Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Sangster NC et al. | Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. | 1999 | Exp. Parasitol. | pmid:10072327 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |