| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Carcinoma, Basal Cell | D002280 | 6 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Esvant H et al. | [Primary prophylaxis of cerebral toxoplasmosis in AIDS with clarithromycin]. | 1993 | Presse Med | pmid:8337221 |
| Graham DY et al. | Clarithromycin for the eradication of Helicobacter pylori. | 1993 | J. Clin. Gastroenterol. | pmid:8331260 |
| Chu SY et al. | Effect of moderate or severe hepatic impairment on clarithromycin pharmacokinetics. | 1993 | J Clin Pharmacol | pmid:8331208 |
| Mor N and Heifets L | Inhibition of intracellular growth of Mycobacterium avium by one pulsed exposure of infected macrophages to clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8328792 |
| Alder J et al. | Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. | 1993 | Antimicrob. Agents Chemother. | pmid:8328782 |
| Walker LL et al. | Clarithromycin is bactericidal against strains of Mycobacterium leprae resistant and susceptible to dapsone and rifampin. | 1993 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8326182 |
| Nasu M | [Helicobacter pylori infections]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8315343 |
| Dubois J et al. | Efficacy of clarithromycin vs. amoxicillin/clavulanate in the treatment of acute maxillary sinusitis. | 1993 | Ear Nose Throat J | pmid:8313865 |
| Antibiotic gets FDA nod for MAC treatment. | 1994 | Am J Nurs | pmid:8304386 | |
| Hardy DJ | Extent and spectrum of the antimicrobial activity of clarithromycin. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295818 |
| Klein JO | Clarithromycin: where do we go from here? | 1993 | Pediatr. Infect. Dis. J. | pmid:8295817 |
| Craft JC and Siepman N | Overview of the safety profile of clarithromycin suspension in pediatric patients. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295816 |
| Still JG et al. | Comparison of clarithromycin and penicillin VK suspensions in the treatment of children with streptococcal pharyngitis and review of currently available alternative antibiotic therapies. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295815 |
| Gooch WM et al. | Clarithromycin and cefaclor suspensions in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295814 |
| McCarty JM et al. | Comparative safety and efficacy of clarithromycin and amoxicillin/clavulanate in the treatment of acute otitis media in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295813 |
| Pukander JS et al. | Clarithromycin vs. amoxicillin suspensions in the treatment of pediatric patients with acute otitis media. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295812 |
| Hebert AA et al. | Comparative safety and efficacy of clarithromycin and cefadroxil suspensions in the treatment of mild to moderate skin and skin structure infections in children. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295811 |
| Guay DR and Craft JC | Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. | 1993 | Pediatr. Infect. Dis. J. | pmid:8295810 |
| Schmidt T et al. | Clarithromycin lacks bactericidal activity in cerebrospinal fluid in experimental pneumococcal meningitis. | 1993 | J. Antimicrob. Chemother. | pmid:8288505 |
| Romand S et al. | In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. | 1993 | Antimicrob. Agents Chemother. | pmid:8285620 |
| Shafran SD et al. | Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol. MAC Study Group of the Canadian HIV Trials Network. | 1994 | N. Engl. J. Med. | pmid:8284019 |
| Kodama R et al. | [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. | 1993 | Nippon Rinsho | pmid:8283646 |
| Scaglione F et al. | The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxy clarithromycin. | 1993 | J. Antimicrob. Chemother. | pmid:8262876 |
| Ji B et al. | Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. | 1993 | J. Infect. Dis. | pmid:8257487 |
| Fass RJ | Erythromycin, clarithromycin, and azithromycin: use of frequency distribution curves, scattergrams, and regression analyses to compare in vitro activities and describe cross-resistance. | 1993 | Antimicrob. Agents Chemother. | pmid:8257127 |
| Helm CJ et al. | Comparison of topical antibiotics for treating Mycobacterium fortuitum keratitis in an animal model. | 1993 | Am. J. Ophthalmol. | pmid:8250072 |
| Sader HS et al. | In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. | 1993 Aug-Sep | Diagn. Microbiol. Infect. Dis. | pmid:8243035 |
| Klopman G et al. | Anti-Mycobacterium avium activity of quinolones: in vitro activities. | 1993 | Antimicrob. Agents Chemother. | pmid:8239587 |
| Yasuda H et al. | Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8239580 |
| Lonks JR and Medeiros AA | High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. | 1993 | Antimicrob. Agents Chemother. | pmid:8239578 |
| Peterson WL et al. | Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial. | 1993 | Am. J. Gastroenterol. | pmid:8237933 |
| Ximenes E et al. | [Ciprofloxacin, clarithromycin, rifampin: in vitro bactericidal activity of double and triple drug combinations against strains of atypical mycobacteria]. | 1993 | Pathol. Biol. | pmid:8233629 |
| Scaglione F et al. | Immunostimulation by clarithromycin in healthy volunteers and chronic bronchitis patients. | 1993 | J Chemother | pmid:8229150 |
| Humphreys JE et al. | A clarithromycin sensitivity survey in the United Kingdom using Stokes' method. | 1993 | J. Antimicrob. Chemother. | pmid:8226438 |
| Coles SJ et al. | A comparative study of clarithromycin and amoxycillin suspensions in the treatment of pediatric patients with acute otitis media. | 1993 Jul-Aug | Infection | pmid:8225637 |
| Adam D | Clarithromycin 250 mg b.i.d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis. | 1993 Jul-Aug | Infection | pmid:8225636 |
| Scaglione F et al. | A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. | 1993 Nov-Dec | Chemotherapy | pmid:8222870 |
| Neu HC and Chick TW | Efficacy and safety of clarithromycin compared to cefixime as outpatient treatment of lower respiratory tract infections. | 1993 | Chest | pmid:8222794 |
| Fraschini F et al. | Clarithromycin clinical pharmacokinetics. | 1993 | Clin Pharmacokinet | pmid:8222460 |
| Pialoux G et al. | Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. | 1993 | Clin. Infect. Dis. | pmid:8218702 |
| Dever LL et al. | Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi. | 1993 | Antimicrob. Agents Chemother. | pmid:8215288 |
| Lazard T et al. | Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. | 1993 | Antimicrob. Agents Chemother. | pmid:8215285 |
| Onyeji CO et al. | Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:8203849 |
| Chan GP et al. | Clinical trial of clarithromycin for lepromatous leprosy. | 1994 | Antimicrob. Agents Chemother. | pmid:8203847 |
| Labenz J et al. | [Omeprazole modified antibiotic therapy of Helicobacter pylori infection: can clarithromycin be replaced by roxithromycin?]. | 1994 | Leber Magen Darm | pmid:8196468 |
| Meier A et al. | Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare. | 1994 | Antimicrob. Agents Chemother. | pmid:8192472 |
| Spangler SK et al. | Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:8192445 |
| Xiong JH et al. | Further study of the effectiveness of single doses of clarithromycin and minocycline against Mycobacterium leprae in mice. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189087 |
| Gelber RH et al. | Minimal bactericidal concentration of clarithromycin against M. leprae. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189083 |
| Andrews J and Wise R | Disk susceptibility testing for clarithromycin. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8187799 |
| Thijs JC et al. | Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186339 |
| Sundberg L and Cederberg A | Penetration of clarithromycin and its 14-hydroxy metabolite into middle ear effusion in children with secretory otitis media. | 1994 | J. Antimicrob. Chemother. | pmid:8182011 |
| Tsang KW et al. | The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. | 1994 | J. Antimicrob. Chemother. | pmid:8182010 |
| Alder J et al. | Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole. | 1994 | J. Antimicrob. Chemother. | pmid:8182006 |
| Husson RN et al. | Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. | 1994 | J. Pediatr. | pmid:8176574 |
| Wallace RJ et al. | Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173775 |
| Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
| Logan RP et al. | Eradication of Helicobacter pylori with clarithromycin and omeprazole. | 1994 | Gut | pmid:8150340 |
| Labenz J and Stolte M | [Current therapy of Helicobacter pylori infection]. | 1994 | Leber Magen Darm | pmid:8145628 |
| MacGowan AR et al. | Synergy testing of macrolide combinations using the chequerboard technique. | 1993 | J. Antimicrob. Chemother. | pmid:8144439 |
| Yasuda H et al. | Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. | 1994 | Antimicrob. Agents Chemother. | pmid:8141568 |
| Granier H et al. | [Mycobacterium chelonei arthritis in an immunosuppressed patient. Efficacy of the treatment with clarithromycin]. | 1993 | Ann Med Interne (Paris) | pmid:8141516 |
| Ohgaki N | Bacterial biofilm in chronic airway infection. | 1994 | Kansenshogaku Zasshi | pmid:8138670 |
| Akiyama H et al. | Interaction of Staphylococcus aureus cells and silk threads in vitro and in mouse skin. | 1993 | J. Dermatol. Sci. | pmid:8136322 |
| Kanatani MS and Guglielmo BJ | The new macrolides. Azithromycin and clarithromycin. | 1994 | West. J. Med. | pmid:8128699 |
| AIDS patients have a new weapon against MAC infection. | 1994 | RN | pmid:8128150 | |
| Saint-Marc T et al. | [Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases]. | 1993 | Presse Med | pmid:8121903 |
| Calhoun KH and Hokanson JA | Multicenter comparison of clarithromycin and amoxicillin in the treatment of acute maxillary sinusitis. | 1993 | Arch Fam Med | pmid:8111512 |
| Maurin M and Raoult D | In vitro susceptibilities of spotted fever group rickettsiae and Coxiella burnetti to clarithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8109928 |
| Ohmori S et al. | Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats. | 1993 Mar-Apr | Drug Metab. Dispos. | pmid:8097709 |
| De Wit S et al. | Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. | 1993 | Lancet | pmid:8093299 |
| Sieber CC et al. | [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. | 1994 | Schweiz Med Wochenschr | pmid:8091165 |
| Sano M et al. | [Adaptation study for biofilm of the urinary tract via highly complicated bladder model (biofilm model of the urinary tract)--experimental study using automatic simulator of the urinary antimicrobial agent concentration]. | 1994 | Kansenshogaku Zasshi | pmid:8089557 |
| Zahid MA et al. | Mycobacterium chelonae (M. chelonae subspecies chelonae): report of a patient with a sporotrichoid presentation who was successfully treated with clarithromycin and ciprofloxacin. | 1994 | Clin. Infect. Dis. | pmid:8086568 |
| Yew WW et al. | Cholestatic hepatitis in a patient who received clarithromycin therapy for a Mycobacterium chelonae lung infection. | 1994 | Clin. Infect. Dis. | pmid:8086541 |
| Saran BR et al. | Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin. | 1994 | Arch. Ophthalmol. | pmid:8085960 |
| Paffetti A et al. | [Clarithromycin in pediatric age. Personal experience]. | 1994 | Minerva Pediatr. | pmid:8084327 |
| Uveitis associated with rifabutin therapy. | 1994 | MMWR Morb. Mortal. Wkly. Rep. | pmid:8072478 | |
| Fujii K et al. | In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives. | 1994 | Antimicrob. Agents Chemother. | pmid:8067748 |
| al-Assi MT et al. | Clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for Helicobacter pylori infection. | 1994 | Am. J. Gastroenterol. | pmid:8053435 |
| Dautzenberg B et al. | [Treatment with clarithromycin of 173 HIV+ patients with disseminated Mycobacterium avium intracellulare infection]. | 1994 | Rev Mal Respir | pmid:8041990 |
| Lemmen SW et al. | Bactericidal activity of clarithromycin and cefaclor against Streptococcus pneumoniae and Moraxella catarrhalis in healthy volunteers. | 1994 | J. Antimicrob. Chemother. | pmid:8040139 |
| Bonnet E et al. | Clarithromycin: a potent agent against infections due to Mycobacterium marinum. | 1994 | Clin. Infect. Dis. | pmid:8038339 |
| Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
| Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
| Wolinsky E | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:8031406 |
| Heifets L et al. | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8031351 |
| Fish DN et al. | Penetration of clarithromycin into lung tissues from patients undergoing lung resection. | 1994 | Antimicrob. Agents Chemother. | pmid:8031063 |
| Ishida K et al. | In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. | 1994 | Antimicrob. Agents Chemother. | pmid:8031048 |
| Aspin MM et al. | Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. | 1994 | J. Pediatr. | pmid:8021763 |
| Guelar A et al. | [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. | 1994 | Enferm. Infecc. Microbiol. Clin. | pmid:8011719 |
| Terashima T et al. | Pulmonary infection due to Mycobacterium xenopi. | 1994 | Intern. Med. | pmid:8000103 |
| Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
| [Recent advances in macrolide antibiotics: focused on clarithromycin. Discussion]. | 1994 | Jpn J Antibiot | pmid:7990251 | |
| Neri M et al. | Omeprazole, bismuth and clarithromycin in the sequential treatment of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:7986974 |
| al-Assi MT et al. | Clarithromycin-amoxycillin therapy for Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:7986970 |
| Bermudez LE et al. | Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. | 1994 | Antimicrob. Agents Chemother. | pmid:7986018 |
| Inderlied CB et al. | Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:7986017 |
| Klemens SP and Cynamon MH | Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7986001 |
| Roblin PM et al. | Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. | 1994 | Antimicrob. Agents Chemother. | pmid:7979292 |