| MeSH term | MeSH ID | Detail |
|---|---|---|
| Breast Neoplasms | D001943 | 24 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of MAYTANSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with MAYTANSINE?
MAYTANSINE is suspected in Myelosuppression, BOSLEY-SALIH-ALORAINY SYNDROME and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with MAYTANSINE
PubChem Associated disorders and diseases
What pathways are associated with MAYTANSINE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with MAYTANSINE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with MAYTANSINE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with MAYTANSINE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with MAYTANSINE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with MAYTANSINE?
Xenograft Model
Xenograft Model are used in the study 'IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.' (Ab O et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with MAYTANSINE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mandelbaum-Shavit F et al. | Binding of maytansine to rat brain tubulin. | 1976 | Biochem. Biophys. Res. Commun. | pmid:985482 |
| Banerjee A et al. | Interaction of reduced glutathione with bovine brain tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3994709 |
| Huang AB et al. | Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004859 |
| Johnson RK et al. | Stathmokinetic and therapeutic effects of maytansine in mice bearing P388 and L1210 leukemias. | 1978 | Biochem. Pharmacol. | pmid:708479 |
| York J et al. | Binding of maytansinoids to tubulin. | 1981 | Biochem. Pharmacol. | pmid:7317106 |
| Ikeyama S and Takeuchi M | Antitubulin activities of ansamitocins and maytansinoids. | 1981 | Biochem. Pharmacol. | pmid:21043240 |
| Ludueña RF et al. | Effect of phomopsin A on the alkylation of tubulin. | 1990 | Biochem. Pharmacol. | pmid:2337418 |
| Li Y et al. | Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. | 1992 | Biochem. Pharmacol. | pmid:1739410 |
| Lacey E et al. | Interaction of phomopsin A and related compounds with purified sheep brain tubulin. | 1987 | Biochem. Pharmacol. | pmid:3606630 |
| Duanmu C et al. | Tubulin polymerization with ATP is mediated through the exchangeable GTP site. | 1986 | Biochim. Biophys. Acta | pmid:3004597 |
| Takahashi M et al. | Rhizoxin binding to tubulin at the maytansine-binding site. | 1987 | Biochim. Biophys. Acta | pmid:3120782 |
| Ito K et al. | Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer. | 2017 | Bioconjug. Chem. | pmid:28402624 |
| Sun X et al. | Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. | 2017 | Bioconjug. Chem. | pmid:28388844 |
| Sawada T et al. | A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin. | 1993 Jul-Aug | Bioconjug. Chem. | pmid:8218485 |
| Chen Y et al. | Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla). | 2016 | Bioconjug. Chem. | pmid:27458087 |
| Ponte JF et al. | Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates. | 2016 | Bioconjug. Chem. | pmid:27174129 |
| Widdison WC et al. | Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. | 2015 | Bioconjug. Chem. | pmid:26355774 |
| Wakankar AA et al. | Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes. | 2010 | Bioconjug. Chem. | pmid:20698491 |
| Sun X et al. | Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism. | 2011 | Bioconjug. Chem. | pmid:21391620 |
| Erickson HK et al. | Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. | 2010 | Bioconjug. Chem. | pmid:19891424 |