Salomon PL and Singh R |
Sensitive ELISA Method for the Measurement of Catabolites of Antibody-Drug Conjugates (ADCs) in Target Cancer Cells. |
2015 |
Mol. Pharm. |
pmid:25738394
|
Mustacchi G et al. |
HER2-positive metastatic breast cancer: a changing scenario. |
2015 |
Crit. Rev. Oncol. Hematol. |
pmid:25748080
|
Muzaffar M et al. |
Acute Pancreatitis Associated With Ado-Trastuzumab Emtansine. |
|
Am J Ther |
pmid:25756468
|
Nguyen-Ngoc T and Raymond E |
Reinvention of chemotherapy: drug conjugates and nanoparticles. |
2015 |
Curr Opin Oncol |
pmid:25783982
|
Weiler D et al. |
Rapid response to trastuzumab emtansine in a patient with HER2-driven lung cancer. |
2015 |
J Thorac Oncol |
pmid:25789838
|
Guerin M et al. |
[Trastuzumab emtansine (Kadcyla(®)) approval in HER2-positive metastatic breast cancers]. |
2015 |
Bull Cancer |
pmid:25790739
|
Niell HB et al. |
Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer. |
1985 |
Urology |
pmid:2579500
|
Widdison W et al. |
Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. |
2015 |
Mol. Pharm. |
pmid:25826705
|
Hong EE et al. |
Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation. |
2015 |
Mol. Pharm. |
pmid:25856201
|
Van den Mooter T et al. |
Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. |
2015 |
Expert Opin Biol Ther |
pmid:25865453
|
Sibaud V et al. |
T-DM1 extravasation: first description. |
2016 |
J Eur Acad Dermatol Venereol |
pmid:25879278
|
Ab O et al. |
IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors. |
2015 |
Mol. Cancer Ther. |
pmid:25904506
|
Hamblett KJ et al. |
AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma. |
2015 |
Mol. Cancer Ther. |
pmid:25931519
|
Dholaria B and Srinivasan S |
T-DM1-related carotenoderma and hand-foot syndrome. |
2015 |
Lancet |
pmid:25933279
|
Kan S et al. |
Gemcitabine treatment enhances HER2 expression in low HER2-expressing breast cancer cells and enhances the antitumor effects of trastuzumab emtansine. |
2015 |
Oncol. Rep. |
pmid:25976081
|
Esteva FJ et al. |
What Can We Learn about Antibody-Drug Conjugates from the T-DM1 Experience? |
2015 |
Am Soc Clin Oncol Educ Book |
pmid:25993162
|
Miranda Romero P and MarÃn Gil R |
Trastuzumab emtansine in locally advanced or metastatic HER2 positive breast cancer; GENESIS-SEFH drug evaluation report. |
2015 |
Farm Hosp |
pmid:26005893
|
Shen BQ et al. |
Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats. |
2015 |
Drug Metab Lett |
pmid:26031461
|
Hayashi T et al. |
Targeting HER2 with T-DM1, an Antibody Cytotoxic Drug Conjugate, is Effective in HER2 Over Expressing Bladder Cancer. |
2015 |
J. Urol. |
pmid:26047983
|
van Geel R et al. |
Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates. |
2015 |
Bioconjug. Chem. |
pmid:26061183
|
Piwko C et al. |
Safety Profile and Costs of Related Adverse Events of Trastuzumab Emtansine for the Treatment of HER2-Positive Locally Advanced or Metastatic Breast Cancer Compared to Capecitabine Plus Lapatinib from the Perspective of the Canadian Health-Care System. |
2015 |
Clin Drug Investig |
pmid:26123628
|
Beerli RR et al. |
Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency. |
2015 |
PLoS ONE |
pmid:26132162
|
Chung YC et al. |
Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1). |
2015 |
PLoS ONE |
pmid:26172389
|
Nguyen M et al. |
Preclinical Efficacy and Safety Assessment of an Antibody-Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma. |
2015 |
Clin. Cancer Res. |
pmid:26240273
|
Michel LL et al. |
T-DM1 as a New Treatment Option for Patients with Metastatic HER2-positive Breast Cancer in Clinical Practice. |
2015 |
Anticancer Res. |
pmid:26254411
|
Storz U |
Antibody-drug conjugates: Intellectual property considerations. |
2015 |
MAbs |
pmid:26292154
|
Gébleux R et al. |
Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates. |
2015 |
Mol. Cancer Ther. |
pmid:26294742
|
Bartsch R et al. |
Activity of T-DM1 in Her2-positive breast cancer brain metastases. |
2015 |
Clin. Exp. Metastasis |
pmid:26303828
|
MartÃnez MT et al. |
Treatment of HER2 positive advanced breast cancer with T-DM1: A review of the literature. |
2016 |
Crit. Rev. Oncol. Hematol. |
pmid:26318092
|
Montero JC et al. |
Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling. |
2015 |
Oncotarget |
pmid:26336133
|
Cosmai L et al. |
Renal toxicity of anticancer agents targeting HER2 and EGFR. |
2015 |
J. Nephrol. |
pmid:26341657
|
Widdison WC et al. |
Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. |
2015 |
Bioconjug. Chem. |
pmid:26355774
|
Yardley DA et al. |
Trastuzumab Emtansine (T-DM1) in Patients With HER2-Positive Metastatic Breast Cancer Previously Treated With Chemotherapy and 2 or More HER2-Targeted Agents: Results From the T-PAS Expanded Access Study. |
|
Cancer J |
pmid:26389758
|
Kan S et al. |
Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells. |
2015 |
BMC Cancer |
pmid:26475267
|
Zhang YG et al. |
Nocardiopsis ansamitocini sp. nov., a new producer of ansamitocin P-3 of the genus Nocardiopsis. |
2016 |
Int. J. Syst. Evol. Microbiol. |
pmid:26486850
|
Askoxylakis V et al. |
Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. |
2016 |
J. Natl. Cancer Inst. |
pmid:26547932
|
Roviello G et al. |
Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives. |
2016 |
Tumour Biol. |
pmid:26566626
|
Li S et al. |
Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. |
2016 |
Appl. Microbiol. Biotechnol. |
pmid:26572523
|
Eisenstein M |
Medicine: Eyes on the target. |
2015 |
Nature |
pmid:26580159
|
Fan Y et al. |
Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum. |
2016 |
Appl. Microbiol. Biotechnol. |
pmid:26585444
|
Gebhart G et al. |
Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR trial. |
2016 |
Ann. Oncol. |
pmid:26598545
|
Müller P et al. |
Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade. |
2015 |
Sci Transl Med |
pmid:26606967
|
Luo Q et al. |
Structural Characterization of a Monoclonal Antibody-Maytansinoid Immunoconjugate. |
2016 |
Anal. Chem. |
pmid:26629796
|
Hamblett KJ et al. |
SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm. |
2015 |
Cancer Res. |
pmid:26631267
|
Singh JC and Lichtman SM |
Targeted Agents for HER2-Positive Breast Cancer: Optimal Use in Older Patients. |
2015 |
Drugs Aging |
pmid:26645293
|
|
T-DM1 Extends Survival in HER2+ Breast Cancer. |
2016 |
Cancer Discov |
pmid:26676162
|
|
Checkpoint Inhibitors Boost Power of Antibody-Drug Conjugate. |
2016 |
Cancer Discov |
pmid:26701087
|
Elsada A et al. |
NICE guidance on trastuzumab emtansine for HER2-positive advanced breast cancer. |
2016 |
Lancet Oncol. |
pmid:26703893
|
Yan H et al. |
Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity. |
2016 |
Mol. Cancer Ther. |
pmid:26712117
|
de Vries CL et al. |
Response of symptomatic brain metastases from HER-2 overexpressing breast cancer with T-DM1. |
2016 |
J. Neurooncol. |
pmid:26732082
|
Catcott KC et al. |
Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates. |
2016 |
MAbs |
pmid:26752675
|
Li JY et al. |
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy. |
2016 |
Cancer Cell |
pmid:26766593
|
Heudi O et al. |
Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry - Method validation and its application to clinical samples. |
2016 |
J Pharm Biomed Anal |
pmid:26771131
|
Kantarjian HM et al. |
A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia. |
2016 |
Clin Lymphoma Myeloma Leuk |
pmid:26775883
|
Jerjian TV et al. |
Antibody-Drug Conjugates: A Clinical Pharmacy Perspective on an Emerging Cancer Therapy. |
2016 |
Pharmacotherapy |
pmid:26799352
|
Yabe N et al. |
[A Case of Advanced Breast Cancer in Which Marked Improvement of Joint Pain Was Obtained with Stepwise Dose Reduction of Trastuzumab Emtansine (T-DM1)]. |
2015 |
Gan To Kagaku Ryoho |
pmid:26805183
|
Raja SM et al. |
Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition. |
2016 |
Oncotarget |
pmid:26859680
|
Squires H et al. |
Trastuzumab Emtansine for Treating HER2-Positive, Unresectable, Locally Advanced or Metastatic Breast Cancer After Treatment with Trastuzumab and a Taxane: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. |
2016 |
Pharmacoeconomics |
pmid:26892972
|
Vankemmelbeke M and Durrant L |
Third-generation antibody drug conjugates for cancer therapy--a balancing act. |
2016 |
Ther Deliv |
pmid:26893243
|
Maass KF et al. |
Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design. |
2016 |
AAPS J |
pmid:26912181
|
Kashiwaba M et al. |
A multicenter Phase II study evaluating the efficacy, safety and pharmacokinetics of trastuzumab emtansine in Japanese patients with heavily pretreated HER2-positive locally recurrent or metastatic breast cancer. |
2016 |
Jpn. J. Clin. Oncol. |
pmid:26917603
|
Baselga J et al. |
Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer. |
2016 |
Clin. Cancer Res. |
pmid:26920887
|
Dillon RL et al. |
Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. |
2016 |
J. Immunother. |
pmid:26938945
|
Shah MH et al. |
Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors. |
2016 |
Invest New Drugs |
pmid:26961907
|
de Goeij BE and Lambert JM |
New developments for antibody-drug conjugate-based therapeutic approaches. |
2016 |
Curr. Opin. Immunol. |
pmid:26963132
|
Lanshoeft C et al. |
Analysis of small molecule antibody-drug conjugate catabolites in rat liver and tumor tissue by liquid extraction surface analysis micro-capillary liquid chromatography/tandem mass spectrometry. |
2016 |
Rapid Commun. Mass Spectrom. |
pmid:26969923
|
Krop IE et al. |
Phase 1b/2a study of trastuzumab emtansine (T-DM1), paclitaxel, and pertuzumab in HER2-positive metastatic breast cancer. |
2016 |
Breast Cancer Res. |
pmid:26979312
|
Shen K et al. |
Safety and Efficacy of Trastuzumab Emtansine in Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: a Meta-analysis. |
2016 |
Sci Rep |
pmid:26979925
|
Frenel JS et al. |
[Trastuzumab emtansine in the systemic treatment of HER-2-positive breast cancer brain metastases]. |
2016 |
Bull Cancer |
pmid:26992855
|
Coiffier B et al. |
A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. |
2016 |
Br. J. Haematol. |
pmid:27010483
|
Ogitani Y et al. |
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. |
2016 |
Clin. Cancer Res. |
pmid:27026201
|
Singh AP et al. |
Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1). |
2016 |
AAPS J |
pmid:27029797
|
Martin M et al. |
Trastuzumab emtansine (T-DM1) plus docetaxel with or without pertuzumab in patients with HER2-positive locally advanced or metastatic breast cancer: results from a phase Ib/IIa study. |
2016 |
Ann. Oncol. |
pmid:27052654
|
Kwon Y et al. |
Telangiectasia and Pulmonary Arterial Hypertension Following Treatment With Trastuzumab Emtansine: A Case Report. |
2016 |
Chest |
pmid:27055712
|
|
T-DM1 Combo Graduates from I-SPY 2. |
2016 |
Cancer Discov |
pmid:27095360
|
Feng L et al. |
Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer. |
2016 |
J. Exp. Clin. Cancer Res. |
pmid:27102688
|
Walles M et al. |
New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats. |
2016 |
Drug Metab. Dispos. |
pmid:27122302
|
Tsuda M et al. |
Abnormal Corneal Lesions Induced by Trastuzumab Emtansine: An Antibody-Drug Conjugate for Breast Cancer. |
2016 |
Cornea |
pmid:27149538
|
Sandra K et al. |
Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine. |
2016 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:27160547
|
Ogitani Y et al. |
Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. |
2016 |
Cancer Sci. |
pmid:27166974
|
Jacot W et al. |
Efficacy and safety of trastuzumab emtansine (T-DM1) in patients with HER2-positive breast cancer with brain metastases. |
2016 |
Breast Cancer Res. Treat. |
pmid:27167986
|
Fan Y et al. |
Effects of modulation of pentose-phosphate pathway on biosynthesis of ansamitocins in Actinosynnema pretiosum. |
2016 |
J. Biotechnol. |
pmid:27173582
|
Ponte JF et al. |
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates. |
2016 |
Bioconjug. Chem. |
pmid:27174129
|
Bellat V et al. |
Smart Nanotransformers with Unique Enzyme-Inducible Structural Changes and Drug Release Properties. |
2016 |
Biomacromolecules |
pmid:27180972
|
Singh R et al. |
A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells. |
2016 |
Mol. Cancer Ther. |
pmid:27197308
|
Hamblett KJ et al. |
Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability. |
2016 |
Mol. Pharm. |
pmid:27248573
|
Martin M and López-Tarruella S |
Emerging Therapeutic Options for HER2-Positive Breast Cancer. |
2016 |
Am Soc Clin Oncol Educ Book |
pmid:27249772
|
Wang C et al. |
Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates. |
2016 |
J Chromatogr A |
pmid:27286648
|
Cilliers C et al. |
Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy. |
2016 |
AAPS J |
pmid:27287046
|
Dzimitrowicz H et al. |
T-DM1 Activity in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers That Received Prior Therapy With Trastuzumab and Pertuzumab. |
2016 |
J. Clin. Oncol. |
pmid:27298406
|
Géraud A et al. |
Preliminary results of the concurrent use of radiotherapy for bone metastases and trastuzumab emtansine in patients with HER2-positive metastatic breast cancer. |
2016 |
Cancer Radiother |
pmid:27342941
|
Ludueña RF et al. |
The interaction of phomopsin A with bovine brain tubulin. |
1989 |
Arch. Biochem. Biophys. |
pmid:2735765
|
Mitsuya K et al. |
Expansive hematoma in delayed cerebral radiation necrosis in patients treated with T-DM1: a report of two cases. |
2016 |
BMC Cancer |
pmid:27377061
|
Chen L et al. |
In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate. |
2016 |
MAbs |
pmid:27380163
|
Li C et al. |
Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer. |
2016 |
Cancer Chemother. Pharmacol. |
pmid:27423671
|
Kim SB et al. |
Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer. |
2016 |
Int. J. Cancer |
pmid:27428671
|
Mahtani RL and Vogel CL |
When Can a Salvage Therapy (T-DM1) Take the Lead? |
2016 |
J. Clin. Oncol. |
pmid:27432926
|
Chen Y et al. |
Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla). |
2016 |
Bioconjug. Chem. |
pmid:27458087
|
Ohashi K et al. |
Trastuzumab Emtansine in HER2+ Recurrent Metastatic Non-Small-Cell Lung Cancer: Study Protocol. |
2017 |
Clin Lung Cancer |
pmid:27497829
|
Eckelmann D et al. |
Occurrence and spatial distribution of maytansinoids in Putterlickia pyracantha, an unexplored resource of anticancer compounds. |
2016 |
Fitoterapia |
pmid:27521896
|