Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Zou CS et al. | Purification, characterization, and sensitivity to pesticides of carboxylesterase from Dendrolimus superans (Lepidoptera: Lasiocampidae). | 2014 | J. Insect Sci. | pmid:25525114 |
| Liu C et al. | Effects of avermectin on heat shock proteins expression and histopathology in spleen tissues of pigeon. | 2014 | Chem. Biol. Interact. | pmid:25446859 |
| Guo H et al. | Reversal of meticillin resistance in Staphylococcus aureus by the anthelmintic avermectin. | 2014 | Int. J. Antimicrob. Agents | pmid:25123810 |
| Thuan NH et al. | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25104027 |
| Shen W et al. | [Study on the inclusion compound of avermectin by infrared spectroscopy]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:25095407 |
| Cao Y et al. | Global DNA hypomethylation: a potential mechanism in King pigeon nerve tissue damage induced by avermectin. | 2014 | Chem. Biol. Interact. | pmid:24858076 |
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Sun P et al. | Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. | 2014 | Chembiochem | pmid:24573905 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Liu C et al. | Effects of avermectin on immune function and oxidative stress in the pigeon spleen. | 2014 | Chem. Biol. Interact. | pmid:24412236 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |
| McMahon C et al. | Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. | 2013 | Vet. Parasitol. | pmid:23398988 |
| Park JH et al. | Application of hollow-fiber-assisted liquid-phase microextraction to identify avermectins in stream water using MS/MS. | 2013 | J Sep Sci | pmid:23504817 |
| Sun P et al. | Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. | 2013 | J. Am. Chem. Soc. | pmid:23294008 |
| Yin P et al. | Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production. | 2013 | J Proteomics | pmid:23201115 |
| Park JH et al. | Development of an extraction method for the determination of avermectins in soil using supercritical CO2 modified with ethanol and liquid chromatography-tandem mass spectrometry. | 2013 | J Sep Sci | pmid:23109286 |
| Lim LE et al. | Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165468 |
| Yan Y et al. | Utilization of environmental waste cyanobacteria as a pesticide carrier: studies on controlled release and photostability of avermectin. | 2013 | Colloids Surf B Biointerfaces | pmid:23006573 |
| Zhao X et al. | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | 2013 | World J. Microbiol. Biotechnol. | pmid:23579768 |
| Luo L et al. | Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway. | 2013 | Chem. Biol. Interact. | pmid:23523950 |
| Guo J et al. | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | 2013 | PLoS ONE | pmid:23967193 |
| Liu Y et al. | Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. | 2013 | J. Bacteriol. | pmid:23893108 |
| Li M et al. | Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin. | 2013 | Ecotoxicology | pmid:23943211 |
| Chen LJ et al. | Avermectin induced inflammation damage in king pigeon brain. | 2013 | Chemosphere | pmid:24134892 |
| Zhu WJ et al. | Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24138898 |
| Doan HT et al. | The efficacy of avermectins (ivermectin, doramectin and abamectin) as treatments for infestation with the tick Haemaphysalis longicornis on rabbits in Korea. | 2013 | Vet. Parasitol. | pmid:24140165 |
| Komatsu M et al. | Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. | 2013 | ACS Synth Biol | pmid:23654282 |
| Campbell WC | History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. | 2012 | Curr Pharm Biotechnol | pmid:22039784 |
| Danaher M et al. | Recent developments in the analysis of avermectin and milbemycin residues in food safety and the environment. | 2012 | Curr Pharm Biotechnol | pmid:22039790 |
| Horsberg TE | Avermectin use in aquaculture. | 2012 | Curr Pharm Biotechnol | pmid:22039799 |
| Jiang X et al. | Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21842154 |
| Lopes RP et al. | Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. | 2012 | Talanta | pmid:22284481 |
| Erban T et al. | The efficacy of four avermectins on the synanthropic mite Lepidoglyphus destructor under laboratory conditions. | 2012 | Exp. Appl. Acarol. | pmid:22527833 |
| Tao Y et al. | Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22542398 |
| Molento MB et al. | Resistance to avermectin/milbemycin anthelmintics in equine cyathostomins - current situation. | 2012 | Vet. Parasitol. | pmid:22047763 |
| Wang C et al. | A monoclonal antibody-based ELISA for multiresidue determination of avermectins in milk. | 2012 | Molecules | pmid:22706371 |
| Yu Z et al. | Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. | 2012 | Mol. Microbiol. | pmid:22676800 |
| Gao Y et al. | Insecticide-mediated apparent displacement between two invasive species of leafminer fly. | 2012 | PLoS ONE | pmid:22662122 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Zhang X et al. | Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22350115 |
| Merola VM and Eubig PA | Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | 2012 | Vet. Clin. North Am. Small Anim. Pract. | pmid:22381182 |
| Awasthi A et al. | An overview on chemical derivatization and stability aspects of selected avermectin derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22863694 |
| Alves SN et al. | [Susceptibility of Culex quinquefasciatus larvae to different insecticides]. | 2011 Jul-Aug | Rev. Soc. Bras. Med. Trop. | pmid:21860896 |
| Rezanka T et al. | Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces. | 2011 | Environ. Microbiol. | pmid:21450004 |
| Sargison ND et al. | Effects of age and immune suppression of sheep on fecundity, hatching and larval feeding of different strains of Haemonchus contortus. | 2011 | Vet. J. | pmid:20822936 |
| Guan HN et al. | Novel photodegradable insecticide W/TiO(2)/Avermectin nanocomposites obtained by polyelectrolytes assembly. | 2011 | Colloids Surf B Biointerfaces | pmid:21131183 |
| Sherman JG | Understanding the impact of P-glycoprotein mutation on canine health. | 2011 | Vet. J. | pmid:21106417 |
| Miyamoto KT et al. | The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. | 2011 | Microbiology (Reading, Engl.) | pmid:21622528 |
| Qiu J et al. | Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21713508 |
| Jiang L et al. | Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. | 2011 | Biotechnol. Lett. | pmid:21691838 |
| Wang XX et al. | Yeast screening from avermectins wastewater and investigation on the ability of its fermentation. | 2011 | Bioprocess Biosyst Eng | pmid:21698347 |
| Wang JB et al. | Production of doramectin by rational engineering of the avermectin biosynthetic pathway. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21514826 |
| Wang F et al. | Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21598143 |
| Yamamuro D et al. | Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans. | 2011 | Biol. Pharm. Bull. | pmid:21963505 |
| Jin T et al. | Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. | 2011 | Pest Manag. Sci. | pmid:21308963 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Kitani S et al. | Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21930904 |
| Tom LA and Foster N | Development of a molecularly imprinted polymer for the analysis of avermectin. | 2010 | Anal. Chim. Acta | pmid:20969995 |
| Wolstenholme AJ | Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep. | 2010 | Invert. Neurosci. | pmid:20953673 |
| Webb L et al. | Field-scale dispersal of Aphodius dung beetles (Coleoptera: Scarabaeidae) in response to avermectin treatments on pastured cattle. | 2010 | Bull. Entomol. Res. | pmid:19586576 |
| Li L et al. | Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20352288 |
| Molinari G et al. | New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. | 2010 | Cytogenet. Genome Res. | pmid:20389039 |
| Wang LY et al. | Novel mutation breeding method for Streptomyces avermitilis using an atmospheric pressure glow discharge plasma. | 2010 | J. Appl. Microbiol. | pmid:19735332 |
| Guo J et al. | The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. | 2010 | Mol. Genet. Genomics | pmid:20012992 |
| Sperry J et al. | Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. | 2010 | Org. Biomol. Chem. | pmid:20024126 |
| Gao H et al. | Identification of avermectin-high-producing strains by high-throughput screening methods. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19957083 |
| Alves SN et al. | Alterations in the fat body and midgut of Culex quinquefasciatus larvae following exposure to different insecticides. | 2010 | Micron | pmid:20452779 |
| Gao H et al. | Assessing the potential of an induced-mutation strategy for avermectin overproducers. | 2010 | Appl. Environ. Microbiol. | pmid:20453119 |
| Hassan MU et al. | Bovine hypodermosis--a global aspect. | 2010 | Trop Anim Health Prod | pmid:20607401 |
| Orpin P | Potential avermectin resistance in a cattle herd. | 2010 | Vet. Rec. | pmid:20622213 |
| Li M et al. | Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. | 2010 | Bioresour. Technol. | pmid:20655739 |
| Whelan M et al. | Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching. | 2010 | J Chromatogr A | pmid:20564781 |
| Sargison ND et al. | Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock. | 2010 | Vet. Rec. | pmid:20511651 |
| Zhuo Y et al. | Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534557 |
| Pitterna T et al. | New ventures in the chemistry of avermectins. | 2009 | Bioorg. Med. Chem. | pmid:19168364 |
| Duong CT et al. | Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. | 2009 | J. Microbiol. Biotechnol. | pmid:19307761 |
| Kitani S et al. | Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19148632 |
| Wang H et al. | Rapid method for multi-residue determination of avermectins in bovine liver using high-performance liquid chromatography with fluorescence detection. | 2009 | Bull Environ Contam Toxicol | pmid:19159053 |
| Thompson TS et al. | Large volume injection for the direct analysis of ionophores and avermectins in surface water by liquid chromatography-electrospray ionization tandem mass spectrometry. | 2009 | Anal. Chim. Acta | pmid:19110126 |
| dos Santos AR et al. | Ivermectin-derived leishmanicidal compounds. | 2009 | Bioorg. Med. Chem. | pmid:19114308 |
| Ci X et al. | Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. | 2009 | Fundam Clin Pharmacol | pmid:19453757 |
| Shiwen X et al. | Preparation and characterization of monoclonal antibodies against avermectin. | 2009 | Hybridoma (Larchmt) | pmid:19519244 |
| Sung YF et al. | Avermectin intoxication with coma, myoclonus, and polyneuropathy. | 2009 | Clin Toxicol (Phila) | pmid:19640241 |
| Gao H et al. | Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology. | 2009 | Bioresour. Technol. | pmid:19356927 |
| Inoue K et al. | Simultaneous determination of avermectins in bovine tissues by LC-MS/MS. | 2009 | J Sep Sci | pmid:19877150 |
| Zhao X et al. | Construction of a doramectin producer mutant from an avermectin-overproducing industrial strain of Streptomyces avermitilis. | 2009 | Can. J. Microbiol. | pmid:20029527 |
| Krogh KA et al. | Development of an analytical method to determine avermectins in water, sediments and soils using liquid chromatography-tandem mass spectrometry. | 2008 | J Chromatogr A | pmid:18929364 |
| Li M et al. | Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18824353 |
| Dong JY et al. | Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029. | 2008 | J. Nat. Prod. | pmid:18479163 |
| Kessabi FM et al. | Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. | 2008 | Org. Lett. | pmid:18461948 |
| Chen L et al. | Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18560830 |