:10783823 |
| Shibl AM et al. | Penicillin-resistant and -intermediate Streptococcus pneumoniae in Saudi Arabia. | 2000 | J Chemother | pmid:10789552 |
| Waites K et al. | Use of clindamycin disks To detect macrolide resistance mediated by ermB and mefE in Streptococcus pneumoniae isolates from adults and children. | 2000 | J. Clin. Microbiol. | pmid:10790089 |
| Marini RP et al. | Ranitidine bismuth citrate and clarithromycin, alone or in combination, for eradication of Helicobacter mustelae infection in ferrets. | 1999 | Am. J. Vet. Res. | pmid:10791942 |
| Calvet X et al. | A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10792124 |
| Shimizu T et al. | Successful treatment using clarithromycin for a cutaneous lesion caused by Mycobacterium szulgai. | 2000 | Br. J. Dermatol. | pmid:10792258 |
| Vernet Vernet M et al. | [Analysis of indications and diagnosis of the gastroscopies requested by primary care physicians]. | 2000 | Aten Primaria | pmid:10795440 |
| Boyanova L et al. | Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bulgaria. | 2000 | J. Med. Microbiol. | pmid:10798553 |
| Boruchoff SE et al. | The steady-state disposition of indinavir is not altered by the concomitant administration of clarithromycin. | 2000 | Clin. Pharmacol. Ther. | pmid:10801243 |
| Azuma T et al. | Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis. | 2000 | Aliment. Pharmacol. Ther. | pmid:10807427 |
| Suzuki H et al. | Prognostic factors of chronic rhinosinusitis under long-term low-dose macrolide therapy. | 2000 May-Jun | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:10810255 |
| Rhee CS et al. | Effects of clarithromycin on rheological properties of nasal mucus in patients with chronic sinusitis. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10823478 |
| Zuckerman JM | The newer macrolides: azithromycin and clarithromycin. | 2000 | Infect. Dis. Clin. North Am. | pmid:10829265 |
| Flockhart DA et al. | Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome. | 2000 | J Clin Psychopharmacol | pmid:10831018 |
| Spiegel JR et al. | Prolonged ulcerative laryngitis. | 2000 | Ear Nose Throat J | pmid:10832196 |
| Miyashita N et al. | In vitro susceptibility of 7.5-kb common plasmid-free Chlamydia trachomatis strains. | 2000 | Microbiol. Immunol. | pmid:10832970 |
| Gisbert JP et al. | One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication. | 2000 | Eur J Gastroenterol Hepatol | pmid:10833090 |
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| Laine L et al. | Endoscopic biopsy requirements for post-treatment diagnosis of Helicobacter pylori. | 2000 | Gastrointest. Endosc. | pmid:10840297 |
| Romero Gómez M et al. | [Usefulness of Helicobacter pylori antigen detection in stools in the diagnosis of infection and confirming eradication after treatment]. | 2000 | Med Clin (Barc) | pmid:10846675 |
| Baños F et al. | [Effectiveness of omeprazole, clarithromycin and amoxycillin therapy to eradicate Helicobacter pylori in patients with active peptic ulcer. Preliminary results of GENPY study]. | 2000 | Med Clin (Barc) | pmid:10846695 |
| Zullo A et al. | A new highly effective short-term therapy schedule for Helicobacter pylori eradication. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848654 |
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| Katelaris PH et al. | Randomized trial of omeprazole and metronidazole with amoxycillin or clarithromycin for Helicobacter pylori eradication, in a region of high primary metronidazole resistance: the HERO study. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848659 |
| Ammon S et al. | Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848660 |
| Leiper K et al. | Open label trial of oral clarithromycin in active Crohn's disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10848665 |
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| Bortolotti M et al. | Dose-related stimulatory effect of clarithromycin on interdigestive gastroduodenal motility. | 2000 | Digestion | pmid:10899723 |
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