Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brewer BN et al. | Determination of abamectin in soil samples using high-performance liquid chromatography with tandem mass spectrometry. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15282767 |
| Drinyaev VA et al. | Antitumor effect of avermectins. | 2004 | Eur. J. Pharmacol. | pmid:15464058 |
| MacNeil DJ et al. | Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. | 1992 | Gene | pmid:1547955 |
| Shi ZH et al. | Evaluation of selective toxicity of five pesticides against Plutella xylostella (Lep: Plutellidae) and their side-effects against Cotesia plutellae (Hym: Braconidae) and Oomyzus sokolowskii (Hym: Eulophidae). | 2004 | Pest Manag. Sci. | pmid:15578602 |
| Wen LX et al. | Controlled release of avermectin from porous hollow silica nanoparticles. | 2005 | Pest Manag. Sci. | pmid:15714463 |
| Shen J et al. | Bioconcentration and elimination of avermectin B1 in sturgeon. | 2005 | Environ. Toxicol. Chem. | pmid:15720000 |
| Wei L et al. | Synthesis of new, potent avermectin-like insecticidal agents. | 2005 | Carbohydr. Res. | pmid:15922315 |
| Sun Y et al. | Bioaccumulation and elimination of avermectin B1a in the earthworms (Eisenia fetida). | 2005 | Chemosphere | pmid:15963808 |
| Kuzmina TA et al. | Analysis of the strongylid nematodes (Nematoda: Strongylidae) community after deworming of brood horses in Ukraine. | 2005 | Vet. Parasitol. | pmid:15979240 |
| Yong JH and Byeon WH | Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. | 2005 | J. Microbiol. | pmid:15995647 |
| Fisher MH and Mrozik H | The chemistry and pharmacology of avermectins. | 1992 | Annu. Rev. Pharmacol. Toxicol. | pmid:1605577 |
| Bowen JM and Vitayavirasak B | Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds. | 2005 | Vet. Parasitol. | pmid:16076531 |
| Novák J et al. | Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. | 1992 | FEMS Microbiol. Lett. | pmid:1612418 |
| MacNeil DJ et al. | Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. | 1992 | Gene | pmid:1612425 |
| Erzen NK et al. | Degradation of abamectin and doramectin on sheep grazed pasture. | 2005 | Ecotoxicology | pmid:16215697 |
| Jungmann V et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. | 2005 | Appl. Environ. Microbiol. | pmid:16269732 |
| Molnár I et al. | Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. | 2005 | Appl. Environ. Microbiol. | pmid:16269733 |
| Li ZZ et al. | Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. | 2006 | J Control Release | pmid:16388871 |
| Walsh CT | Natural insights for chemical biologists. | 2005 | Nat. Chem. Biol. | pmid:16408011 |
| Sun Y et al. | [Effects of avermectin B1a on soil microorganism and earthworm (Eisenia fetida)]. | 2005 | Ying Yong Sheng Tai Xue Bao | pmid:16471355 |
| Turnipseed SB et al. | No-discharge atmospheric pressure chemical ionization: evaluation and application to the analysis of animal drug residues in complex matrices. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16541409 |
| Beasley CA et al. | Identification of impurities in ivermectin bulk material by mass spectrometry and NMR. | 2006 | J Pharm Biomed Anal | pmid:16554137 |
| Wolstenholme AJ and Rogers AT | Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. | 2005 | Parasitology | pmid:16569295 |
| Payne GT and Soderlund DM | Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. | 1991 | J. Biochem. Toxicol. | pmid:1663556 |
| Zhang X et al. | Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16708195 |
| Oremus G et al. | Effects of mid-season avermectin treatments on pyrethroid resistance in horn fly (Diptera: Muscidae) populations at three locations in Louisiana. | 2006 | Vet. Parasitol. | pmid:16769175 |
| Wei X et al. | Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis. | 2006 | Biotechnol. Lett. | pmid:16786277 |
| Rajkarnikar A et al. | Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272. | 2006 | Curr. Microbiol. | pmid:16874544 |
| Shi W et al. | Determination of multiresidue of avermectins in bovine liver by an indirect competitive ELISA. | 2006 | J. Agric. Food Chem. | pmid:16910699 |
| Learmount J et al. | A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms. | 2006 | Vet. Parasitol. | pmid:16930844 |
| Danaher M et al. | Review of methodology for the determination of macrocyclic lactone residues in biological matrices. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16950666 |
| Artho R et al. | Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. | 2007 | Vet. Parasitol. | pmid:17088023 |
| Arena JP et al. | Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. | 1991 | Mol. Pharmacol. | pmid:1716730 |
| Li ZZ et al. | Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin. | 2007 | Pest Manag. Sci. | pmid:17177171 |
| Zhang C et al. | The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility. | 2006 | J. Am. Chem. Soc. | pmid:17177349 |
| Sheehan LS et al. | Engineering of the spinosyn PKS: directing starter unit incorporation. | 2006 | J. Nat. Prod. | pmid:17190446 |
| Haber CL et al. | Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains. | 1991 | Antimicrob. Agents Chemother. | pmid:1719935 |
| Tribble ND et al. | Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). | 2007 | J. Vet. Pharmacol. Ther. | pmid:17348903 |
| Macdonald N and Gledhill A | Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. | 2007 | Arch. Toxicol. | pmid:17354009 |
| Berendsen BJ et al. | The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. | 2007 | Anal. Chim. Acta | pmid:17386656 |
| Webb L et al. | Effects of avermectin residues in cattle dung on yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae) populations in grazed pastures. | 2007 | Bull. Entomol. Res. | pmid:17411477 |
| Li ZZ et al. | Adsorption of avermectin on porous hollow silica nanoparticles by supercritical technology. | 2007 | J Nanosci Nanotechnol | pmid:17450791 |
| Trefzer A et al. | Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. | 2007 | Appl. Environ. Microbiol. | pmid:17483257 |
| Hernando MD et al. | Fast separation liquid chromatography-tandem mass spectrometry for the confirmation and quantitative analysis of avermectin residues in food. | 2007 | J Chromatogr A | pmid:17524410 |
| Lin YW et al. | Insecticide susceptibility of surviving Cotesia plutellae (Hym: Braconidae) and Diaeretiella rapae (M'Intosh) (Hym: Aphidiidae) as affected by sublethal insecticide dosages on host insects. | 2007 | Pest Manag. Sci. | pmid:17533655 |
| Brayden DJ and Griffin J | Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers. | 2008 | Vet. Res. Commun. | pmid:17578674 |
| Gill JH et al. | Detection of resistance to ivermectin in Haemonchus contortus. | 1991 | Int. J. Parasitol. | pmid:1774112 |
| Im JH et al. | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | 2007 | J. Microbiol. Biotechnol. | pmid:18050961 |
| Rajkarnikar A et al. | Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. | 2007 | J. Microbiol. Biotechnol. | pmid:18062239 |
| Ayers S et al. | Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. | 2008 | J. Antibiot. | pmid:18408323 |