| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ado-trastuzumab emtansine (Kadcyla) for HER2-positive metastatic breast cancer. | 2013 | Med Lett Drugs Ther | pmid:24043217 | |
| Mihály Z and Gyõrffy B | [HER2-positive breast cancer: available targeted agents and biomarkers for therapy response]. | 2013 | Magy Onkol | pmid:24107820 |
| Dank M and Tõkés T | [Monoclonal antibody therapy in breast cancer]. | 2013 | Magy Onkol | pmid:24107821 |
| Segraves NL et al. | An isolable acyclic hemiacetal of ansamitocin P-3. | 2012 | Magn Reson Chem | pmid:22374862 |
| Meng H et al. | A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability, and Fast Responsive Drug Release for Targeted Cancer Therapy. | 2017 | Macromol Biosci | pmid:28464449 |
| Storz U | Antibody-drug conjugates: Intellectual property considerations. | 2015 | MAbs | pmid:26292154 |
| Panowski S et al. | Site-specific antibody drug conjugates for cancer therapy. | 2014 Jan-Feb | MAbs | pmid:24423619 |
| Beck A and Reichert JM | Antibody-drug conjugates: present and future. | 2014 Jan-Feb | MAbs | pmid:24423577 |
| Whiteman KR et al. | Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. | 2014 Mar-Apr | MAbs | pmid:24492307 |
| Chen L et al. | In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate. | 2016 | MAbs | pmid:27380163 |
| Beck A et al. | World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, Germany. | 2011 Jul-Aug | MAbs | pmid:21691144 |
| Lutz RJ and Whiteman KR | Antibody-maytansinoid conjugates for the treatment of myeloma. | 2009 Nov-Dec | MAbs | pmid:20068397 |
| Beck A et al. | Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany. | 2012 Nov-Dec | MAbs | pmid:22909934 |
| Thudium K et al. | American Association of Pharmaceutical Scientists National Biotechnology Conference Short Course: Translational Challenges in Developing Antibody-Drug Conjugates: May 24, 2012, San Diego, CA. | 2013 Jan-Feb | MAbs | pmid:23255090 |
| Catcott KC et al. | Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates. | 2016 | MAbs | pmid:26752675 |
| Krop IE et al. | Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. | 2014 | Lancet Oncol. | pmid:24793816 |
| Gnant M et al. | HER2-positive breast cancer: a new piece of the puzzle. | 2014 | Lancet Oncol. | pmid:24793817 |
| Krop IE et al. | Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial. | 2017 | Lancet Oncol. | pmid:28526538 |
| Diéras V et al. | Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial. | 2017 | Lancet Oncol. | pmid:28526536 |
| Thuss-Patience PC et al. | Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study. | 2017 | Lancet Oncol. | pmid:28343975 |