Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meinke PT et al. | Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934486 |
| Delany NS et al. | Cloning and localisation of an avermectin receptor-related subunit from Haemonchus contortus. | 1998 | Mol. Biochem. Parasitol. | pmid:9879896 |
| Lankas GR et al. | Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. | 1998 Jul-Aug | Reprod. Toxicol. | pmid:9717696 |
| Gill JH and Lacey E | Avermectin/milbemycin resistance in trichostrongyloid nematodes. | 1998 | Int. J. Parasitol. | pmid:9673866 |
| Lonneux JF et al. | The relationship between parasite counts, lesions, antibody titres and daily weight gains in Psoroptes ovis infested cattle. | 1998 | Vet. Parasitol. | pmid:9653998 |
| Gill JH et al. | Evidence of multiple mechanisms of avermectin resistance in haemonchus contortus--comparison of selection protocols. | 1998 | Int. J. Parasitol. | pmid:9650059 |
| Ikeda H et al. | Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. | 1998 | Gene | pmid:9469930 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Vassilatis DK et al. | Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization. | 1997 | J. Biol. Chem. | pmid:9407104 |
| Barnes TM and Hekimi S | The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. | 1997 | J. Neurochem. | pmid:9375655 |
| Lonneux JF et al. | Antibody response after treatment in cattle infected with Psoroptes ovis. | 1997 Jul-Aug | Res. Vet. Sci. | pmid:9368957 |
| Laughton DL et al. | Reporter gene constructs suggest that the Caenorhabditis elegans avermectin receptor beta-subunit is expressed solely in the pharynx. | 1997 | J. Exp. Biol. | pmid:9192499 |
| Pomes A et al. | Target size analysis of an avermectin binding site from Drosophila melanogaster. | 1997 | Biochim. Biophys. Acta | pmid:9187243 |
| Huang J and Casida JE | Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103505 |
| Shoop WL et al. | Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024867 |
| Shoop WL et al. | Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. | 1996 | Int. J. Parasitol. | pmid:9024866 |
| McKellar QA and Benchaoui HA | Avermectins and milbemycins. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8905567 |
| Venkatachalam MA et al. | Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. | 1996 | Kidney Int. | pmid:8821829 |
| Herd R | Ecotoxicity of the avermectins: a reply to Forbes. | 1996 | Int. J. Parasitol. | pmid:8818740 |
| Gill JH and Redwin JM | Cryopreservation of the first-stage larvae of trichostrongylid nematode parasites. | 1995 | Int. J. Parasitol. | pmid:8719953 |
| Cully DF et al. | Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. | 1996 | J. Biol. Chem. | pmid:8702744 |
| Nari A et al. | The prevalence of anthelmintic resistance in nematode parasites of sheep in southern Latin America: Uruguay. | 1996 | Vet. Parasitol. | pmid:8686167 |
| MacNeil T et al. | Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement. | 1993 | J. Bacteriol. | pmid:8478321 |
| Ikeda H et al. | Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. | 1993 | J. Bacteriol. | pmid:8384619 |
| Sams R | Chemical assay of avermectins by high performance liquid chromatography with fluorescence detection. | 1993 | Vet. Parasitol. | pmid:8346649 |
| Herd R et al. | Research recommendations. | 1993 | Vet. Parasitol. | pmid:8346647 |
| Strong L | Overview: the impact of avermectins on pastureland ecology. | 1993 | Vet. Parasitol. | pmid:8346644 |
| Waller PJ et al. | Regional and temporal use of avermectins for ruminants in Australia. | 1993 | Vet. Parasitol. | pmid:8346642 |
| McCracken DI | The potential for avermectins to affect wildlife. | 1993 | Vet. Parasitol. | pmid:8346640 |
| King KL | The potential for avermectins to affect the nutrient economy of grazed pastures. | 1993 | Vet. Parasitol. | pmid:8346639 |
| Ridsdill-Smith TJ | Effects of avermectin residues in cattle dung on dung beetle (Coleoptera: Scarabaeidae) reproduction and survival. | 1993 | Vet. Parasitol. | pmid:8346627 |
| Special issue: Environmental impact of avermectin usage in livestock. | 1993 | Vet. Parasitol. | pmid:8346625 | |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''. | 1993 | Antimicrob. Agents Chemother. | pmid:8239577 |
| Goudie AC et al. | Doramectin--a potent novel endectocide. | 1993 | Vet. Parasitol. | pmid:8236738 |
| Schulman M et al. | Microbial conversion of avermectins by Saccharopolyspora erythraea: hydroxylation at C-27. | 1994 | J. Antibiot. | pmid:8175491 |
| Naito S et al. | Milbemycin derivatives: modification at the C-5 position. | 1994 | J. Antibiot. | pmid:8150720 |
| Rohrer SP et al. | Immunoaffinity purification of avermectin-binding proteins from the free-living nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster. | 1994 | Biochem. J. | pmid:8092985 |
| Evans M et al. | Characterization of a Streptomyces-lividans-type site-specific DNA modification system in the avermectin-producer Streptomyces avermitilis permits investigation of two novel giant linear plasmids, pSA1 and pSA2. | 1994 | Microbiology (Reading, Engl.) | pmid:8081502 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| MacNeil DJ et al. | Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8010663 |
| Cully DF et al. | Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. | 1994 | Nature | pmid:7935817 |
| Ikeda H et al. | Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868399 |
| Pang CH et al. | Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868398 |
| Pang CH et al. | Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7868391 |
| Clark JM et al. | Resistance to avermectins: extent, mechanisms, and management implications. | 1995 | Annu. Rev. Entomol. | pmid:7810984 |
| Denoya CD et al. | A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins. | 1995 | J. Bacteriol. | pmid:7768860 |
| Le Jambre LF et al. | Characterisation of an avermectin resistant strain of Australian Haemonchus contortus. | 1995 | Int. J. Parasitol. | pmid:7657454 |
| Ikeda H and Omura S | Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. | 1995 | J. Antibiot. | pmid:7649850 |
| Gill JH et al. | Avermectin inhibition of larval development in Haemonchus contortus--effects of ivermectin resistance. | 1995 | Int. J. Parasitol. | pmid:7635622 |
| Ikeda H et al. | Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. | 1995 | J. Antibiot. | pmid:7622445 |