Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meinke PT et al. | Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934486 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Lankas GR et al. | Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. | 1998 Jul-Aug | Reprod. Toxicol. | pmid:9717696 |
| Gill JH and Lacey E | Avermectin/milbemycin resistance in trichostrongyloid nematodes. | 1998 | Int. J. Parasitol. | pmid:9673866 |
| Lonneux JF et al. | The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. | 1998 | Vet. Parasitol. | pmid:9653998 |
| Gill JH et al. | Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. | 1998 | Int. J. Parasitol. | pmid:9650059 |
| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
| Barnes TM and Hekimi S | The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. | 1997 | J. Neurochem. | pmid:9375655 |
| Lonneux JF et al. | Antibody response after treatment in cattle infected with Psoroptes ovis. | 1997 Jul-Aug | Res. Vet. Sci. | pmid:9368957 |
| Laughton DL et al. | Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor beta-subunit is expressed solely in the pharynx. | 1997 | J. Exp. Biol. | pmid:9192499 |
| Pomes A et al. | Target size analysis of an avermectin binding site from Drosophila melanogaster. | 1997 | Biochim. Biophys. Acta | pmid:9187243 |
| Huang J and Casida JE | Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103505 |
| Shoop WL et al. | Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024867 |
| Shoop WL et al. | Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024866 |
| McKellar QA and Benchaoui HA | Avermectins and milbemycins. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8905567 |
| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| Herd R | Ecotoxicity of the avermectins: a reply to Forbes. | 1996 | Int. J. Parasitol. | pmid:8818740 |
| Gill JH and Redwin JM | Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. | 1995 | Int. J. Parasitol. | pmid:8719953 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Goudie AC et al. | Doramectin--a potent novel endectocide. | 1993 | Vet. Parasitol. | pmid:8236738 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Slocombe JO and McCraw BM | Evaluation of pyrantel pamoate, nitramisole and avermectin B1a against migrating Strongylus vulgaris larvae. | 1980 | Can. J. Comp. Med. | pmid:7397601 |
| Drummond RO et al. | Control of ticks systemically with Merck MK-933, an avermectin. | 1981 | J. Econ. Entomol. | pmid:7320317 |
| Sano M et al. | Effects of avermectin B1a on the motility of various parasitic helminths. | 1981 | Experientia | pmid:7286134 |
| Lofgren CS and Williams DF | Avermectin B1a: highly potent inhibitor of reproduction by queens of the red imported fire ant (Hymenoptera: Formicidae). | 1982 | J. Econ. Entomol. | pmid:7175003 |
| Campbell WC | Efficacy of the avermectins against filarial parasites: a short review. | 1982 | Vet. Res. Commun. | pmid:7051527 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Yazwinski TA et al. | The effectiveness of ivermectin for reducing bovine gastrointestinal helminthiasis. | 1981 | Vet Med Small Anim Clin | pmid:6911919 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Ishii AI et al. | Studies on chemotherapy of parasitic helminths: effects of avermectin B1a on Angiostrongylus cantonensis in rats. | 1983 | Int. J. Parasitol. | pmid:6685712 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Todd KS et al. | Anthelmintic efficacy of avermectin B1a and dihydroavermectin B1a against ovine gastrointestinal nematodes in 1977. | 1984 | Am. J. Vet. Res. | pmid:6547280 |
| Wescott RB et al. | Efficacy of avermectin B1a for treatment of experimentally induced nematode infections in cattle. | 1980 | Am. J. Vet. Res. | pmid:6449894 |
| Drexler G and Sieghart W | Properties of a high affinity binding site for [3H]avermectin B1a. | 1984 | Eur. J. Pharmacol. | pmid:6329785 |
| Graham D et al. | Avermectin B1a inhibits the binding of strychnine to the glycine receptor of rat spinal cord. | 1982 | Neurosci. Lett. | pmid:6283439 |
| Williams M and Risley EA | Interaction of avermectins with [3H]beta-carboline-3-carboxylate ethyl ester and [3H]diazepam binding sites in rat brain cortical membranes. | 1982 | Eur. J. Pharmacol. | pmid:6277673 |
| Paul SM et al. | Avermectin B1a: an irreversible activator of the gamma-aminobutyric acid-benzodiazepine-chloride-ionophore receptor complex. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6252889 |
| Terada M et al. | Angiostrongylus cantonensis: paralysis due to avermectin B1a and ivermectin. | 1984 | Exp. Parasitol. | pmid:6143682 |
| Miwa GT et al. | The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. | 1982 May-Jun | Drug Metab. Dispos. | pmid:6125361 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Calcott PH and Fatig RO | Avermectin modulation of GABA binding to membranes of rat brain, brine shrimp and a fungus, Mucor miehei. | 1984 | J. Antibiot. | pmid:6088460 |
| Drexler G and Sieghart W | Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor. | 1984 | Eur. J. Pharmacol. | pmid:6088254 |
| Onishi JC and Miller TW | The lack of antifungal activity by avermectin B1a. | 1985 | J. Antibiot. | pmid:4077735 |
| Schulman MD et al. | Demethylavermectins. Biosynthesis, isolation and characterization. | 1985 | J. Antibiot. | pmid:4077729 |
| Pampiglione S et al. | Avermectins, MK-933 and MK-936, for mosquito control. | 1985 | Trans. R. Soc. Trop. Med. Hyg. | pmid:3832491 |
| Schulman MD et al. | Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins. | 1986 | Antimicrob. Agents Chemother. | pmid:3707112 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Seaman JT et al. | Avermectin B1 toxicity in a herd of Murray Grey cattle. | 1987 | Aust. Vet. J. | pmid:3426470 |
| Button C et al. | Avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | Aust. Vet. J. | pmid:3401165 |
| De Chaneet GC et al. | Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle. | 1988 | Aust. Vet. J. | pmid:3401149 |
| Wislocki PG et al. | Dermal penetration of avermectin B1a in the rhesus monkey. | 1988 | Toxicol. Appl. Pharmacol. | pmid:3388421 |
| Ikeda H et al. | Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. | 1988 | Antimicrob. Agents Chemother. | pmid:3364948 |
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Matsumoto K et al. | Actions of avermectins on cultured neurons. | 1988 | Gen. Pharmacol. | pmid:3044917 |
| Wang G et al. | Development of Multifunctional Avermectin Poly(succinimide) Nanoparticles to Improve Bioactivity and Transportation in Rice. | 2018 | J. Agric. Food Chem. | pmid:30299946 |
| Yi Y et al. | Effect of external resistance on the sensitivity of microbial fuel cell biosensor for detection of different types of pollutants. | 2019 | Bioelectrochemistry | pmid:30273855 |
| Rath S et al. | Sorption behaviors of antimicrobial and antiparasitic veterinary drugs on subtropical soils. | 2019 | Chemosphere | pmid:30261417 |
| Merola VM and Eubig PA | Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats. | 2018 | Vet. Clin. North Am. Small Anim. Pract. | pmid:30139545 |
| Türkan F et al. | The toxicological impact of some avermectins on human erythrocytes glutathione S-transferase enzyme. | 2018 | J. Biochem. Mol. Toxicol. | pmid:30091233 |
| Conforti S et al. | Comparative effects of the parasiticide ivermectin on survival and reproduction of adult sepsid flies. | 2018 | Ecotoxicol. Environ. Saf. | pmid:30055386 |
| Greene J and Goldberg RB | Isolation and preliminary characterization of lytic and lysogenic phages with wide host range within the streptomycetes. | 1985 | J. Gen. Microbiol. | pmid:2999304 |
| Guan W et al. | Fabrication of an Effective Avermectin Nanoemulsion Using a Cleavable Succinic Ester Emulsifier. | 2018 | J. Agric. Food Chem. | pmid:29976065 |
| Dos Santos Moreira AM et al. | Hydrophobic Nanoprecipitates of β-Cyclodextrin/Avermectins Inclusion Compounds Reveal Insecticide Activity against Aedes aegypti Larvae and Low Toxicity against Fibroblasts. | 2018 | J. Agric. Food Chem. | pmid:29925239 |
| Florez DHÂ et al. | Pipette-tip solid-phase extraction using polypyrrole as efficient adsorbent for extraction of avermectins and milbemycins in milk. | 2018 | Anal Bioanal Chem | pmid:29607449 |
| Li Y et al. | Modified Lignin with Anionic Surfactant and Its Application in Controlled Release of Avermectin. | 2018 | J. Agric. Food Chem. | pmid:29533641 |
| Gordnier PM et al. | Chitin metabolism: not a target of avermectin/milbemycin activity in insects. | 1987 | J. Antibiot. | pmid:2951358 |
| Liang W et al. | Chitosan-based nanoparticles of avermectin to control pine wood nematodes. | 2018 | Int. J. Biol. Macromol. | pmid:29382581 |
| Cui B et al. | Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques. | 2018 | PLoS ONE | pmid:29360866 |