Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Oesophagostomiasis | D009814 | 2 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu J et al. | AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. | 2016 | Mol. Microbiol. | pmid:27502190 |
| Guo J et al. | Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). | 2016 | Sci Rep | pmid:27181521 |
| Lemos MA et al. | Development, validation, and application of a method for selected avermectin determination in rural waters using high performance liquid chromatography and fluorescence detection. | 2016 | Ecotoxicol. Environ. Saf. | pmid:27513222 |
| Zhang J et al. | Synthesis, biological activities and structure-activity relationships for new avermectin analogues. | 2016 | Eur J Med Chem | pmid:27318119 |
| Dos Anjos MR et al. | Multiresidue method for simultaneous analysis of aflatoxin M1, avermectins, organophosphate pesticides and milbemycin in milk by ultra-performance liquid chromatography coupled to tandem mass spectrometry. | 2016 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:27144891 |
| Chen J et al. | Different fates of avermectin and artemisinin in China. | 2016 | Sci China Life Sci | pmid:27132020 |
| Del Giudice P | [Nobel prize for ivermectin]. | 2016 | Ann Dermatol Venereol | pmid:27016202 |
| Efferth T et al. | Nobel Prize for artemisinin brings phytotherapy into the spotlight. | 2015 | Phytomedicine | pmid:26563851 |
| Molyneux DH and Ward SA | Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin. | 2015 | Trends Parasitol. | pmid:26552892 |
| Liu C et al. | Avermectin induced autophagy in pigeon spleen tissues. | 2015 | Chem. Biol. Interact. | pmid:26541719 |