Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Oesophagostomiasis | D009814 | 2 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Hafner EW et al. | Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. | 1991 | J. Antibiot. | pmid:2026560 |
| Dutton CJ et al. | Novel avermectins produced by mutational biosynthesis. | 1991 | J. Antibiot. | pmid:2026561 |
| Lasota JA and Dybas RA | Avermectins, a novel class of compounds: implications for use in arthropod pest control. | 1991 | Annu. Rev. Entomol. | pmid:2006872 |
| Mogg TD et al. | Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. | 1990 | Aust. Vet. J. | pmid:2085293 |
| Mann J | Organic chemistry. New routes to natural products. | 1990 | Nature | pmid:2366859 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| Maynard MS and Maynard HD | HPLC assay for avermectin B1a and its two photoisomers using a photo diode array detector. | 1989 | Bull Environ Contam Toxicol | pmid:2804390 |