Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Oesophagostomiasis | D009814 | 2 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maynard MS and Maynard HD | HPLC assay for avermectin B1a and its two photoisomers using a photo diode array detector. | 1989 | Bull Environ Contam Toxicol | pmid:2804390 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Robertson B | Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. | 1989 | Br. J. Pharmacol. | pmid:2478243 |
| Cui Q et al. | Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression. | 2017 | Biotechnol. Lett. | pmid:28664314 |
| Jiang L et al. | Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. | 2011 | Biotechnol. Lett. | pmid:21691838 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Wei X et al. | Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. | 2006 | Biotechnol. Lett. | pmid:16786277 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |
| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |