| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperplasia | D006965 | 34 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Asthenia | D001247 | 5 associated lipids |
| Hypopharyngeal Neoplasms | D007012 | 1 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Esteva FJ et al. | What Can We Learn about Antibody-Drug Conjugates from the T-DM1 Experience? | 2015 | Am Soc Clin Oncol Educ Book | pmid:25993162 |
| Martin M and López-Tarruella S | Emerging Therapeutic Options for HER2-Positive Breast Cancer. | 2016 | Am Soc Clin Oncol Educ Book | pmid:27249772 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent adenocarcinoma of the ovary. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6846245 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent squamous cell carcinoma of the cervix. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6869315 |
| Borden EC et al. | Phase II evaluation of dibromodulcitol, ICRF-159, and maytansine for sarcomas. | 1982 | Am. J. Clin. Oncol. | pmid:6956236 |
| Slavik M et al. | Phase II studies in advanced, recurrent pelvic malignancies: conducted by the Gynecologic Oncology Group, Experimental Design and Experience. | 1982 | Am. J. Clin. Oncol. | pmid:6897490 |
| Ravry MJ et al. | Phase II evaluation of maytansine (NSC 153858) in advanced cancer. A Southeastern Cancer Study Group trial. | 1985 | Am. J. Clin. Oncol. | pmid:3834790 |
| Fleming MS et al. | A reversed-phase high-performance liquid chromatography method for analysis of monoclonal antibody-maytansinoid immunoconjugates. | 2005 | Anal. Biochem. | pmid:15840500 |
| Luo Q et al. | Structural Characterization of a Monoclonal Antibody-Maytansinoid Immunoconjugate. | 2016 | Anal. Chem. | pmid:26629796 |
| Sang H et al. | Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry. | 2017 | Anal. Chim. Acta | pmid:28088282 |
| Eichner S et al. | The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. | 2012 | Angew. Chem. Int. Ed. Engl. | pmid:22135226 |
| Monneret C | [Current impact of natural products in the discovery of anticancer drugs]. | 2010 | Ann Pharm Fr | pmid:20637355 |
| Corrigan PA et al. | Ado-trastuzumab emtansine: a HER2-positive targeted antibody-drug conjugate. | 2014 | Ann Pharmacother | pmid:25082874 |
| Leal M et al. | Antibody-drug conjugates: an emerging modality for the treatment of cancer. | 2014 | Ann. N. Y. Acad. Sci. | pmid:25123209 |
| Luduena RF et al. | Interactions of vinblastine and maytansine with tubulin. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3460446 |
| Gebhart G et al. | Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR trial. | 2016 | Ann. Oncol. | pmid:26598545 |
| Foglietta J et al. | Letter to the editor concerning 'Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA'. | 2015 | Ann. Oncol. | pmid:25632067 |
| Olson EM et al. | Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM1 in women with HER2-positive metastatic breast cancer. | 2012 | Ann. Oncol. | pmid:21531783 |
| Sibaud V et al. | T-DM1-related telangiectasias: a potential role in secondary bleeding events. | 2015 | Ann. Oncol. | pmid:25403586 |
| Gradishar WJ | Emerging approaches for treating HER2-positive metastatic breast cancer beyond trastuzumab. | 2013 | Ann. Oncol. | pmid:23827380 |