Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteritis | D001167 | 2 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Silva GRD et al. | Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. | 2017 | Talanta | pmid:28551144 |
| Brownjohn PW et al. | Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. | 2017 | Stem Cell Reports | pmid:28285880 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Jin L et al. | Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. | 2015 | Sci Rep | pmid:26620317 |
| Liu X et al. | Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. | 2017 | Sci Rep | pmid:28303934 |
| Zhao X et al. | Pesticide-mediated interspecific competition between local and invasive thrips pests. | 2017 | Sci Rep | pmid:28084404 |
| Guo J et al. | Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). | 2016 | Sci Rep | pmid:27181521 |
| Sun D et al. | SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. | 2016 | Sci Rep | pmid:27841302 |
| Chen J et al. | Different fates of avermectin and artemisinin in China. | 2016 | Sci China Life Sci | pmid:27132020 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |