Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
| Kamijima M and Casida JE | Regional modification of [(3)H]Ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil, and avermectin B(1a). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10698677 |
| Kokoz YM et al. | Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. | 1999 | Biosci. Rep. | pmid:10841270 |
| Gianelli L et al. | Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). | 2000 | Rapid Commun. Mass Spectrom. | pmid:10918377 |
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| Tsukamoto Y et al. | Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. | 2000 | Bioorg. Med. Chem. | pmid:10968260 |
| Banks BJ et al. | Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. | 2000 | Bioorg. Med. Chem. | pmid:11003146 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Wohlert S et al. | Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. | 2001 | Chem. Biol. | pmid:11451669 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Veale PI | Resistance to macrocyclic lactones in nematodes of goats. | 2002 | Aust. Vet. J. | pmid:12074315 |
| Deger Y et al. | Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. | 2002 | Biol Trace Elem Res | pmid:12117268 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |
| Takahashi Y et al. | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508884 |
| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Martins JR et al. | Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. | 2002 | Exp. Appl. Acarol. | pmid:12593589 |
| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Lamb DC et al. | Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). | 2003 | Biochem. Biophys. Res. Commun. | pmid:12893267 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Korystov YN et al. | Avermectins inhibit multidrug resistance of tumor cells. | 2004 | Eur. J. Pharmacol. | pmid:15189764 |
| Nagai K et al. | Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261257 |
| Rezanka T et al. | Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1526463 |
| Brewer BN et al. | Determination of abamectin in soil samples using high-performance liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15282767 |
| Drinyaev VA et al. | Antitumor effect of avermectins. | 2004 | Eur. J. Pharmacol. | pmid:15464058 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |
| Shi ZH et al. | Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). | 2004 | Pest Manag. Sci. | pmid:15578602 |
| Wen LX et al. | Controlled release of avermectin from porous hollow silica nanoparticles. | 2005 | Pest Manag. Sci. | pmid:15714463 |
| Shen J et al. | Bioconcentration and elimination of avermectin B1 in sturgeon. | 2005 | Environ. Toxicol. Chem. | pmid:15720000 |
| Wei L et al. | Synthesis of new, potent avermectin-like insecticidal agents. | 2005 | Carbohydr. Res. | pmid:15922315 |
| Sun Y et al. | Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida). | 2005 | Chemosphere | pmid:15963808 |
| Kuzmina TA et al. | Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. | 2005 | Vet. Parasitol. | pmid:15979240 |
| Yong JH and Byeon WH | Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. | 2005 | J. Microbiol. | pmid:15995647 |
| Fisher MH and Mrozik H | The chemistry and pharmacology of avermectins. | 1992 | Annu. Rev. Pharmacol. Toxicol. | pmid:1605577 |
| Bowen JM and Vitayavirasak B | Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. | 2005 | Vet. Parasitol. | pmid:16076531 |
| Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
| MacNeil DJ et al. | Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. | 1992 | Gene | pmid:1612425 |
| Erzen NK et al. | Degradation of abamectin and doramectin on sheep grazed pasture. | 2005 | Ecotoxicology | pmid:16215697 |
| Jungmann V et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. | 2005 | Appl. Environ. Microbiol. | pmid:16269732 |
| Molnár I et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. | 2005 | Appl. Environ. Microbiol. | pmid:16269733 |
| Li ZZ et al. | Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. | 2006 | J Control Release | pmid:16388871 |
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| Sun Y et al. | [Effects of avermectin B1a on soil microorganism and earthworm (Eisenia fetida)]. | 2005 | Ying Yong Sheng Tai Xue Bao | pmid:16471355 |
| Turnipseed SB et al. | No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16541409 |
| Beasley CA et al. | Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. | 2006 | J Pharm Biomed Anal | pmid:16554137 |
| Wolstenholme AJ and Rogers AT | Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | 2005 | Parasitology | pmid:16569295 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Zhang X et al. | Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16708195 |
| Oremus G et al. | Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. | 2006 | Vet. Parasitol. | pmid:16769175 |
| Wei X et al. | Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. | 2006 | Biotechnol. Lett. | pmid:16786277 |
| Rajkarnikar A et al. | Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272. | 2006 | Curr. Microbiol. | pmid:16874544 |
| Shi W et al. | Determination of multiresidue of avermectins in bovine liver by an indirect competitive ELISA. | 2006 | J. Agric. Food Chem. | pmid:16910699 |
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| Artho R et al. | Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. | 2007 | Vet. Parasitol. | pmid:17088023 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Zhang C et al. | The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility. | 2006 | J. Am. Chem. Soc. | pmid:17177349 |
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Haber CL et al. | Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains. | 1991 | Antimicrob. Agents Chemother. | pmid:1719935 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| Macdonald N and Gledhill A | Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. | 2007 | Arch. Toxicol. | pmid:17354009 |
| Berendsen BJ et al. | The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. | 2007 | Anal. Chim. Acta | pmid:17386656 |
| Webb L et al. | Effects of avermectin residues in cattle dung on yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae) populations in grazed pastures. | 2007 | Bull. Entomol. Res. | pmid:17411477 |
| Li ZZ et al. | Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. | 2007 | J Nanosci Nanotechnol | pmid:17450791 |
| Trefzer A et al. | Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. | 2007 | Appl. Environ. Microbiol. | pmid:17483257 |
| Hernando MD et al. | Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. | 2007 | J Chromatogr A | pmid:17524410 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Brayden DJ and Griffin J | Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. | 2008 | Vet. Res. Commun. | pmid:17578674 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Im JH et al. | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | 2007 | J. Microbiol. Biotechnol. | pmid:18050961 |
| Rajkarnikar A et al. | Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. | 2007 | J. Microbiol. Biotechnol. | pmid:18062239 |
| Ayers S et al. | Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. | 2008 | J. Antibiot. | pmid:18408323 |