| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe J et al. | Safety Evaluation of Trastuzumab Emtansine in Japanese Patients with HER2-Positive Advanced Breast Cancer. | In Vivo | pmid:28438884 | |
| Yardley DA et al. | Trastuzumab Emtansine (T-DM1) in Patients With HER2-Positive Metastatic Breast Cancer Previously Treated With Chemotherapy and 2 or More HER2-Targeted Agents: Results From the T-PAS Expanded Access Study. | Cancer J | pmid:26389758 | |
| Muzaffar M et al. | Acute Pancreatitis Associated With Ado-Trastuzumab Emtansine. | Am J Ther | pmid:25756468 | |
| pmid: | ||||
| Hanka LJ and Barnett MS | Microbiological assays and bioautography of maytansine and its homologues. | 1974 | Antimicrob. Agents Chemother. | pmid:15825322 |
| Mandelbaum-Shavit F et al. | Binding of maytansine to rat brain tubulin. | 1976 | Biochem. Biophys. Res. Commun. | pmid:985482 |
| Sieber SM et al. | Pharmacology of antitumor agents from higher plants. | 1976 | Cancer Treat Rep | pmid:136296 |
| Mugera GM and Ward JM | Acute toxicity of maytansine in F344 rats. | 1977 | Cancer Treat Rep | pmid:563288 |
| Bhattacharyya B and Wolff J | Maytansine binding to the vinblastine sites of tubulin. | 1977 | FEBS Lett. | pmid:852577 |
| Kupchan SM et al. | The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolides. | 1977 | J. Org. Chem. | pmid:874612 |
| Hull RN et al. | Studies on tissue culture produced plasminogen activator. I. Preliminary observations and the enhancing effect of colchicine and other antimitotic agents. | 1977 | Thromb. Res. | pmid:18812 |
| Wehrli W | Ansamycins. Chemistry, biosynthesis and biological activity. | 1977 | Top Curr Chem | pmid:74108 |
| Osieka R et al. | Chemotherapy of human colon cancer xenografts in athymic nude mice. | 1977 | Cancer | pmid:144557 |
| Wall ME and Wani MC | Antineoplastic agents from plants. | 1977 | Annu. Rev. Pharmacol. Toxicol. | pmid:326159 |
| Higashide E et al. | Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia. | 1977 Dec 22-29 | Nature | pmid:593392 |
| O'Connell MJ et al. | Phase II trial of maytansine in patients with advanced colorectal carcinoma. | 1978 | Cancer Treat Rep | pmid:356981 |
| Issell BF and Crooke ST | Maytansine. | 1978 | Cancer Treat. Rev. | pmid:367597 |
| Kupchan SM et al. | Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids. | 1978 | J. Med. Chem. | pmid:563462 |
| Sieber SM et al. | Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice. | 1978 | Teratology | pmid:694777 |
| Johnson RK et al. | Stathmokinetic and therapeutic effects of maytansine in mice bearing P388 and L1210 leukemias. | 1978 | Biochem. Pharmacol. | pmid:708479 |
| Eagan RT et al. | Phase II evaluation of maytansine in patients with metastatic lung cancer. | 1978 | Cancer Treat Rep | pmid:709559 |
| Alabaster O and Cassidy M | Flow microfluorometric analysis of P388 murine leukemia after administration of vincristine and maytansine in vivo. | 1978 | J. Natl. Cancer Inst. | pmid:625068 |
| Eagan RT et al. | Early clinical study of an intermittent schedule for maytansine (NSC-153858): brief communication. | 1978 | J. Natl. Cancer Inst. | pmid:628025 |
| Cabanillas F et al. | Phase I study of maytansine using a 3-day schedule. | 1978 | Cancer Treat Rep | pmid:348310 |
| Chabner BA et al. | Initial clinical trials of maytansine, an antitumor plant alkaloid. | 1978 | Cancer Treat Rep | pmid:348311 |
| Blum RH and Kahlert T | Maytansine: a phase I study of an ansa macrolide with antitumor activity. | 1978 | Cancer Treat Rep | pmid:348312 |
| Blum RH et al. | A therapeutic trial of maytansine. | 1978 | Cancer Clin Trials | pmid:757139 |
| Douros J and Suffness M | New natural products of interest under development at the National Cancer Institute. | 1978 | Cancer Chemother. Pharmacol. | pmid:86390 |
| Donoso JA et al. | Maytansine action on fast axoplasmic transport and the ultrastructure of vagal axons. | 1978 | Cancer Res. | pmid:77186 |
| Carter SK | New drugs under clinical evaluation in the United States. | 1978 | Cancer Chemother. Pharmacol. | pmid:155503 |
| Tanida S et al. | Inhibition of cilia regeneration of Tetrahymena by ansamitocins, new antitumor antibiotics. | 1979 | Antimicrob. Agents Chemother. | pmid:475367 |
| Rao PN et al. | Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine. | 1979 | Cancer Res. | pmid:455300 |
| Cabanillas F et al. | Results of a phase II study of maytansine in patients with breast carcinoma and melanoma. | 1979 | Cancer Treat Rep | pmid:371803 |
| Ghetti B | Induction of neurofibrillary degeneration following treatment with maytansine in vivo. | 1979 | Brain Res. | pmid:581857 |
| Maslin DN | [Ansamycins]. | 1979 | Antibiotiki | pmid:37801 |
| Aldrich CD | Pleiotropic phenotype of cultured murine cells resistant to maytansine, vincristine, colchicine, and adriamycin. | 1979 | J. Natl. Cancer Inst. | pmid:224236 |
| Chahinian AP et al. | Phase I study of weekly maytansine given by iv bolus or 24-hour infusion. | 1979 Nov-Dec | Cancer Treat Rep | pmid:526928 |
| Creagan ET et al. | Phase II evaluation of maytansine in patients with advanced head and neck cancer. | 1979 Nov-Dec | Cancer Treat Rep | pmid:526939 |
| Oki T | Cytotoxic and antitumor antibiotics produced by microorganisms. | 1980 | Biotechnol. Bioeng. | pmid:6159010 |
| Ootsu K et al. | Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro. | 1980 | Cancer Res. | pmid:6245801 |
| Tanida S et al. | Ansamitocin-induced synchrony in Tetrahymena pyriformis. | 1980 | J. Gen. Microbiol. | pmid:6777454 |
| Franklin R et al. | A phase I-II study of maytansine utilizing a weekly schedule. | 1980 | Cancer | pmid:7214295 |
| Jaffrey IS et al. | Response to maytansine in a patient with malignant thymoma. | 1980 | Cancer Treat Rep | pmid:7379057 |
| Tanida S et al. | Ansamitocins, maytansinoid antitumor antibiotics. Producing organism, fermentation, and antimicrobial activities. | 1980 | J. Antibiot. | pmid:7380728 |
| Kim SU et al. | Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine. | 1980 | Acta Neuropathol. | pmid:7435167 |
| Friedkin M and Rozengurt E | The role of cytoplasmic microtubules in the regulation of the activity of peptide growth factors. | 1980 | Adv. Enzyme Regul. | pmid:7039258 |
| Neidhart JA et al. | Minimal single-agent activity of maytansine in refractory breast cancer: a Southwest Oncology Group study. | 1980 Apr-May | Cancer Treat Rep | pmid:7427953 |
| Ahmann DL et al. | Phase II study of maytansine and chlorozotocin in patients with disseminated malignant melanoma. | 1980 Apr-May | Cancer Treat Rep | pmid:6448689 |
| Rosenthal S et al. | Phase II study of maytansine in patients with advanced lymphomas: an Eastern Cooperative Oncology Group pilot study. | 1980 Oct-Nov | Cancer Treat Rep | pmid:7459897 |
| Lin CM and Hamel E | Effects of inhibitors of tubulin polymerization on GTP hydrolysis. | 1981 | J. Biol. Chem. | pmid:6114958 |
| Schrek R and Stefani SS | Toxicity of microtubular drugs to leukemic lymphocytes. | 1981 | Exp. Mol. Pathol. | pmid:7238845 |
| Stebbings H and van Bueren J | Stability of microtubules from insect ovarioles. | 1981 | Cell Biol. Int. Rep. | pmid:7273149 |
| Tanida S et al. | Ansamitocin analogs from a mutant strain of Nocardia. I. Isolation of the mutant, fermentation and antimicrobial properties. | 1981 | J. Antibiot. | pmid:7275830 |
| Izawa M et al. | Ansamitocin analogs from a mutant strain of Nocardia. II. Isolation and structure. | 1981 | J. Antibiot. | pmid:7275831 |
| Luduena RF and Roach MC | Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls. | 1981 | Arch. Biochem. Biophys. | pmid:7305339 |
| Schatten G and Schatten H | Effects of motility inhibitors during sea urchin fertilization: microfilament inhibitors prevent sperm incorporation and restructuring of fertilized egg cortex, whereas microtubule inhibitors prevent pronuclear migrations. | 1981 | Exp. Cell Res. | pmid:7308293 |
| York J et al. | Binding of maytansinoids to tubulin. | 1981 | Biochem. Pharmacol. | pmid:7317106 |
| Wang XF et al. | [Studies on the antitumor constituents of Maytenus confertiflora Luo et Chen (Celastraceae). II. Isolation and characterization of maytansine and maytanprine from the stems]. | 1981 | Yao Xue Xue Bao | pmid:7324964 |
| Lin CM et al. | Binding of maytansine to tubulin: competition with other mitotic inhibitors. | 1981 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7255878 |
| Nakahama K et al. | Microbial conversion of ansamitocin. | 1981 | J. Antibiot. | pmid:7333971 |
| Izawa M et al. | Demethylation of ansamitocins and related compounds. | 1981 | J. Antibiot. | pmid:7333972 |
| Izawa M et al. | Hydroxylation of ansamitocin P-3. | 1981 | J. Antibiot. | pmid:7333973 |
| Baskin F et al. | Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells. | 1981 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6943568 |
| Ikeyama S and Takeuchi M | Antitubulin activities of ansamitocins and maytansinoids. | 1981 | Biochem. Pharmacol. | pmid:21043240 |
| Edmonson JH et al. | Phase II study of maytansine in advanced breast cancer. | 1981 May-Jun | Cancer Treat Rep | pmid:7237478 |
| Ono Y et al. | Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. | 1982 | Gan | pmid:6186564 |
| Creech RH et al. | Phase II study of cisplatin, maytansine, and chlorozotocin in small cell lung carcinoma (EST 2578). | 1982 | Cancer Treat Rep | pmid:6282460 |
| Ratanatharathorn V et al. | Phase II evaluation of maytansine in refractory non-Hodgkin's lymphoma: a Southwest Oncology Group study. | 1982 | Cancer Treat Rep | pmid:7093975 |
| Hatano K et al. | Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics. | 1982 | J. Antibiot. | pmid:7174527 |
| Borden EC et al. | Phase II evaluation of dibromodulcitol, ICRF-159, and maytansine for sarcomas. | 1982 | Am. J. Clin. Oncol. | pmid:6956236 |
| Slavik M et al. | Phase II studies in advanced, recurrent pelvic malignancies: conducted by the Gynecologic Oncology Group, Experimental Design and Experience. | 1982 | Am. J. Clin. Oncol. | pmid:6897490 |
| Perdue RE | KB cell culture I. Role in discovery of antitumor agents from higher plants. | 1982 Jul-Aug | J. Nat. Prod. | pmid:7130986 |
| deVere White R et al. | Maytansine as a cause of acute proliferative disorder of bladder urothelium in the rat. | 1983 | Cancer Treat Rep | pmid:6825127 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent adenocarcinoma of the ovary. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6846245 |
| Edmonson JH et al. | Phase II study of maytansine in advanced sarcomas. | 1983 | Cancer Treat Rep | pmid:6850657 |
| Thigpen JT et al. | Phase II study of maytansine in the treatment of advanced or recurrent squamous cell carcinoma of the cervix. A Gynecologic Oncology Group study. | 1983 | Am. J. Clin. Oncol. | pmid:6869315 |
| Ghetti B and Gambetti P | Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies. | 1983 | Brain Res. | pmid:6354362 |
| Fan YJ et al. | [Use of 1,2:5,6-dianhydrogalactitol in combination with maytansine in experimental tumor therapy]. | 1983 | Yao Xue Xue Bao | pmid:6677049 |
| Sabio H et al. | Maytansine in refractory childhood acute lymphocytic leukemia: a Pediatric Oncology Group study. | 1983 | Cancer Treat Rep | pmid:6580069 |
| Tsuruo T et al. | Establishment and properties of vincristine-resistant human myelogenous leukemia K562. | 1983 | Gan | pmid:6580255 |
| Akimoto H et al. | Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones. | 1984 | Chem. Pharm. Bull. | pmid:6437689 |
| Kawai A et al. | Chemical modification of ansamitocins. III. Synthesis and biological effects of 3-acyl esters of maytansinol. | 1984 | Chem. Pharm. Bull. | pmid:6441645 |
| Rebert CS et al. | Effects of vincristine, maytansine, and cis-platinum on behavioral and electrophysiological indices of neurotoxicity in the rat. | 1984 | J Appl Toxicol | pmid:6542922 |
| Roach MC and Ludueña RF | Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin. | 1984 | J. Biol. Chem. | pmid:6480599 |
| Niell HB et al. | Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer. | 1985 | Urology | pmid:2579500 |
| Phase II trials of maytansine, low-dose chlorozotocin, and high-dose chlorozotocin as single agents against advanced measurable adenocarcinoma of the pancreas. Gastrointestinal Tumor Study Group. | 1985 | Cancer Treat Rep | pmid:2859924 | |
| Fan YJ et al. | [Effect of maytansine on the cell cycle of Ehrlich ascites carcinoma cells in mice]. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158164 |
| Ravry MJ et al. | Phase II evaluation of maytansine (NSC 153858) in advanced cancer. A Southeastern Cancer Study Group trial. | 1985 | Am. J. Clin. Oncol. | pmid:3834790 |
| Gupta RS | Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells. | 1985 | J. Natl. Cancer Inst. | pmid:3855475 |
| Fellous A et al. | Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin. | 1985 | Cancer Res. | pmid:3928146 |
| Banerjee A et al. | Interaction of reduced glutathione with bovine brain tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994709 |
| Huang AB et al. | Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004859 |
| Sato Y et al. | Induction of neurofibrillary tangles in cultured mouse neurons by maytanprine. | 1985 | J. Neurol. Sci. | pmid:4040155 |
| Luduena RF et al. | N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041960 |
| Schibler MJ and Cabral FR | Maytansine-resistant mutants of Chinese hamster ovary cells with an alteration in alpha-tubulin. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4041962 |
| Duanmu C et al. | Tubulin polymerization with ATP is mediated through the exchangeable GTP site. | 1986 | Biochim. Biophys. Acta | pmid:3004597 |
| Tsuruo T et al. | Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines. | 1986 | Cancer Res. | pmid:3753552 |
| Luduena RF et al. | Interactions of vinblastine and maytansine with tubulin. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3460446 |
| Takahashi M et al. | Rhizoxin binding to tubulin at the maytansine-binding site. | 1987 | Biochim. Biophys. Acta | pmid:3120782 |
| Lacey E et al. | Interaction of phomopsin A and related compounds with purified sheep brain tubulin. | 1987 | Biochem. Pharmacol. | pmid:3606630 |