Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Sangster NC et al. | Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins. | 1999 | Exp. Parasitol. | pmid:10072327 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Gopal RM et al. | Resistance of field isolates of Trichostrongylus colubriformis and Ostertagia circumcincta to ivermectin. | 1999 | Int. J. Parasitol. | pmid:10404276 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Geary TG et al. | Frontiers in anthelmintic pharmacology. | 1999 | Vet. Parasitol. | pmid:10456419 |
| Sangster NC | Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? | 1999 | Vet. Parasitol. | pmid:10485365 |
| Zhang YX et al. | Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. | 1999 | Microbiology (Reading, Engl.) | pmid:10517585 |
| Smit JW et al. | Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. | 1999 | J. Clin. Invest. | pmid:10562306 |
| Le Jambre LF et al. | Inheritance of avermectin resistance in Haemonchus contortus. | 2000 | Int. J. Parasitol. | pmid:10675751 |
| Kamijima M and Casida JE | Regional modification of [(3)H]Ethynylbicycloorthobenzoate binding in mouse brain GABA(A) receptor by endosulfan, fipronil, and avermectin B(1a). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10698677 |
| Kokoz YM et al. | Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors. | 1999 | Biosci. Rep. | pmid:10841270 |
| Gianelli L et al. | Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). | 2000 | Rapid Commun. Mass Spectrom. | pmid:10918377 |
| Novotny MJ et al. | Safety of selamectin in dogs. | 2000 | Vet. Parasitol. | pmid:10940536 |
| Krautmann MJ et al. | Safety of selamectin in cats. | 2000 | Vet. Parasitol. | pmid:10940537 |
| Tsukamoto Y et al. | Avermectin chemistry and action: ester- and ether-type candidate photoaffinity probes. | 2000 | Bioorg. Med. Chem. | pmid:10968260 |
| Banks BJ et al. | Avermectins and flea control: structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals. | 2000 | Bioorg. Med. Chem. | pmid:11003146 |
| Dawson GR et al. | Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082440 |
| Hoste H et al. | A questionnaire survey on the practices adopted to control gastrointestinal nematode parasitism in dairy goat farms in France. | 2000 | Vet. Res. Commun. | pmid:11085466 |
| Young KE et al. | Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. | 2000 | J. Zoo Wildl. Med. | pmid:11237142 |
| Barnes EH et al. | Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins. | 2001 | Int. J. Parasitol. | pmid:11336754 |
| Köhler P | The biochemical basis of anthelmintic action and resistance. | 2001 | Int. J. Parasitol. | pmid:11400692 |
| Valenzuela AI et al. | Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits. | 2001 | J Chromatogr A | pmid:11403456 |
| Wohlert S et al. | Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. | 2001 | Chem. Biol. | pmid:11451669 |
| Swarnkar CP et al. | Anthelmintic resistance on an organized sheep farm in India. | 2001 | Trop Anim Health Prod | pmid:11474864 |
| Sha CK et al. | Anionic cyclization approach toward perhydrobenzofuranone: stereocontrolled synthesis of the hexahydrobenzofuran subunit of avermectin. | 2002 | J. Org. Chem. | pmid:11856026 |
| Veale PI | Resistance to macrocyclic lactones in nematodes of goats. | 2002 | Aust. Vet. J. | pmid:12074315 |
| Deger Y et al. | Short communication serum copper, zinc, and calcium concentrations in lice-infested sheep. | 2002 | Biol Trace Elem Res | pmid:12117268 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Kim SB and Goodfellow M | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508861 |
| Takahashi Y et al. | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12508884 |
| Hwang YS et al. | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | 2003 | Appl. Environ. Microbiol. | pmid:12571055 |
| Martins JR et al. | Partial strategic tick control within a herd of European breed cattle in the state of Rio Grande do Sul, southern Brazil. | 2002 | Exp. Appl. Acarol. | pmid:12593589 |
| Stutzman-Engwall K et al. | Engineering the aveC gene to enhance the ratio of doramectin to its CHC-B2 analogue produced in Streptomyces avermitilis. | 2003 | Biotechnol. Bioeng. | pmid:12599263 |
| Arena JP et al. | Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin. | 1992 | Brain Res. Mol. Brain Res. | pmid:1279355 |
| Sun Y et al. | Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. | 2003 | Arch. Microbiol. | pmid:12811466 |
| Lamb DC et al. | Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). | 2003 | Biochem. Biophys. Res. Commun. | pmid:12893267 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Yates DM et al. | The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans. | 2003 | Int. J. Parasitol. | pmid:13678634 |
| Stong JD et al. | Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products. | 1992 | J Pharm Sci | pmid:1432608 |
| Blackhall WJ et al. | Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | 2003 | Mol. Biochem. Parasitol. | pmid:14511812 |
| Nagai K et al. | Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592480 |
| Yoon YJ et al. | Avermectin: biochemical and molecular basis of its biosynthesis and regulation. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14689246 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Chen J et al. | Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis. | 2004 | Biotechnol. Lett. | pmid:15000476 |
| Liu J et al. | Genomic organization of an avermectin receptor subunit from Haemonchus contortus and expression of its putative promoter region in Caenorhabditis elegans. | 2004 | Mol. Biochem. Parasitol. | pmid:15003846 |
| Korystov YN et al. | Avermectins inhibit multidrug resistance of tumor cells. | 2004 | Eur. J. Pharmacol. | pmid:15189764 |
| Nagai K et al. | Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261257 |
| Rezanka T et al. | Influence of inhibitors of lipid biosynthesis on the production of avermectins in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1526463 |