| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fellous A et al. | Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin. | 1985 | Cancer Res. | pmid:3928146 |
| Banerjee A et al. | Interaction of reduced glutathione with bovine brain tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994709 |
| Huang AB et al. | Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004859 |
| Sato Y et al. | Induction of neurofibrillary tangles in cultured mouse neurons by maytanprine. | 1985 | J. Neurol. Sci. | pmid:4040155 |
| Luduena RF et al. | N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041960 |
| Schibler MJ and Cabral FR | Maytansine-resistant mutants of Chinese hamster ovary cells with an alteration in alpha-tubulin. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041962 |
| Rao PN et al. | Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine. | 1979 | Cancer Res. | pmid:455300 |
| Tanida S et al. | Inhibition of cilia regeneration of Tetrahymena by ansamitocins, new antitumor antibiotics. | 1979 | Antimicrob. Agents Chemother. | pmid:475367 |
| Chahinian AP et al. | Phase I study of weekly maytansine given by iv bolus or 24-hour infusion. | 1979 Nov-Dec | Cancer Treat Rep | pmid:526928 |
| Creagan ET et al. | Phase II evaluation of maytansine in patients with advanced head and neck cancer. | 1979 Nov-Dec | Cancer Treat Rep | pmid:526939 |