Fan Y et al. |
Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum. |
2016 |
Appl. Microbiol. Biotechnol. |
pmid:26585444
|
Li S et al. |
Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. |
2016 |
Appl. Microbiol. Biotechnol. |
pmid:26572523
|
Luduena RF and Roach MC |
Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls. |
1981 |
Arch. Biochem. Biophys. |
pmid:7305339
|
Ludueña RF et al. |
The interaction of phomopsin A with bovine brain tubulin. |
1989 |
Arch. Biochem. Biophys. |
pmid:2735765
|
Ma J et al. |
New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum. |
2007 |
Arch. Pharm. Res. |
pmid:17679541
|
Jin W et al. |
LC-HRMS quantitation of intact antibody drug conjugate trastuzumab emtansine from rat plasma. |
2018 |
Bioanalysis |
pmid:29863890
|
Carrasco-Triguero M et al. |
Immunogenicity assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine. |
2013 |
Bioanalysis |
pmid:23641693
|
Dere R et al. |
PK assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine. |
2013 |
Bioanalysis |
pmid:23641694
|
Mandelbaum-Shavit F et al. |
Binding of maytansine to rat brain tubulin. |
1976 |
Biochem. Biophys. Res. Commun. |
pmid:985482
|
Morimura O et al. |
Trastuzumab emtansine suppresses the growth of HER2-positive small-cell lung cancer in preclinical models. |
2017 |
Biochem. Biophys. Res. Commun. |
pmid:28526406
|
Li Y et al. |
Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins. |
1992 |
Biochem. Biophys. Res. Commun. |
pmid:1530630
|
Banerjee A et al. |
Interaction of reduced glutathione with bovine brain tubulin. |
1985 |
Biochem. Biophys. Res. Commun. |
pmid:3994709
|
Huang AB et al. |
Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. |
1985 |
Biochem. Biophys. Res. Commun. |
pmid:4004859
|
Johnson RK et al. |
Stathmokinetic and therapeutic effects of maytansine in mice bearing P388 and L1210 leukemias. |
1978 |
Biochem. Pharmacol. |
pmid:708479
|
York J et al. |
Binding of maytansinoids to tubulin. |
1981 |
Biochem. Pharmacol. |
pmid:7317106
|
Ikeyama S and Takeuchi M |
Antitubulin activities of ansamitocins and maytansinoids. |
1981 |
Biochem. Pharmacol. |
pmid:21043240
|
Ludueña RF et al. |
Effect of phomopsin A on the alkylation of tubulin. |
1990 |
Biochem. Pharmacol. |
pmid:2337418
|
Li Y et al. |
Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. |
1992 |
Biochem. Pharmacol. |
pmid:1739410
|
Lacey E et al. |
Interaction of phomopsin A and related compounds with purified sheep brain tubulin. |
1987 |
Biochem. Pharmacol. |
pmid:3606630
|
Duanmu C et al. |
Tubulin polymerization with ATP is mediated through the exchangeable GTP site. |
1986 |
Biochim. Biophys. Acta |
pmid:3004597
|
Takahashi M et al. |
Rhizoxin binding to tubulin at the maytansine-binding site. |
1987 |
Biochim. Biophys. Acta |
pmid:3120782
|
van Geel R et al. |
Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates. |
2015 |
Bioconjug. Chem. |
pmid:26061183
|
Ito K et al. |
Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer. |
2017 |
Bioconjug. Chem. |
pmid:28402624
|
Sun X et al. |
Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. |
2017 |
Bioconjug. Chem. |
pmid:28388844
|
Sawada T et al. |
A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin. |
1993 Jul-Aug |
Bioconjug. Chem. |
pmid:8218485
|
Chen Y et al. |
Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla). |
2016 |
Bioconjug. Chem. |
pmid:27458087
|
Ponte JF et al. |
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates. |
2016 |
Bioconjug. Chem. |
pmid:27174129
|
Widdison WC et al. |
Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. |
2015 |
Bioconjug. Chem. |
pmid:26355774
|
Wakankar AA et al. |
Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes. |
2010 |
Bioconjug. Chem. |
pmid:20698491
|
Sun X et al. |
Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism. |
2011 |
Bioconjug. Chem. |
pmid:21391620
|
Kellogg BA et al. |
Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage. |
2011 |
Bioconjug. Chem. |
pmid:21425776
|
Kim MT et al. |
Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate. |
2014 |
Bioconjug. Chem. |
pmid:24873191
|
Erickson HK et al. |
Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. |
2010 |
Bioconjug. Chem. |
pmid:19891424
|
Stephan JP et al. |
Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination. |
2008 |
Bioconjug. Chem. |
pmid:18637680
|
Nakao H et al. |
Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells. |
2004 |
Biol. Pharm. Bull. |
pmid:15305028
|
Zhong P et al. |
Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy. |
2016 |
Biomacromolecules |
pmid:27723970
|
Bellat V et al. |
Smart Nanotransformers with Unique Enzyme-Inducible Structural Changes and Drug Release Properties. |
2016 |
Biomacromolecules |
pmid:27180972
|
Arai MA et al. |
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. |
2008 |
Bioorg. Med. Chem. |
pmid:18842418
|
Nittoli T et al. |
Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. |
2018 |
Bioorg. Med. Chem. |
pmid:29605304
|
Lin J and Zhong JJ |
Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. |
2017 |
Bioprocess Biosyst Eng |
pmid:28382459
|
Lin J et al. |
Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum. |
2011 |
Bioresour. Technol. |
pmid:20980145
|
Jia Y and Zhong JJ |
Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum. |
2011 |
Bioresour. Technol. |
pmid:21907573
|
Ning X et al. |
Identification and Engineering of Post-PKS Modification Bottlenecks for Ansamitocin P-3 Titer Improvement in Actinosynnema pretiosum subsp. pretiosum ATCC 31280. |
2017 |
Biotechnol J |
pmid:28881098
|
Du ZQ et al. |
Combination of traditional mutation and metabolic engineering to enhance ansamitocin P-3 production in Actinosynnema pretiosum. |
2017 |
Biotechnol. Bioeng. |
pmid:28782796
|
Oki T |
Cytotoxic and antitumor antibiotics produced by microorganisms. |
1980 |
Biotechnol. Bioeng. |
pmid:6159010
|
Tassone P et al. |
Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. |
2004 |
Blood |
pmid:15292058
|
Matsubara Y |
A Meg by any other name. |
2012 |
Blood |
pmid:22956528
|
Thon JN et al. |
High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production. |
2012 |
Blood |
pmid:22665936
|
Deckert J et al. |
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies. |
2013 |
Blood |
pmid:24002446
|
Palomba ML and Younes A |
In the spotlight: a novel CD37 antibody-drug conjugate. |
2013 |
Blood |
pmid:24235129
|