Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Jia X et al. | Adhesive polydopamine coated avermectin microcapsules for prolonging foliar pesticide retention. | 2014 | ACS Appl Mater Interfaces | pmid:25390545 |
| Wang F et al. | Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. | 2015 | ACS Chem. Biol. | pmid:25581064 |
| Komatsu M et al. | Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. | 2013 | ACS Synth Biol | pmid:23654282 |
| Todd KS et al. | Anthelmintic efficacy of avermectin B1a and dihydroavermectin B1a against ovine gastrointestinal nematodes in 1977. | 1984 | Am. J. Vet. Res. | pmid:6547280 |
| Wescott RB et al. | Efficacy of avermectin B1a for treatment of experimentally induced nematode infections in cattle. | 1980 | Am. J. Vet. Res. | pmid:6449894 |
| Florez DHÂ et al. | Pipette-tip solid-phase extraction using polypyrrole as efficient adsorbent for extraction of avermectins and milbemycins in milk. | 2018 | Anal Bioanal Chem | pmid:29607449 |
| Schaeffer JM et al. | A chemiluminescent assay for measuring avermectin binding sites. | 1989 | Anal. Biochem. | pmid:2729548 |
| Tom LA and Foster N | Development of a molecularly imprinted polymer for the analysis of avermectin. | 2010 | Anal. Chim. Acta | pmid:20969995 |
| Thompson TS et al. | Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2009 | Anal. Chim. Acta | pmid:19110126 |
| Berendsen BJ et al. | The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. | 2007 | Anal. Chim. Acta | pmid:17386656 |
| Del Giudice P | [Nobel prize for ivermectin]. | 2016 | Ann Dermatol Venereol | pmid:27016202 |
| Długońska H | The Nobel Prize 2015 in physiology or medicine for highly effective antiparasitic drugs. | 2015 | Ann Parasitol | pmid:26878630 |
| Pampiglione S et al. | [Evaluation of the biological activity of avermectin against mosquitoes]. | 1986 | Ann. Ist. Super. Sanita | pmid:2875685 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
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| Lasota JA and Dybas RA | Avermectins, a novel class of compounds: implications for use in arthropod pest control. | 1991 | Annu. Rev. Entomol. | pmid:2006872 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Fisher MH and Mrozik H | The chemistry and pharmacology of avermectins. | 1992 | Annu. Rev. Pharmacol. Toxicol. | pmid:1605577 |
| Mendes AM et al. | Inhibition of Plasmodium Liver Infection by Ivermectin. | 2017 | Antimicrob. Agents Chemother. | pmid:27895022 |
| Haber CL et al. | Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains. | 1991 | Antimicrob. Agents Chemother. | pmid:1719935 |
| Schulman MD et al. | Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins. | 1986 | Antimicrob. Agents Chemother. | pmid:3707112 |
| Ikeda H et al. | Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. | 1988 | Antimicrob. Agents Chemother. | pmid:3364948 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Lim LE et al. | Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165468 |
| Huang J et al. | Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities. | 2015 | Appl. Environ. Microbiol. | pmid:26025902 |
| Liu W et al. | Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. | 2015 | Appl. Environ. Microbiol. | pmid:26002902 |
| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Gao H et al. | Assessing the potential of an induced-mutation strategy for avermectin overproducers. | 2010 | Appl. Environ. Microbiol. | pmid:20453119 |
| Trefzer A et al. | Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. | 2007 | Appl. Environ. Microbiol. | pmid:17483257 |
| Jungmann V et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. | 2005 | Appl. Environ. Microbiol. | pmid:16269732 |
| Molnár I et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. | 2005 | Appl. Environ. Microbiol. | pmid:16269733 |
| Sultan SP et al. | Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27541747 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Qiu J et al. | Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21713508 |
| Kitani S et al. | Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19148632 |
| Gao H et al. | Identification of avermectin-high-producing strains by high-throughput screening methods. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19957083 |
| Jiang X et al. | Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21842154 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Zhang X et al. | Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16708195 |
| Chen L et al. | Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18560830 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| Chen TS and Inamine ES | Studies on the biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2705778 |
| Chen TS et al. | Directed biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2919882 |
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Macdonald N and Gledhill A | Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. | 2007 | Arch. Toxicol. | pmid:17354009 |