Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Wang JB et al. | Production of doramectin by rational engineering of the avermectin biosynthetic pathway. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21514826 |
| Li M et al. | Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18824353 |
| Wang XX et al. | Yeast screening from avermectins wastewater and investigation on the ability of its fermentation. | 2011 | Bioprocess Biosyst Eng | pmid:21698347 |
| Gao H et al. | Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. | 2009 | Bioresour. Technol. | pmid:19356927 |
| Li M et al. | Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. | 2010 | Bioresour. Technol. | pmid:20655739 |
| Iwai Y | Anecdote of the ÅŒmura laboratory and the discovery of avermectin. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27885935 |
| Takahashi Y | Continuing fascination of exploration in natural substances from microorganisms. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27885930 |
| Hotta K | Epoch-making milestones in antibiotic exploratory researches in Japan. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27885928 |
| Kokoz YM et al. | Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. | 1999 | Biosci. Rep. | pmid:10841270 |