| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Carcinoma, Basal Cell | D002280 | 6 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pamuk ON et al. | Are Turkish Helicobacter pylori strains gaining resistance against clarithromycin? | 2000 | Am. J. Gastroenterol. | pmid:10926000 |
| Hammerschlag MR | Treatment of Chlamydia pneumoniae. | 2000 | Int. J. Antimicrob. Agents | pmid:10926449 |
| Nagaya T et al. | A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. | 2000 | J. Clin. Invest. | pmid:10930442 |
| Van Oijen AH et al. | Review article: treatment of Helicobacter pylori infection with ranitidine bismuth citrate- or proton pump inhibitor-based triple therapies. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930892 |
| Hurenkamp GJ et al. | Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930901 |
| Lai KC et al. | Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930902 |
| Pilotto A et al. | Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930903 |
| Kihira K et al. | Rabeprazole, amoxycillin and low- or high-dose clarithromycin for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930904 |
| Kamada T et al. | Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930905 |
| Savarino V et al. | OAM for cure of Helicobacter pylori infection. | 2000 | Aliment. Pharmacol. Ther. | pmid:10930908 |
| Yamashita H et al. | When can complete regression of low-grade gastric lymphoma of mucosa-associated lymphoid tissue be predicted after helicobacter pylori eradication? | 2000 | Histopathology | pmid:10931236 |
| Gücüyener K et al. | Methyl-prednisolone in neurologic complications of Mycoplasma pneumonia. | 2000 | Indian J Pediatr | pmid:10932970 |
| Theron AJ et al. | Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro. | 2000 | J. Antimicrob. Chemother. | pmid:10933651 |
| Kihara Y and Otsuki M | Interaction of gliclazide and rifampicin. | 2000 | Diabetes Care | pmid:10937528 |
| Morlet-Barla N et al. | [Severe hypoglycemia and recurrence caused by disopyramide-clarithromycin interaction]. | 2000 Jul 8-15 | Presse Med | pmid:10938688 |
| Narita N | "Multi-effect" macrolides. | 2000 | Intern. Med. | pmid:10939528 |
| Shivkumar K | Images in cardiovascular medicine. Labile repolarization from "cell to bedside". | 2000 | Circulation | pmid:10942753 |
| Kamochi H et al. | Clarithromycin associated with torsades de pointes. | 1999 | Jpn. Circ. J. | pmid:10943628 |
| Daudén E et al. | Helicobacter pylori and idiopathic chronic urticaria. | 2000 | Int. J. Dermatol. | pmid:10944090 |
| Sato K and Ebe T | [A study on the effect of combined chemotherapy on Mycobacterium avium complex pulmonary disease]. | 2000 | Kekkaku | pmid:10944891 |
| Katz VL et al. | Mycobacterium chelonae sepsis associated with long-term use of an intravenous catheter for treatment of hyperemesis gravidarum. A case report. | 2000 | J Reprod Med | pmid:10948471 |
| Mayhew BS et al. | An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation. | 2000 | Drug Metab. Dispos. | pmid:10950845 |
| Boxenbaum H | Human in vivo competitive inhibition of P450 substrates: increased plasma concentrations as a function of hepatic extraction ratio and percent inhibition. | 1999 Sep-Dec | J Pharm Pharm Sci | pmid:10953254 |
| Gomollón F et al. | [Cost-effectiveness analysis of 2 strategies of Helicobacter pylori eradication: results of a prospective and randomized study in primary care]. | 2000 | Med Clin (Barc) | pmid:10953829 |
| Piqué JM | [Helicobacter pylori eradication in gastroduodenal ulcer: good, fine and not expensive]. | 2000 | Med Clin (Barc) | pmid:10953833 |
| Fujiue Y et al. | [Results of antimicrobial susceptibilities of strains clinically isolated at 8 institutions in Hiroshima City to major oral antimicrobial drugs, mainly new quinolone drugs. Hiroshima Levofloxacin Susceptibility Surveillance Group]. | 2000 | Jpn J Antibiot | pmid:10955237 |
| Hatipoglu ON and Tasan Y | A comparative efficacy and safety study of clarithromycin, roxithromycin and erythromycin stearate in mild pneumonia. | 2000 | Yonsei Med. J. | pmid:10957888 |
| Dupas JL et al. | [Acid suppression therapy is not required after one-week anti-Helicobacter pylori triple therapy for duodenal ulcer healing]. | 2000 Jun-Jul | Gastroenterol. Clin. Biol. | pmid:10962387 |
| McCarty JM | Clarithromycin in the management of community-acquired pneumonia. | 2000 | Clin Ther | pmid:10963284 |
| Scaglione F et al. | In vitro comparative dynamics of modified-release clarithromycin and of azithromycin. | 2000 Sep-Oct | Chemotherapy | pmid:10965100 |
| Castellote J and Porta F | [Combination of ranitidine and bismuth citrate plus 2 antibiotics in the eradication of Helicobacter pylori]. | 2000 | Med Clin (Barc) | pmid:10965489 |
| Ozkan Y et al. | Clarithromycin targeting to lung: characterization, size distribution and in vivo evaluation of the human serum albumin microspheres. | 2000 | Farmaco | pmid:10966162 |
| Katsura Y et al. | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. | 2000 | J. Med. Chem. | pmid:10966750 |
| Heep M et al. | Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy. | 2000 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10968325 |
| Beyer G et al. | Impact of moxifloxacin versus clarithromycin on normal oropharyngeal microflora. | 2000 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10968328 |
| Gisbert JP et al. | Helicobacter pylori eradication: proton pump inhibitor vs. ranitidine bismuth citrate plus two antibiotics for 1 week-a meta-analysis of efficacy. | 2000 | Aliment. Pharmacol. Ther. | pmid:10971230 |
| Frevel M et al. | Eradication of Helicobacter pylori with pantoprazole and two antibiotics: a comparison of two short-term regimens. | 2000 | Aliment. Pharmacol. Ther. | pmid:10971231 |
| Colin AA | Eradication of mycobacterium abscessus in a chronically infected patient with cystic fibrosis. | 2000 | Pediatr. Pulmonol. | pmid:10973047 |
| Cattoli G et al. | Helicobacter acinonychis eradication leading to the resolution of gastric lesions in tigers. | 2000 | Vet. Rec. | pmid:10975334 |
| Scuderi G et al. | Helicobacter pylori: use of a stool antigen detection test and a six-day triple therapy. | 2000 Jan-Feb | Dig Liver Dis | pmid:10975761 |
| Buzás György M et al. | [Lansoprazole versus ranitidine bismuth citrate containing triple regimens for Helicobacter pylori eradication in patients with duodenal ulcer]. | 2000 | Orv Hetil | pmid:10976194 |
| Sohn YT et al. | Polymorphism of clarithromycin. | 2000 | Arch. Pharm. Res. | pmid:10976587 |
| Bosne-David S et al. | Intrinsic resistance of Mycobacterium tuberculosis to clarithromycin is effectively reversed by subinhibitory concentrations of cell wall inhibitors. | 2000 | J. Antimicrob. Chemother. | pmid:10980165 |
| Denis A et al. | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10987440 |
| Komine M and Tamaki K | An open trial of oral macrolide treatment for psoriasis vulgaris. | 2000 | J. Dermatol. | pmid:10989574 |
| Hentschel E | [Treatment of Helicobacter pylori infections]. | 2000 | Acta Med. Austriaca | pmid:10989677 |
| Bermudez LE et al. | Clarithromycin-resistant mycobacterium avium is still susceptible to treatment with clarithromycin and is virulent in mice. | 2000 | Antimicrob. Agents Chemother. | pmid:10991834 |
| Ohtani H et al. | Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats. | 2000 | Antimicrob. Agents Chemother. | pmid:10991836 |
| Rastogi N et al. | In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4. | 2000 | Antimicrob. Agents Chemother. | pmid:10991870 |
| Cynamon MH et al. | Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model. | 2000 | Antimicrob. Agents Chemother. | pmid:10991883 |
| Howden CW | Treatment of Helicobacter pylori infection: is less more? | 2000 | J. Clin. Gastroenterol. | pmid:10993423 |
| Catalano F et al. | Five-day triple therapy in Helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. | 2000 | J. Clin. Gastroenterol. | pmid:10993428 |
| Testoni PA and Bagnolo F | In dyspeptic patients without gastric phase III of the migrating motor complex, Helicobacter pylori eradication produces no short-term changes in interdigestive motility pattern. | 2000 | Scand. J. Gastroenterol. | pmid:10994618 |
| Mushiroda T et al. | The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. | 2000 | Drug Metab. Dispos. | pmid:10997945 |
| Huang AH et al. | Impact of Helicobacter pylori antimicrobial resistance on the outcome of 1-week lansoprazole-based triple therapy. | 2000 | J. Formos. Med. Assoc. | pmid:11000734 |
| Shimizu T et al. | Case of intrafamilial Helicobacter pylori reinfection after successful eradication therapy. | 2000 | Pediatr. Infect. Dis. J. | pmid:11001123 |
| Bermejo F et al. | [Effects of Helicobacter pylori eradication on the recurrence of gastric ulcer during a 12-month follow up]. | 2000 | Med Clin (Barc) | pmid:11002456 |
| Gisbert JP et al. | Proton pump inhibitor, clarithromycin and either amoxycillin or nitroimidazole: a meta-analysis of eradication of Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012477 |
| Catalano F et al. | Helicobacter pylori-positive duodenal ulcer: three-day antibiotic eradication regimen. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012478 |
| Gomollón F et al. | Third line treatment for Helicobacter pylori: a prospective, culture-guided study in peptic ulcer patients. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012479 |
| Westphal JF | Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. | 2000 | Br J Clin Pharmacol | pmid:11012550 |
| Yanagihara K et al. | Intrapulmonary concentrations of inflammatory cytokines in a mouse model of chronic respiratory infection caused by Pseudomonas aeruginosa. | 2000 | Clin. Exp. Immunol. | pmid:11012620 |
| Alter P et al. | [Impediment of cellular immune response under treatment with ticlopidine in a patient with Staphylococcus aureus endocarditis]. | 2000 | Z Kardiol | pmid:11013974 |
| Makristathis A et al. | Two enzyme immunoassays and PCR for detection of Helicobacter pylori in stool specimens from pediatric patients before and after eradication therapy. | 2000 | J. Clin. Microbiol. | pmid:11015388 |
| Wolfe J et al. | Mycobacterium branderi from both a hand infection and a case of pulmonary disease. | 2000 | J. Clin. Microbiol. | pmid:11015432 |
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| Cirioni O et al. | Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline. | 2000 | J. Antimicrob. Chemother. | pmid:11020255 |
| Alarcón T et al. | Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA. | 2000 | J. Antimicrob. Chemother. | pmid:11020260 |
| Guyot A et al. | Clarithromycin appears to be linked with Clostridium difficile-associated diarrhoea in the elderly. | 2000 | J. Antimicrob. Chemother. | pmid:11020269 |
| Cammarota G et al. | Six-day therapy with ranitidine bismuth citrate plus low-dose clarithromycin and tinidazole to cure Helicobacter pylori infection. | 2000 Jul-Aug | Hepatogastroenterology | pmid:11020908 |
| Umegaki N et al. | Clarithromycin-resistance and point mutations in the 23S rRNA gene in Helicobacter pylori isolates from Japan. | 2000 | J. Gastroenterol. Hepatol. | pmid:11022832 |
| Goh K et al. | Efficacy of a 1-week pantoprazole triple therapy in eradicating Helicobacter pylori in Asian patients. | 2000 | J. Gastroenterol. Hepatol. | pmid:11022833 |
| Giacometti A et al. | Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria. | 2000 | Peptides | pmid:11035200 |
| Giacometti A et al. | In-vitro activity and killing effect of polycationic peptides on methicillin-resistant Staphylococcus aureus and interactions with clinically used antibiotics. | 2000 | Diagn. Microbiol. Infect. Dis. | pmid:11035243 |
| Rea TH | Trials of daily, long-term minocycline and rifampin or clarithromycin and rifampin in the treatment of borderline lepromatous and lepromatous leprosy. | 2000 | Int. J. Lepr. Other Mycobact. Dis. | pmid:11036492 |
| McWhinney PH et al. | Failure to produce detectable antibodies to Legionella pneumophila by an immunocompetent adult. | 2000 | J. Infect. | pmid:11041710 |
| Frank F et al. | Helicobacter pylori infection in recurrent abdominal pain. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045841 |
| Kelley MA et al. | Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin. | 2000 | Clin. Infect. Dis. | pmid:11049784 |
| Giannini E et al. | Influence of Helicobacter pylori eradication therapy on 13C aminopyrine breath test: comparison among omeprazole-, lansoprazole-, or pantoprazole-containing regimens. | 2000 | Am. J. Gastroenterol. | pmid:11051345 |
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| Chow LW et al. | Clarithromycin attenuates mastectomy-induced acute inflammatory response. | 2000 | Clin. Diagn. Lab. Immunol. | pmid:11063500 |
| Herr H and You CH | Relationship between Helicobacter pylori and rosacea: it may be a myth. | 2000 | J. Korean Med. Sci. | pmid:11068993 |
| Wong BC et al. | Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa. | 2000 | Aliment. Pharmacol. Ther. | pmid:11069326 |
| Dunne M et al. | A randomized, double-blind trial comparing azithromycin and clarithromycin in the treatment of disseminated Mycobacterium avium infection in patients with human immunodeficiency virus. | 2000 | Clin. Infect. Dis. | pmid:11073759 |
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| Ferrero M et al. | Factors affecting the variation in antibiotic resistance of Helicobacter pylori over a 3-year period. | 2000 | Int. J. Antimicrob. Agents | pmid:11091043 |
| Yoshida H et al. | Reversal of intra-amniotic Chlamydia trachomatis antigen status. | 2000 | Gynecol. Obstet. Invest. | pmid:11093054 |
| Knower MT et al. | Clarithromycin for safe and cost-effective reduction of cyclosporine doses in lung allograft recipients. | 2000 | South. Med. J. | pmid:11095559 |
| Lucas J et al. | Mycobacterium genavense infection in two aged ferrets with conjunctival lesions. | 2000 | Aust. Vet. J. | pmid:11098383 |
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| Lerro P et al. | CagA seropositivity and the severity of Helicobacter pylori infection in dyspeptic children. | 2000 | Acta Paediatr. | pmid:11106041 |
| Fock KM | Clarithromycin resistance in Helicobacter pylori infection: does it matter? | 2000 | J. Gastroenterol. Hepatol. | pmid:11106085 |
| Hamada H et al. | [A case of pneumonia caused by Mycobacterium avium complex successfully treated with clarithromycin]. | 2000 | Nihon Ronen Igakkai Zasshi | pmid:11109848 |
| Warner A | Clarithromycin--a precipitant for acute psychotic stress. | 2000 Nov-Dec | Psychosomatics | pmid:11110120 |
| Hunt RH et al. | Implications of antibiotic resistance in the management of Helicobacter pylori infection: Canadian Helicobacter Study Group. | 2000 | Can. J. Gastroenterol. | pmid:11111109 |