| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperplasia | D006965 | 34 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Asthenia | D001247 | 5 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Suchocki JA and Sneden AT | Characterization of decomposition products of maytansine. | 1987 | J Pharm Sci | pmid:11002812 |
| Yalowich JC | Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro. | 1987 | Cancer Res. | pmid:2879622 |
| Yang JL et al. | [Antitumor activity of trewiasine in vitro and in vivo]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3256213 |
| Sakai K et al. | Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3. | 1988 Sep-Oct | J. Nat. Prod. | pmid:3204376 |
| Ludueña RF et al. | The interaction of phomopsin A with bovine brain tubulin. | 1989 | Arch. Biochem. Biophys. | pmid:2735765 |
| Bai RL et al. | Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. | 1990 | J. Biol. Chem. | pmid:2211617 |
| Dymowski W and Furmanowa M | [Investigating cytostatic substances in tissue of plants Maytenus Molina in in-vitro cultures. II. chromatographic test of extracts from callus of Maytenus wallichiana R. et B]. | 1990 | Acta Pol Pharm | pmid:1669332 |
| Sullivan AS et al. | Interaction of rhizoxin with bovine brain tubulin. | 1990 | Cancer Res. | pmid:2364385 |
| Suwanborirux K et al. | Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes. | 1990 | Experientia | pmid:2298279 |
| Ludueña RF et al. | Effect of phomopsin A on the alkylation of tubulin. | 1990 | Biochem. Pharmacol. | pmid:2337418 |
| Kuo YH et al. | Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata. | 1990 Mar-Apr | J. Nat. Prod. | pmid:2380715 |
| Bai RL et al. | Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. | 1991 | J. Biol. Chem. | pmid:1874739 |
| Mujagić H and Mujagić Z | Detection of pleiotropic drug resistance by the rapid immunofluorescence assay of drug effects on the cell skeleton. | 1991 | Oncology | pmid:2023698 |
| Tan GT et al. | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | 1991 Jan-Feb | J. Nat. Prod. | pmid:1710653 |
| Okamoto K et al. | Therapeutic effect of ansamitocin targeted to tumor by a bispecific monoclonal antibody. | 1992 | Jpn. J. Cancer Res. | pmid:1517150 |
| Yue XF et al. | Cytotoxic activity of trewiasine in 4 human cancer cell lines and 5 murine tumors. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1442109 |
| Chari RV et al. | Immunoconjugates containing novel maytansinoids: promising anticancer drugs. | 1992 | Cancer Res. | pmid:1727373 |
| Li Y et al. | Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1530630 |
| Li Y et al. | Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. | 1992 | Biochem. Pharmacol. | pmid:1739410 |
| Hamel E | Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. | 1992 | Pharmacol. Ther. | pmid:1287674 |
| Novelo M et al. | Cytotoxic constituents from Hyptis verticillata. | 1993 | J. Nat. Prod. | pmid:8277312 |
| Iwasaki S | [Inhibitors of tubulin assembly: specially on rhizoxin-maytansine site ligands]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:8210422 |
| Sawada T et al. | A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin. | 1993 Jul-Aug | Bioconjug. Chem. | pmid:8218485 |
| David B et al. | Rhazinilam mimics the cellular effects of taxol by different mechanisms of action. | 1994 | Cell Motil. Cytoskeleton | pmid:7954858 |
| Sinha S and Jain S | Natural products as anticancer agents. | 1994 | Prog Drug Res | pmid:7916160 |
| Fellous A et al. | Removal of the projection domain of microtubule-associated protein 2 alters its interaction with tubulin. | 1994 | J. Protein Chem. | pmid:7986343 |
| Liu C et al. | Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8710920 |
| Ladino CA et al. | Folate-maytansinoids: target-selective drugs of low molecular weight. | 1997 | Int. J. Cancer | pmid:9399666 |
| Rai SS and Wolff J | The C terminus of beta-tubulin regulates vinblastine-induced tubulin polymerization. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539723 |
| Jordan A et al. | Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. | 1998 | Med Res Rev | pmid:9664292 |
| Werbovetz KA et al. | Purification, characterization, and drug susceptibility of tubulin from Leishmania. | 1999 | Mol. Biochem. Parasitol. | pmid:10029309 |
| Havens CG et al. | Cellular effects of leishmanial tubulin inhibitors on L. donovani. | 2000 | Mol. Biochem. Parasitol. | pmid:11071278 |
| Monneret C and Florent JC | [Targeting of antitumor drugs with monoclonal antibodies]. | 2000 | Bull Cancer | pmid:11125291 |
| Smith S | Technology evaluation: C242-DM1, ImmunoGen Inc. | 2001 | Curr. Opin. Mol. Ther. | pmid:11338934 |
| Ross S et al. | Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate. | 2002 | Cancer Res. | pmid:11980648 |
| Carroll BJ et al. | Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis. | 2002 | J. Am. Chem. Soc. | pmid:11960423 |
| Yu TW et al. | The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12060743 |
| Moss SJ et al. | Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate. | 2002 | J. Am. Chem. Soc. | pmid:12047169 |
| Ranson M and Sliwkowski MX | Perspectives on anti-HER monoclonal antibodies. | 2002 | Oncology | pmid:12422051 |
| Cruz-Monserrate Z et al. | Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. | 2003 | Eur. J. Biochem. | pmid:12950266 |
| Pullen CB et al. | Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia. | 2003 | Phytochemistry | pmid:12620351 |
| Tolcher AW et al. | Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. | 2003 | J. Clin. Oncol. | pmid:12525512 |
| Spiteller P et al. | The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum. | 2003 | J. Am. Chem. Soc. | pmid:14624546 |
| Xie H et al. | Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14634038 |
| Tassone P et al. | Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. | 2004 | Blood | pmid:15292058 |
| Lu C et al. | A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum. | 2004 | J. Antibiot. | pmid:15303496 |
| Cassady JM et al. | Recent developments in the maytansinoid antitumor agents. | 2004 | Chem. Pharm. Bull. | pmid:14709862 |
| Liu Z et al. | An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. | 2004 | J Pharm Biomed Anal | pmid:15533675 |
| Henry MD et al. | A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. | 2004 | Cancer Res. | pmid:15520207 |
| Smith SV | Technology evaluation: cantuzumab mertansine, ImmunoGen. | 2004 | Curr. Opin. Mol. Ther. | pmid:15663331 |