Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Silva GRD et al. | Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. | 2017 | Talanta | pmid:28551144 |
| Brownjohn PW et al. | Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. | 2017 | Stem Cell Reports | pmid:28285880 |
| Marsden AF et al. | Engineering broader specificity into an antibiotic-producing polyketide synthase. | 1998 | Science | pmid:9422686 |
| Jin L et al. | Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease. | 2015 | Sci Rep | pmid:26620317 |
| Liu X et al. | Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. | 2017 | Sci Rep | pmid:28303934 |
| Zhao X et al. | Pesticide-mediated interspecific competition between local and invasive thrips pests. | 2017 | Sci Rep | pmid:28084404 |
| Guo J et al. | Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). | 2016 | Sci Rep | pmid:27181521 |
| Sun D et al. | SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development. | 2016 | Sci Rep | pmid:27841302 |
| Chen J et al. | Different fates of avermectin and artemisinin in China. | 2016 | Sci China Life Sci | pmid:27132020 |
| Strabel D et al. | [The use of avermectins in two goats with demodicosis]. | 2003 | Schweiz. Arch. Tierheilkd. | pmid:14725185 |
| Alves SN et al. | [Susceptibility of Culex quinquefasciatus larvae to different insecticides]. | 2011 Jul-Aug | Rev. Soc. Bras. Med. Trop. | pmid:21860896 |
| Lonneux JF et al. | Antibody response after treatment in cattle infected with Psoroptes ovis. | 1997 Jul-Aug | Res. Vet. Sci. | pmid:9368957 |
| Lankas GR et al. | Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. | 1998 Jul-Aug | Reprod. Toxicol. | pmid:9717696 |
| Gianelli L et al. | Mass spectrometry of avermectins: structural determination of two new derivatives of Ivermectin B(1a). | 2000 | Rapid Commun. Mass Spectrom. | pmid:10918377 |
| Brewer BN et al. | Determination of abamectin in soil samples using high-performance liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15282767 |
| Turnipseed SB et al. | No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16541409 |
| Turnipseed SB et al. | Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry. | 1999 | Rapid Commun. Mass Spectrom. | pmid:10204245 |
| Ikeda H et al. | Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449723 |
| Zhuo Y et al. | Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20534557 |
| Kitani S et al. | Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21930904 |
| Rohrer SP et al. | Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1315055 |
| Cornejo I et al. | Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. | 2014 | PLoS Pathog. | pmid:25255455 |
| Guo J et al. | Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. | 2014 | PLoS ONE | pmid:24915523 |
| Li M et al. | Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01. | 2014 | PLoS ONE | pmid:24905717 |
| Huang WK et al. | Efficacy evaluation of fungus Syncephalastrum racemosum and nematicide avermectin against the root-knot nematode Meloidogyne incognita on cucumber. | 2014 | PLoS ONE | pmid:24586982 |
| Cui B et al. | Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques. | 2018 | PLoS ONE | pmid:29360866 |
| Liu M et al. | Magnetic field is the dominant factor to induce the response of Streptomyces avermitilis in altered gravity simulated by diamagnetic levitation. | 2011 | PLoS ONE | pmid:22039402 |
| Gao Y et al. | Insecticide-mediated apparent displacement between two invasive species of leafminer fly. | 2012 | PLoS ONE | pmid:22662122 |
| Guo J et al. | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | 2013 | PLoS ONE | pmid:23967193 |
| Omansen TF et al. | In-vitro activity of avermectins against Mycobacterium ulcerans. | 2015 | PLoS Negl Trop Dis | pmid:25742173 |
| Efferth T et al. | Nobel Prize for artemisinin brings phytotherapy into the spotlight. | 2015 | Phytomedicine | pmid:26563851 |
| Roos MH et al. | Molecular aspects of drug resistance in parasitic helminths. | 1993 | Pharmacol. Ther. | pmid:8022863 |
| Liu C et al. | Avermectin induced global DNA hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon. | 2017 | Pestic Biochem Physiol | pmid:28043331 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Mermans C et al. | A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones. | 2017 | Pest Manag. Sci. | pmid:28736919 |
| Jin T et al. | Insecticide resistance of the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), in mainland China. | 2011 | Pest Manag. Sci. | pmid:21308963 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Shi ZH et al. | Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). | 2004 | Pest Manag. Sci. | pmid:15578602 |
| Wen LX et al. | Controlled release of avermectin from porous hollow silica nanoparticles. | 2005 | Pest Manag. Sci. | pmid:15714463 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Byrne FJ et al. | Evaluation of neonicotinoid, organophosphate and avermectin trunk injections for the management of avocado thrips in California avocado groves. | 2012 | Pest Manag. Sci. | pmid:22396314 |
| Wolstenholme AJ and Rogers AT | Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | 2005 | Parasitology | pmid:16569295 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Sangster NC and Gill J | Pharmacology of anthelmintic resistance. | 1999 | Parasitol. Today (Regul. Ed.) | pmid:10322335 |
| Rehbein S et al. | Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle. | 2002 | Parasitol. Res. | pmid:12444456 |
| Godoy P et al. | Characterisation of P-glycoprotein-9.1 in Haemonchus contortus. | 2016 | Parasit Vectors | pmid:26822677 |
| Kessabi FM et al. | Rearrangement of a cyclohexyl radical to a cyclopentylmethyl radical on the avermectin skeleton. | 2008 | Org. Lett. | pmid:18461948 |
| Brady PB et al. | Stereodivergent approach to the avermectins based on "super silyl" directed aldol reactions. | 2014 | Org. Lett. | pmid:25025525 |
| Sperry J et al. | Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction. | 2010 | Org. Biomol. Chem. | pmid:20024126 |