| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Asthenia | D001247 | 5 associated lipids |
| Hypopharyngeal Neoplasms | D007012 | 1 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arvanitis CD et al. | Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:30150398 |
| Moore KN et al. | Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancer. | 2018 | Gynecol. Oncol. | pmid:30093227 |
| Wang L et al. | STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer. | 2018 | Cancer Sci. | pmid:30076657 |
| Jin W et al. | LC-HRMS quantitation of intact antibody drug conjugate trastuzumab emtansine from rat plasma. | 2018 | Bioanalysis | pmid:29863890 |
| Menchon G et al. | A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. | 2018 | Nat Commun | pmid:29844393 |
| Johnson TA and Singla DK | Breast cancer drug trastuzumab induces cardiac toxicity: evaluation of human epidermal growth factor receptor 2 as a potential diagnostic and prognostic marker. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29842793 |
| Barok M et al. | Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation. | 2018 | BMC Cancer | pmid:29720111 |
| Sakai H et al. | HER2 genomic amplification in circulating tumor DNA and estrogen receptor positivity predict primary resistance to trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer. | 2018 | Breast Cancer | pmid:29700710 |
| Escrivá-de-Romanà S et al. | HER2-positive breast cancer: Current and new therapeutic strategies. | 2018 | Breast | pmid:29631097 |
| Moore KN et al. | FORWARD I: a Phase III study of mirvetuximab soravtansine versus chemotherapy in platinum-resistant ovarian cancer. | 2018 | Future Oncol | pmid:29424243 |
| Ricciardi GRR et al. | Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review. | 2018 | BMC Cancer | pmid:29370839 |
| Yeo W et al. | Efficacy and tolerability of trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. | 2018 | Hong Kong Med J | pmid:29326401 |
| Gligorov J et al. | Emilia: use cunning to survive cancer. | 2018 | Chin Clin Oncol | pmid:29307196 |
| Mohamed HE et al. | Stability assessment of antibody-drug conjugate Trastuzumab emtansine in comparison to parent monoclonal antibody using orthogonal testing protocol. | 2018 | J Pharm Biomed Anal | pmid:29258046 |
| Doroshow DB and LoRusso PM | Trastuzumab emtansine: determining its role in management of HER2+ breast cancer. | 2018 | Future Oncol | pmid:29214842 |
| Hurvitz SA et al. | Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial. | 2018 | Lancet Oncol. | pmid:29175149 |
| Ricci F and Le Tourneau C | Trastuzumab emtansine in HER2-positive metastatic breast cancer: what is the best sequence? | 2018 | Chin Clin Oncol | pmid:29156892 |
| Moore KN et al. | A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer. | 2018 | Future Oncol | pmid:29098867 |
| Zuradelli M et al. | Never too old to fight breast cancer: A case report. | 2018 | Medicine (Baltimore) | pmid:29489698 |
| Madden R et al. | Lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer: A systematic review
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| Vilela MD et al. | Progressively Enlarging Cerebellar Hematoma Concurrent with T-DM1 Treatment. | 2018 | World Neurosurg | pmid:29274446 |
| Nittoli T et al. | Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. | 2018 | Bioorg. Med. Chem. | pmid:29605304 |
| Menderes G et al. | SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine and Ovarian Carcinosarcoma with HER2/Neu Expression. | 2017 | Clin. Cancer Res. | pmid:28679774 |
| Montemurro F | Trastuzumab emtansine in HER2-positive metastatic breast cancer. | 2017 | Lancet Oncol. | pmid:28526537 |
| Li C et al. | A Phase I Pharmacokinetic Study of Trastuzumab Emtansine (T-DM1) in Patients with Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer and Normal or Reduced Hepatic Function. | 2017 | Clin Pharmacokinet | pmid:27995530 |
| Takegawa N et al. | DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance. | 2017 | Int. J. Cancer | pmid:28677116 |
| Mescher C et al. | Left Ventricular Ejection Fraction Screening and Clinical Decision-making in Metastatic HER2-positive Breast Cancer. | 2017 | Anticancer Res. | pmid:28668870 |
| Kmietowicz Z | NICE approves trastuzumab emtansine after deal with drug company. | 2017 | BMJ | pmid:28623237 |
| Krop IE et al. | Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial. | 2017 | Lancet Oncol. | pmid:28526538 |
| Diéras V et al. | Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial. | 2017 | Lancet Oncol. | pmid:28526536 |
| Morimura O et al. | Trastuzumab emtansine suppresses the growth of HER2-positive small-cell lung cancer in preclinical models. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28526406 |
| Menderes G et al. | SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression. | 2017 | Gynecol. Oncol. | pmid:28473206 |
| Moore KN et al. | Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors. | 2017 | Cancer | pmid:28440955 |
| Ito K et al. | Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer. | 2017 | Bioconjug. Chem. | pmid:28402624 |
| Sun X et al. | Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. | 2017 | Bioconjug. Chem. | pmid:28388844 |
| Eckelmann D et al. | Spatial profiling of maytansine during the germination process of Maytenus senegalensis seeds. | 2017 | Fitoterapia | pmid:28385670 |
| Thuss-Patience PC et al. | Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study. | 2017 | Lancet Oncol. | pmid:28343975 |
| Beck A et al. | Strategies and challenges for the next generation of antibody-drug conjugates. | 2017 | Nat Rev Drug Discov | pmid:28303026 |
| Zhong P et al. | αβ integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo. | 2017 | Int J Nanomedicine | pmid:29138558 |
| Li Y et al. | EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer. | 2017 | Int J Nanomedicine | pmid:28894364 |
| Chen SC et al. | Population pharmacokinetics and exposure-response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens. | 2017 | Br J Clin Pharmacol | pmid:28733983 |
| Iwamoto N et al. | LC-MS bioanalysis of Trastuzumab and released emtansine using nano-surface and molecular-orientation limited (nSMOL) proteolysis and liquid-liquid partition in plasma of Trastuzumab emtansine-treated breast cancer patients. | 2017 | J Pharm Biomed Anal | pmid:28648785 |
| Seidel K et al. | Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. | 2017 | Chemistry | pmid:28585348 |
| Lynce F et al. | SAFE-HEaRt: Rationale and Design of a Pilot Study Investigating Cardiac Safety of HER2 Targeted Therapy in Patients with HER2-Positive Breast Cancer and Reduced Left Ventricular Function. | 2017 | Oncologist | pmid:28314836 |
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| Stefan N et al. | Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. | 2017 | Mol. Cancer Ther. | pmid:28258164 |
| Wang H et al. | Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity. | 2017 | Chem. Commun. (Camb.) | pmid:28195282 |
| Zhong P et al. | αβ Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. | 2017 | J Control Release | pmid:27986551 |
| Wang LL et al. | A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. | 2017 | Chemistry | pmid:27935144 |
| Lin J and Zhong JJ | Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. | 2017 | Bioprocess Biosyst Eng | pmid:28382459 |