Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Paul SM et al. | Avermectin B1a: an irreversible activator of the gamma-aminobutyric acid-benzodiazepine-chloride-ionophore receptor complex. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6252889 |
| Slocombe JO and McCraw BM | Evaluation of pyrantel pamoate, nitramisole and avermectin B1a against migrating Strongylus vulgaris larvae. | 1980 | Can. J. Comp. Med. | pmid:7397601 |
| Wescott RB et al. | Efficacy of avermectin B1a for treatment of experimentally induced nematode infections in cattle. | 1980 | Am. J. Vet. Res. | pmid:6449894 |
| Sano M et al. | Effects of avermectin B1a on the motility of various parasitic helminths. | 1981 | Experientia | pmid:7286134 |
| Drummond RO et al. | Control of ticks systemically with Merck MK-933, an avermectin. | 1981 | J. Econ. Entomol. | pmid:7320317 |
| Yazwinski TA et al. | The effectiveness of ivermectin for reducing bovine gastrointestinal helminthiasis. | 1981 | Vet Med Small Anim Clin | pmid:6911919 |
| Campbell WC | An introduction to the avermectins. | 1981 | N Z Vet J | pmid:7038568 |
| Graham D et al. | Avermectin B1a inhibits the binding of strychnine to the glycine receptor of rat spinal cord. | 1982 | Neurosci. Lett. | pmid:6283439 |
| Campbell WC | Efficacy of the avermectins against filarial parasites: a short review. | 1982 | Vet. Res. Commun. | pmid:7051527 |
| Lofgren CS and Williams DF | Avermectin B1a: highly potent inhibitor of reproduction by queens of the red imported fire ant (Hymenoptera: Formicidae). | 1982 | J. Econ. Entomol. | pmid:7175003 |
| Williams M and Risley EA | Interaction of avermectins with [3H]beta-carboline-3-carboxylate ethyl ester and [3H]diazepam binding sites in rat brain cortical membranes. | 1982 | Eur. J. Pharmacol. | pmid:6277673 |
| Miwa GT et al. | The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. | 1982 May-Jun | Drug Metab. Dispos. | pmid:6125361 |
| Ishii AI et al. | Studies on chemotherapy of parasitic helminths: effects of avermectin B1a on Angiostrongylus cantonensis in rats. | 1983 | Int. J. Parasitol. | pmid:6685712 |
| Pivnichny JV et al. | Direct determination of avermectins in plasma at nanogram levels by high-performance liquid chromatography. | 1983 | J Pharm Sci | pmid:6663483 |
| Terada M et al. | Angiostrongylus cantonensis: paralysis due to avermectin B1a and ivermectin. | 1984 | Exp. Parasitol. | pmid:6143682 |
| Drexler G and Sieghart W | Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor. | 1984 | Eur. J. Pharmacol. | pmid:6088254 |
| Drexler G and Sieghart W | Properties of a high affinity binding site for [3H]avermectin B1a. | 1984 | Eur. J. Pharmacol. | pmid:6329785 |
| Todd KS et al. | Anthelmintic efficacy of avermectin B1a and dihydroavermectin B1a against ovine gastrointestinal nematodes in 1977. | 1984 | Am. J. Vet. Res. | pmid:6547280 |
| Kass IS et al. | The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. | 1984 | Mol. Biochem. Parasitol. | pmid:6096713 |
| Drexler G and Sieghart W | [35S]tert.-butylbicyclophosphorothionate and avermectin bind to different sites associated with the gamma- aminobutyric acid-benzodiazepine receptor complex. | 1984 | Neurosci. Lett. | pmid:6093013 |
| Calcott PH and Fatig RO | Inhibition of chitin metabolism by avermectin in susceptible organisms. | 1984 | J. Antibiot. | pmid:6725140 |
| Calcott PH and Fatig RO | Avermectin modulation of GABA binding to membranes of rat brain, brine shrimp and a fungus, Mucor miehei. | 1984 | J. Antibiot. | pmid:6088460 |
| Pampiglione S et al. | Avermectins, MK-933 and MK-936, for mosquito control. | 1985 | Trans. R. Soc. Trop. Med. Hyg. | pmid:3832491 |
| Onishi JC and Miller TW | The lack of antifungal activity by avermectin B1a. | 1985 | J. Antibiot. | pmid:4077735 |
| Schulman MD et al. | Demethylavermectins. Biosynthesis, isolation and characterization. | 1985 | J. Antibiot. | pmid:4077729 |
| Greene J and Goldberg RB | Isolation and preliminary characterization of lytic and lysogenic phages with wide host range within the streptomycetes. | 1985 | J. Gen. Microbiol. | pmid:2999304 |
| Chalmers AE et al. | The actions of avermectin on crayfish nerve and muscle. | 1986 | Eur. J. Pharmacol. | pmid:2430816 |
| Pampiglione S et al. | [Evaluation of the biological activity of avermectin against mosquitoes]. | 1986 | Ann. Ist. Super. Sanita | pmid:2875685 |
| Schulman MD et al. | Avermectin B2 O-methyltransferase activity in "Streptomyces avermitilis" mutants that produce increased amounts of the avermectins. | 1986 | Antimicrob. Agents Chemother. | pmid:3707112 |
| Schulman MD et al. | Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors. | 1986 | J. Antibiot. | pmid:3086265 |
| Seaman JT et al. | Avermectin B1 toxicity in a herd of Murray Grey cattle. | 1987 | Aust. Vet. J. | pmid:3426470 |
| Wright DJ | Avermectins: action on target pest species. | 1987 | Biochem. Soc. Trans. | pmid:2435585 |
| Gordnier PM et al. | Chitin metabolism: not a target of avermectin/milbemycin activity in insects. | 1987 | J. Antibiot. | pmid:2951358 |
| Ikeda H et al. | Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. | 1987 | J. Bacteriol. | pmid:3680172 |
| Schulman MD et al. | "Streptomyces avermitilis" mutants defective in methylation of avermectins. | 1987 | Antimicrob. Agents Chemother. | pmid:3606074 |
| Kirkness EF and Turner AJ | The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively. | 1988 | Eur. J. Pharmacol. | pmid:2843385 |
| Wislocki PG et al. | Dermal penetration of avermectin B1a in the rhesus monkey. | 1988 | Toxicol. Appl. Pharmacol. | pmid:3388421 |
| Matsumoto K et al. | Actions of avermectins on cultured neurons. | 1988 | Gen. Pharmacol. | pmid:3044917 |
| Ikeda H et al. | Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. | 1988 | Antimicrob. Agents Chemother. | pmid:3364948 |
| De Chaneet GC et al. | Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle. | 1988 | Aust. Vet. J. | pmid:3401149 |
| Button C et al. | Avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | Aust. Vet. J. | pmid:3401165 |
| Neszmélyi A et al. | Solution conformation of the disaccharide of avermectin B1a examined by NMR spectroscopy and nuclear Overhauser enhancement restrained hard-sphere exo-anomeric effect calculation. | 1989 | J. Antibiot. | pmid:2808137 |
| Maynard MS and Maynard HD | HPLC assay for avermectin B1a and its two photoisomers using a photo diode array detector. | 1989 | Bull Environ Contam Toxicol | pmid:2804390 |
| Zufall F et al. | The insecticide avermectin b (la) activates a chloride channel in crayfish muscle membrane. | 1989 | J. Exp. Biol. | pmid:22135837 |
| Curdová E et al. | The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis. | 1989 | J. Basic Microbiol. | pmid:2614673 |
| Robertson B | Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. | 1989 | Br. J. Pharmacol. | pmid:2478243 |
| Chen TS and Inamine ES | Studies on the biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2705778 |
| Blizzard TA et al. | Brine shrimp (Artemia salina) as a convenient bioassay for avermectin analogs. | 1989 | J. Antibiot. | pmid:2759912 |
| Schaeffer JM et al. | A chemiluminescent assay for measuring avermectin binding sites. | 1989 | Anal. Biochem. | pmid:2729548 |
| Chen TS et al. | Directed biosynthesis of avermectins. | 1989 | Arch. Biochem. Biophys. | pmid:2919882 |
| Mogg TD et al. | Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. | 1990 | Aust. Vet. J. | pmid:2085293 |
| Mann J | Organic chemistry. New routes to natural products. | 1990 | Nature | pmid:2366859 |
| Schulman MD et al. | Purification and identification of dTDP-oleandrose, the precursor of the oleandrose units of the avermectins. | 1990 | J. Biol. Chem. | pmid:2211601 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Hafner EW et al. | Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity. | 1991 | J. Antibiot. | pmid:2026560 |
| Dutton CJ et al. | Novel avermectins produced by mutational biosynthesis. | 1991 | J. Antibiot. | pmid:2026561 |
| Lasota JA and Dybas RA | Avermectins, a novel class of compounds: implications for use in arthropod pest control. | 1991 | Annu. Rev. Entomol. | pmid:2006872 |
| Haber CL et al. | Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains. | 1991 | Antimicrob. Agents Chemother. | pmid:1719935 |
| Omura S et al. | Selective production of specific components of avermectins in Streptomyces avermitilis. | 1991 | J. Antibiot. | pmid:2061197 |
| Fisher MH and Mrozik H | The chemistry and pharmacology of avermectins. | 1992 | Annu. Rev. Pharmacol. Toxicol. | pmid:1605577 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |
| Rezanka T et al. | Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1526463 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
| MacNeil DJ et al. | Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. | 1992 | Gene | pmid:1612425 |
| Goudie AC et al. | Doramectin--a potent novel endectocide. | 1993 | Vet. Parasitol. | pmid:8236738 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Gill JH and Redwin JM | Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. | 1995 | Int. J. Parasitol. | pmid:8719953 |
| Shoop WL et al. | Structure and activity of avermectins and milbemycins in animal health. | 1995 | Vet. Parasitol. | pmid:7483237 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |