| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperplasia | D006965 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Asthenia | D001247 | 5 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin CM and Hamel E | Effects of inhibitors of tubulin polymerization on GTP hydrolysis. | 1981 | J. Biol. Chem. | pmid:6114958 |
| Schrek R and Stefani SS | Toxicity of microtubular drugs to leukemic lymphocytes. | 1981 | Exp. Mol. Pathol. | pmid:7238845 |
| Stebbings H and van Bueren J | Stability of microtubules from insect ovarioles. | 1981 | Cell Biol. Int. Rep. | pmid:7273149 |
| Tanida S et al. | Ansamitocin analogs from a mutant strain of Nocardia. I. Isolation of the mutant, fermentation and antimicrobial properties. | 1981 | J. Antibiot. | pmid:7275830 |
| Izawa M et al. | Ansamitocin analogs from a mutant strain of Nocardia. II. Isolation and structure. | 1981 | J. Antibiot. | pmid:7275831 |
| Luduena RF and Roach MC | Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls. | 1981 | Arch. Biochem. Biophys. | pmid:7305339 |
| Schatten G and Schatten H | Effects of motility inhibitors during sea urchin fertilization: microfilament inhibitors prevent sperm incorporation and restructuring of fertilized egg cortex, whereas microtubule inhibitors prevent pronuclear migrations. | 1981 | Exp. Cell Res. | pmid:7308293 |
| York J et al. | Binding of maytansinoids to tubulin. | 1981 | Biochem. Pharmacol. | pmid:7317106 |
| Wang XF et al. | [Studies on the antitumor constituents of Maytenus confertiflora Luo et Chen (Celastraceae). II. Isolation and characterization of maytansine and maytanprine from the stems]. | 1981 | Yao Xue Xue Bao | pmid:7324964 |
| Lin CM et al. | Binding of maytansine to tubulin: competition with other mitotic inhibitors. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7255878 |
| Nakahama K et al. | Microbial conversion of ansamitocin. | 1981 | J. Antibiot. | pmid:7333971 |
| Izawa M et al. | Demethylation of ansamitocins and related compounds. | 1981 | J. Antibiot. | pmid:7333972 |
| Izawa M et al. | Hydroxylation of ansamitocin P-3. | 1981 | J. Antibiot. | pmid:7333973 |
| Baskin F et al. | Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells. | 1981 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6943568 |
| Edmonson JH et al. | Phase II study of maytansine in advanced breast cancer. | 1981 May-Jun | Cancer Treat Rep | pmid:7237478 |
| Ono Y et al. | Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. | 1982 | Gan | pmid:6186564 |
| Creech RH et al. | Phase II study of cisplatin, maytansine, and chlorozotocin in small cell lung carcinoma (EST 2578). | 1982 | Cancer Treat Rep | pmid:6282460 |
| Ratanatharathorn V et al. | Phase II evaluation of maytansine in refractory non-Hodgkin's lymphoma: a Southwest Oncology Group study. | 1982 | Cancer Treat Rep | pmid:7093975 |
| Hatano K et al. | Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics. | 1982 | J. Antibiot. | pmid:7174527 |
| Borden EC et al. | Phase II evaluation of dibromodulcitol, ICRF-159, and maytansine for sarcomas. | 1982 | Am. J. Clin. Oncol. | pmid:6956236 |
| Slavik M et al. | Phase II studies in advanced, recurrent pelvic malignancies: conducted by the Gynecologic Oncology Group, Experimental Design and Experience. | 1982 | Am. J. Clin. Oncol. | pmid:6897490 |
| Perdue RE | KB cell culture I. Role in discovery of antitumor agents from higher plants. | 1982 Jul-Aug | J. Nat. Prod. | pmid:7130986 |
| deVere White R et al. | Maytansine as a cause of acute proliferative disorder of bladder urothelium in the rat. | 1983 | Cancer Treat Rep | pmid:6825127 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent adenocarcinoma of the ovary. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6846245 |
| Edmonson JH et al. | Phase II study of maytansine in advanced sarcomas. | 1983 | Cancer Treat Rep | pmid:6850657 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent squamous cell carcinoma of the cervix. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6869315 |
| Ghetti B and Gambetti P | Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies. | 1983 | Brain Res. | pmid:6354362 |
| Fan YJ et al. | [Use of 1,2:5,6-dianhydrogalactitol in combination with maytansine in experimental tumor therapy]. | 1983 | Yao Xue Xue Bao | pmid:6677049 |
| Sabio H et al. | Maytansine in refractory childhood acute lymphocytic leukemia: a Pediatric Oncology Group study. | 1983 | Cancer Treat Rep | pmid:6580069 |
| Tsuruo T et al. | Establishment and properties of vincristine-resistant human myelogenous leukemia K562. | 1983 | Gan | pmid:6580255 |
| Akimoto H et al. | Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones. | 1984 | Chem. Pharm. Bull. | pmid:6437689 |
| Kawai A et al. | Chemical modification of ansamitocins. III. Synthesis and biological effects of 3-acyl esters of maytansinol. | 1984 | Chem. Pharm. Bull. | pmid:6441645 |
| Rebert CS et al. | Effects of vincristine, maytansine, and cis-platinum on behavioral and electrophysiological indices of neurotoxicity in the rat. | 1984 | J Appl Toxicol | pmid:6542922 |
| Roach MC and Ludueña RF | Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin. | 1984 | J. Biol. Chem. | pmid:6480599 |
| Niell HB et al. | Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer. | 1985 | Urology | pmid:2579500 |
| Phase II trials of maytansine, low-dose chlorozotocin, and high-dose chlorozotocin as single agents against advanced measurable adenocarcinoma of the pancreas. Gastrointestinal Tumor Study Group. | 1985 | Cancer Treat Rep | pmid:2859924 | |
| Fan YJ et al. | [Effect of maytansine on the cell cycle of Ehrlich ascites carcinoma cells in mice]. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158164 |
| Ravry MJ et al. | Phase II evaluation of maytansine (NSC 153858) in advanced cancer. A Southeastern Cancer Study Group trial. | 1985 | Am. J. Clin. Oncol. | pmid:3834790 |
| Gupta RS | Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells. | 1985 | J. Natl. Cancer Inst. | pmid:3855475 |
| Fellous A et al. | Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin. | 1985 | Cancer Res. | pmid:3928146 |
| Banerjee A et al. | Interaction of reduced glutathione with bovine brain tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994709 |
| Huang AB et al. | Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004859 |
| Sato Y et al. | Induction of neurofibrillary tangles in cultured mouse neurons by maytanprine. | 1985 | J. Neurol. Sci. | pmid:4040155 |
| Luduena RF et al. | N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041960 |
| Schibler MJ and Cabral FR | Maytansine-resistant mutants of Chinese hamster ovary cells with an alteration in alpha-tubulin. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041962 |
| Duanmu C et al. | Tubulin polymerization with ATP is mediated through the exchangeable GTP site. | 1986 | Biochim. Biophys. Acta | pmid:3004597 |
| Tsuruo T et al. | Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines. | 1986 | Cancer Res. | pmid:3753552 |
| Luduena RF et al. | Interactions of vinblastine and maytansine with tubulin. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3460446 |
| Yalowich JC | Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro. | 1987 | Cancer Res. | pmid:2879622 |
| Takahashi M et al. | Rhizoxin binding to tubulin at the maytansine-binding site. | 1987 | Biochim. Biophys. Acta | pmid:3120782 |